JBM  Vol.4 No.12 , December 2016
Point-of-Care Testing Using Three Dimensional Optical Biosensor Based on Microfluidic Technology
We have presented a three dimensional optical protein chip that fulfills the demanding for point-of-care diagnostics in terms of ease-of-use (one step assay), miniaturization (5 μl). The artful combination of magnetic nanoparticles on chip and total internal reflection imaging (TIRI) technology permits the sensitive and rapid detection of hs-CRP (high-sensitivity C-reactive protein). The whole test was complete within 10 min using “all in one step” assay with a limit of detection of 0.1 ng/mL hs-CRP. The measuring range for hs-CRP could be extended to 10 ng/mL. The chip can also be used to detect more parameters in blood samples.
Cite this paper: Liu, C. , Cai, H. , Jia, J. , Cao, T. , Li, T. , Ma, T. and Liu, C. (2016) Point-of-Care Testing Using Three Dimensional Optical Biosensor Based on Microfluidic Technology. Journal of Biosciences and Medicines, 4, 56-61. doi: 10.4236/jbm.2016.412009.

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