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 Health  Vol.8 No.15 , December 2016
Relationship between Physical Activity Level, Hepatic Steatosis Presence, Metabolic Syndrome and the Risk of Developing Type 2 Diabetes in Men
Abstract: Cardiovascular disease, cancer, respiratory and metabolic disease represent 63% of all deaths worldwide and are considered the major causes of morbidity and mortality. Physical inactivity is considered a case of public health, and other behavioral and metabolic risk factors, according to WHO (2011), such as smoking, increased blood pressure, increased blood glucose, hypercholesterolemia, overweight and obesity. The Nonalcoholic Fatty Liver Disease (NAFLD) is the most prevalent liver disease in adults, and can progress and be characterized as hepatic steatosis (HS) which is derived from the accumulation of lipids in hepatocytes, and histopathologic condition is more than 5% of the weight of liver. So, the purpose of this study is to identify the relationship between the physical activity level and the hepatic steatosis presence, metabolic syndrome and the risk of developing type 2 diabetes mellitus in men. We evaluated retrospectively medical records of 1399 men (40.7 ± 8.18 years old) who participated in the protocol of Preventive Health Check-up at Hospital Israelita Albert Einstein from January to October 2011. According to the results, it is concluded that there is a positive association between low physical activity level and the presence of Hepatic steatosis. The results further demonstrate that, despite the high BMI, blood levels of the subjects remained unchanged. Even without a positive association between these variables, the results showed a high risk behavior for the development of diabetes mellitus type 2.
Cite this paper: de Sá Pinto Montenegro, C. , Marega, M. , de Carvalho, J. , Polito, L. , Pitta, R. , Ceschini, F. , Bocalini, D. and Figueira, A. (2016) Relationship between Physical Activity Level, Hepatic Steatosis Presence, Metabolic Syndrome and the Risk of Developing Type 2 Diabetes in Men. Health, 8, 1778-1787. doi: 10.4236/health.2016.815171.
References

[1]   Pratt, M., Sarmiento, O.L., Montes, F., Ogilvie, D., Marcus, B.H., Perez, L.G., et al. (2012) The Implications of Megatrends in Information and Communication Technology and Transportation for Changes in Global Physical Activity. The Lancet, 380, 282-293.
https://doi.org/10.1016/S0140-6736(12)60736-3

[2]   Kohl, H.W., Craig, C.L., Lambert, E.V., Inoue, S., Alkandari, J.R., Leetongin, G., et al. (2012) The Pandemic of Physical Inactivity: Global Action for Public Health. The Lancet, 380, 294-305.
https://doi.org/10.1016/S0140-6736(12)60898-8

[3]   World Health Organization (2011) Noncommunicable Diseases Country Profiles 2011. World Health Organization, Geneva.

[4]   Hill, J.O. and Wyatt, H.R. (2005) Role of Physical Activity in Preventing and Treating Obesity. Journal of Applied Physiology, 99, 765-770.
https://doi.org/10.1152/japplphysiol.00137.2005

[5]   Fogelholm, M., Stallknecht, B. and Van Baak, M. (2006) ECSS Position Statement: Exercise and Obesity. European Journal of Sport Science, 6, 15-24.
https://doi.org/10.1080/17461390600563085

[6]   Donnelly, J.E., Blair, S.N., Jakicic, J.M., Manore, M.M., Rankin, J.W. and Smith, B.K. (2009) American College of Sports Medicine Position Stand. Appropriate Physical Activity Intervention Strategies for Weight Loss and Prevention of Weight Regain for Adults. Medicine and Science in Sports and Exercise, 41, 459-471.
https://doi.org/10.1249/MSS.0b013e3181949333

[7]   Adams, L.A., Angulo, P. and Lindor, K.D. (2005) Nonalcoholic Fatty Liver Disease. Canadian Medical Association Journal, 172, 899-905.
https://doi.org/10.1503/cmaj.045232

[8]   Cotrim, H.P. (2009) Doença Hepática Gordurosa Não-Alcoólica: História Natural. Gazeta médica da Bahia, 79, 46-47.

[9]   Soler, G.L.N., Silva, A., Silva, V.C.G. and Teixeira, R.J. (2008) Doença hepática gordurosa não-alcoólica: Associação com síndrome metabólica e fatores de risco cardiovascular. Revista da SOCERJ, 21, 94-100.

[10]   Mion Jr., D.., Machado, C.A., Gomes, M.A.M., et al. (2004) IV Brazilian Guidelines in Arterial Hypertension. Arquivos brasileiros de cardiologia, 82, 7.

