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 Health  Vol.8 No.15 , December 2016
Association of Obesity in Children with Pancreatitis in a Predominantly Hispanic Population at the US-Mexican Border: A Single Center Outpatient Study
Abstract: Importance: The incidence of pancreatitis has been increasing over the last decade. Limited data are available for pancreatitis in the Hispanic population. The clinical profile of pancreatitis and its association with obesity in a Mexican American population has not been well studied. Objective: To describe prevalence, the characteristics of pancreatitis cases, and determine its association with obesity. Design and Setting: Retrospective review of children from February 2012 to February 2015, at the Texas Tech University Health Sciences Center of El Paso (TTUHSC-El Paso) outpatient center. Case/non-case study was used to determine the association of overweight and obesity with pancreatitis. Participants: Children ages 2 - 18 years, only the newly diagnosed pancreatitis cases irrespective of its type excluding patients with traumatic and repeat visit for pancreatitis. Main Outcome and Measures: Pancreatitis and obesity. Results: The prevalence of pancreatitis was estimated as 20 cases in 21,444 patients seen in the outpatient clinic. In multivariable analysis, only obesity and ethnicity were significantly associated with pancreatitis. Obesity was found to be more than 7-fold likely with pancreatitis as compared to non-cases. Overweight was found to be more than 6-fold likely with pancreatitis as compared with non-cases. Our study demonstrates an association between obesity and pancreatitis in the study population. Conclusions and Relevance: Appropriate intervention for managing obesity may reduce the prevalence of pancreatitis and associated co-morbidities. A larger prospective study should be done to determine underlying causes of association between obesity and pancreatitis.
Cite this paper: Pathak, I. , Malbas, D. , Rai, P. and Dwivedi, A. (2016) Association of Obesity in Children with Pancreatitis in a Predominantly Hispanic Population at the US-Mexican Border: A Single Center Outpatient Study. Health, 8, 1820-1829. doi: 10.4236/health.2016.815174.
References

[1]   Ma, M.H., Bai, H.X., Park, A.J., et al. (2012) Risk Factors Associated with Biliary Pancreatitis in Children. Journal of Pediatric Gastroenterology and Nutrition, 54, 651-656.
https://doi.org/10.1097/MPG.0b013e31823a897d

[2]   Stimac, D. and Franjic, N. (2011) Obesity and Acute Pancreatitis. Acute Pancreatitis: InTech Open.

[3]   Morinville, V.D., Barmada, M.M. and Lowe, M.E. (2010) Increasing Incidence of Acute Pancreatitis at an American Pediatric Tertiary Care Center: Is Greater Awareness among Physicians Responsible? Pancreas, 39, 5-8.
https://doi.org/10.1097/MPA.0b013e3181baac47

[4]   Nydegger, A., Heine, R.G., Ranuh, R., Gegati-Levy, R., Crameri, J. and Oliver, M.R. (2007) Changing Incidence of Acute Pancreatitis: 10-Year Experience at the Royal Children's Hospital, Melbourne. Journal of Gastroenterology and Hepatology, 22, 1313-1316.
https://doi.org/10.1111/j.1440-1746.2007.04936.x

[5]   Minen, F., De Cunto, A., Martelossi, S. and Ventura, A. (2012) Acute and Recurrent Pancreatitis in Children: Exploring Etiological Factors. Scandinavian Journal of Gastroenterology, 47, 1501-1504.
https://doi.org/10.3109/00365521.2012.729084

[6]   Kwak, B.O., Lee, M.J., Park, H.W., Kim, K.S. and Chung, S. (2014) A Case of Recurrent Acute Pancreatitis in an Obese Child. Nutrition, 30, 1213-1216.
https://doi.org/10.1016/j.nut.2014.04.002

[7]   Frossard, J.L., Lescuyer, P. and Pastor, C.M. (2009) Experimental Evidence of Obesity as a Risk Factor for Severe Acute Pancreatitis. World Journal of Gastroenterology, 15, 5260-5265.
https://doi.org/10.3748/wjg.15.5260

[8]   Abu-El-Haija, M., Lin, T.K. and Palermo, J. (2014) Update to the Management of Pediatric Acute Pancreatitis: Highlighting Areas in Need of Research. Journal of Pediatric Gastroenterology and Nutrition, 58, 689-693.
https://doi.org/10.1097/mpg.0000000000000360

[9]   Ogden, C.L., Carroll, M.D., Kit, B.K. and Flegal, K.M. (2014) Prevalence of Childhood and Adult Obesity in the United States, 2011-2012. JAMA, 311, 806-814.
https://doi.org/10.1001/jama.2014.732

[10]   Cali, A.M. and Caprio, S. (2008) Obesity in Children and Adolescents. The Journal of Clinical Endocrinology & Metabolism, 93, S31-S36.
https://doi.org/10.1210/jc.2008-1363

[11]   Pohl, J.F. and Uc, A. (2015) Paediatric Pancreatitis. Current Opinion in Gastroenterology, 31, 380-386.
https://doi.org/10.1097/MOG.0000000000000197

[12]   Nguyen, D.M. and El-Serag, H.B. (2010) The Epidemiology of Obesity. Gastroenterology Clinics of North America, 39, 1-7.
https://doi.org/10.1016/j.gtc.2009.12.014

[13]   Suzuki, M., Sai, J.K. and Shimizu, T. (2014) Acute pancreatitis in children and adolescents. World Journal of Gastrointestinal Pathophysiology, 5, 416-426.
https://doi.org/10.4291/wjgp.v5.i4.416

[14]   Vasilescu, A., Cuffari, C., Santo Domingo, L. and Scheimann, A.O. (2015) Predictors of Severity in Childhood Pancreatitis: Correlation with Nutritional Status and Racial Demographics. Pancreas, 44, 401-403.

 
 
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