Health  Vol.8 No.15 , December 2016
Serum 1, 25-Hydroxyvitamin D: A Useful Index of Cognitive and Physical Functional Impairment in Healthy Older Adults in Japan: A Pilot Study
Abstract: We enrolled 23 Japanese men (age: 76.0 ± 8.7) and 17 women (age: 78.3 ± 9.3) in this study. The physical function of even a person getting on a wheelchair could be tested in all subjects. Blood was collected by venipuncture and the serum 1, 25-hydroxy vitamin D (1, 25OHD) concentration was measured. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment-Japanese version (MoCA-J) was used for the cognitive function test. Physical function was measured objectively using the Timed UP and Go (TUG) and 4-m walking test (4MWS). A significant positive correlation was found between serum 1, 25OHD and MMSE or MoCA-J. It is expected that an elderly person can maintain a mean serum 1, 25OHD level of about 100 pg/mL for preventing early cognitive disorder. In the present study, a significant positive correlation was found between urinary 25-hydroxy vitamin D (25OHD)/creatinine and MMSE or MoCA-J. Our results showed that urinary 25OHD might be a useful biomarker for predicting cognitive disorder. There was a significant negative correlation between serum 1, 25OHD and TUG or 4MWS. These findings suggest that serum 1, 25OHD levels might serve as a useful index to improve cognitive and physical functional impairment.
Cite this paper: Hasegawa, N. , Mochizuki, M. , Kato, M. , Yamada, T. , Shimizu, N. and Torii, A. (2016) Serum 1, 25-Hydroxyvitamin D: A Useful Index of Cognitive and Physical Functional Impairment in Healthy Older Adults in Japan: A Pilot Study. Health, 8, 1679-1686. doi: 10.4236/health.2016.815163.

[1]   Japanese Orthopedic Association (2010) Guidebook on Locomotive Syndrome. Bunkodo, Tokyo. (In Japanese)

[2]   DeLuca, G.C., Kimball, S.M., Kolasinski, J., Ramagopalan, S.V. and Ebers, G.C. (2013) The Role of Vitamin D in Nervous System Health and Disease. Neuropathology and Applied Neurobiology, 39, 458-484.

[3]   Holick, M.F. (2007) Vitamin D Deficiency. New England Journal of Medicine, 357, 266-281.

[4]   Garcion, E., Wion-Barbot, N., Montero-Menei, C.N., Berger, F. and Wion, D. (2002) New Clues about Vitamin D Functions in the Nervous System. Trends in Endocrinology & Metabolism, 13, 100-105.

[5]   Folstein, M.F., Folstein, S.E. and McHugh, P.R. (1975) “Mini-Mental State”. A Practical Method for Grading the Cognitive State of Patients for the Clinician. Journal of Psychiatric Research, 12, 189-198.

[6]   Gangwar, A.K., Rawat, A., Tiwari, S., Tiwari, S.C., Narayan, J. and Tiwari, S. (2015) Role of Vitamin-D in the Prevention and Treatment of Alzheimer’s Disease. Indian Journal of Physiology and Pharmacology, 59, 94-99.

[7]   Nasredding, Z.S., Phillips, N.A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J.L. and Chertkow, H. (2005) The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool for Mild Cognitive Impairment. Journal of the American Geriatrics Society, 53, 695-699.

[8]   Darwish, H., Zeinoun, P., Ghusn, H., Khoury, B., Tamim, H. and Khoury, S.J. (2015) Serum 25-Hydroxyvitamin D Predicts Cognitive Performance in Adults. Neuropsychiatr. Dis. Treat., 11, 2217-2223.

[9]   Jones, G. (2008) Pharmacokinetics of Vitamin D Toxicity. The American Journal of Clinical Nutrition, 88, 582s-586s.

[10]   Lagari, V., Gómez-Marín, O. and Levis, S. (2013) The Role of Vitamin D in Improving Physical Performance in the Elderly. Journal of Bone and Mineral Research, 28, 2194-2201.

[11]   Podsiadlo, D. and Richardson, S. (1991) The Timed “UP & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons. Journal of the American Geriatrics Society, 39, 142-148.

[12]   Gschwind, Y.J., Bischoff-Ferrari, H.A., Bridenbaugh, S.A., Härdi, I. and Kressig, R.W. (2014) Association between Serum Vitamin D Status and Functional Mobility in Memory Clinic Patient Aged 65 Years and Older. Gerontology, 60, 123-129.

[13]   Shumway-Cook, A., Brauer, S. and Woollacott, M. (2000) Predicting the Probability for Falls in Community-Dwelling Older Adults Using the Timed Up & Go Test. Physical Therapy, 80, 896-903.

[14]   Quach, L., Galica, A.M., Jones, R.N., Procter-Gray, E., Manor, B., Hannan, MT., et al. (2011) The Nonlinear Relationship between Gait Speed and Falls: The Maintenance of Balance, Independent Living, Intellect and Zest in the Elderly of Boston Study. Journal of the American Geriatrics Society, 59, 1069-1073.

[15]   Gluhm, S., Goldstein, J., Loc, K., Colt, A., Liew, C.V. and Corey-Bloom, J. (2013) Cognitive Performance on the Mini-Mental State Examination and the Montreal Cognitive Assessment across the Healthy Adult Lifespan. Cognitive & Behavioral Neurology, 26, 1-5.

[16]   Nissou, M.F., Guttin, A., Zenga, C., Berger, F., Issartel, J.P. and Wion, D. (2014) Additional Clues for a Protective Role on Vitamin D in Neurodegenerative Diseases: 1, 25-Dihydroxyvitamin D3 Triggers an Anti-Inflammatory Response in Brain Pericytes. Journal of Alzheimer’s Disease, 42, 789-799.

[17]   Japanese Orthopedic Association (2013) Locomotive Syndrome Pamphlet.

[18]   Li, Z., Wang, Y., Xie, Y., Yang, Z. and Zhang, T. (2011) Protective Effects of Exogenous Hydrogen Sulfide on Neurons of Hippocampus in a Rat Model of Brain Ischemia. Neurochemical Research, 36, 1840-1849.

[19]   Petersen, K.F., Morino, K., Alves, T.C., Kibbey, R.G., Dufour, S., Sono, S., et al. (2015) Effect of Aging on Muscle Mitochondrial Substrate Utilization in Humans. Proceedings of the National Academy of Sciences of the United States of America, 112, 11330-11334.

[20]   Joseph, A.M., Adhihetty, P.J. and Leeuwenburgh, C. (2016) Beneficial Effects of Exercise on Age-Related Mitochondrial Dysfunction and Oxidative Stress in Skeletal Muscle. The Journal of Physiology, 594, 5105-5123.

[21]   Calgaroto, N.S., Thomé, G.R., da Costa, P., Baldissareli, J., Hussein, F.A., Schmats, R., et al. (2014) Effect of Vitamin D3 on Behavioral and Biochemical Parameters in Diabetes Type 1-Induced Rats. Cell Biochemistry and Function, 32, 502-510.