[11]   Perloff, D., Grim, C., Flack, J,, Frohlich, E.D., Hill, M., McDonald, M., et al. (1993) Human Blood Pressure Determination by Sphygmomanometry. Circulation, 88, 2460-2470.
https://doi.org/10.1161/01.CIR.88.5.2460

[12]   Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA, 285, 2486-2497.
https://doi.org/10.1001/jama.285.19.2486

[13]   Saunders, J.B., Aasland, O.G., Babor, T.F., de la Fuente, J.R. and Grant, M. (1993) Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption-II. Addiction, 88, 791-804.
https://doi.org/10.1111/j.1360-0443.1993.tb02093.x

[14]   Matsudo, S., Araújo, T., Marsudo, V., Andrade, D., Andrade, E. and Braggion, G. (2001) Questinário internacional de atividade f1sica (IPAQ): Estudo de validade e reprodutibilidade no Brasil. Rev bras ativ fís saúde, 6, 5-18.

[15]   Lindström, J. and Tuomilehto, J. (2003) The Diabetes Risk Score. Diabetes Care, 26, 725- 731.
https://doi.org/10.2337/diacare.26.3.725

[16]   Schwarz, P.E., Li, J., Reimann, M., Schutte, A.E., Bergmann, A., Hanefeld, M., et al. (2009) The Finnish Diabetes Risk Score Is Associated with Insulin Resistance and Progression towards Type 2 Diabetes. The Journal of Clinical Endocrinology & Metabolism, 94, 920-926.
https://doi.org/10.1210/jc.2007-2427

[17]   Lindström, J., Peltonen, M., Eriksson, J.G., Aunola, S., Hämäläinen, H., Ilanne-Parikka, P., et al. (2008) Determinants for the Effectiveness of Lifestyle Intervention in the Finnish Diabetes Prevention Study. Diabetes Care, 31, 857-862.
https://doi.org/10.2337/dc07-2162

[18]   Rector, R.S., Thyfault, J.P., Morris, R.T., Laye, M.J., Borengasser, S.J., Booth, F.W., et al. (2008) Daily Exercise Increases Hepatic Fatty Acid Oxidation and Prevents Steatosis in Otsuka Long-Evans Tokushima Fatty Rats. American Journal of Physiology-Gastrointestinal and Liver Physiology, 294, G619-G626.
https://doi.org/10.1152/ajpgi.00428.2007

[19]   Belmonte, M.A., Aoki, M.S., Tavares, F.L. and Seelaender, M.C. (2004) Rat Myocellular and Perimysial Intramuscular Triacylglycerol: A Histological Approach. Medicine and Science in Sports and Exercise, 36, 60-67.
https://doi.org/10.1249/01.MSS.0000106170.26822.55

[20]   Cho, J., Kim, S., Lee, S. and Kang, H. (2015) Effect of Training Intensity on Nonalcoholic Fatty Liver Disease. Medicine and Science in Sports and Exercise, 47, 1624-1634.
https://doi.org/10.1249/MSS.0000000000000595

[21]   Önnerhag, K., Nilsson, P.M. and Lindgren, S. (2013) Insulin Resistance with Impaired Fasting Glucose Increases the Risk of NAFLD. Open Journal of Gastroenterology, 3, 170- 176.
https://doi.org/10.4236/ojgas.2013.33028

[22]   Long, M.T., Pedley, A., Massaro, J.M., Hoffmann, U., Esliger, D.W., Vasan, R.S., et al. (2015) Hepatic Steatosis Is Associated with Lower Levels of Physical Activity Measured via Accelerometry. Obesity, 23, 1259-1266.
https://doi.org/10.1002/oby.21058

[23]   Wang, R.T., Koretz, R.L. and Yee, H.F. (2003) Is Weight Reduction an Effective Therapy for Nonalcoholic Fatty Liver? A Systematic Review. The American Journal of Medicine, 115, 554-559.
https://doi.org/10.1016/S0002-9343(03)00449-2

[24]   Harrison, S.A. and Day, C.P. (2007) Benefits of Lifestyle Modification in NAFLD. Gut, 56, 1760-1769.
https://doi.org/10.1136/gut.2006.112094

[25]   Iughetti, L., Gavioli, S., Bonetti, A. and Predieri, B. (2015) Effects of Exercise in Children and Adolescent with Type 1 Diabetes Mellitus. Health, 7, 1357-1365.
https://doi.org/10.4236/health.2015.710150

[26]   Carvalheira, J.B. and Saad, M.J. (2006) Doenças associadas à resistência à insulina/ hiperinsulinemia, não incluídas na síndrome metabólica. Arquivos Brasileiros de Endocrinologia & Metabologia, 50, 360-367.
https://doi.org/10.1590/S0004-27302006000200022

[27]   Achten, J., Sutedja, D., Johnson, J., Jeukendrup, A., Jones, D. and Elias, E. (2003) Treatment of Nonalcoholic Steatohepatitis: The Effects of Regular Exercise. European Journal of Sport Science, 3, 1-13.
https://doi.org/10.1080/17461390300073404

[28]   Hashida, R., Kawaguchi, T., Bekki, M., Omoto, M., Matsuse, H., Nago, T., et al. (2016) Aerobic vs. Resistance Exercise in Non-Alcoholic Fatty Liver Disease: A Systematic Review. Journal of Hepatology.
https://doi.org/10.1016/j.jhep.2016.08.023

 
 
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