Colon capsule endoscopy  was approved for reimbursement under the national health insurance system of Japan in 2014. For this reason, detailed examination by capsule endoscopy appears to be useful. However, the capsule excretion rate after recommended bowel preparation reportedly ranges from 70% to 90%, and administration of boosters is also necessary. For dialysis patients   , liquid loading is a problem  -  . At my hospital, the capsule excretion rate after recommended bowel preparation was 53.3% in dialysis patients. In this study, we evaluated the efficacy of bowel preparation with castor oil for improving the capsule excretion rate. In all 20 patients (including four dialysis patients), both capsule transit time and duration of capsule endoscopy were shortened. The results are presented and briefly discussed in this report.
2. Methods and Patients
Subjects and methods: This study included 20 patients who underwent colon capsule endoscopy at Masuko Memorial Hospital since March 2016 (15 men and 5 women with mean age of 62.7 years, including 4 dialysis patients and 4 patients after kidney transplantation).Colon capsule endoscopy was performed with PillCam COLON Capsule (Medtronic, Minneapolis, MN, USA). The recommended protocol of bowel preparation was modified (with administration of castor oil (Himashi Oil: Yoshida Pharmacentical, Japan), and success rates of completing entire colon observation were compared. The modified regimen is shown in Table 1. The changes from the original regimen were as follows: Castor oil was administered immediately after capsule ingestion and as a booster at one and two hours later. The dose of castor oil was 30 mL at each time point. This study was approved by the ethics committee of my hospital, while we obtained written consent from the participants after providing a thorough explanation of the contents and methods of this study.
3. Statistical Analysis
Mann-Whitney U test was performed for comparison between the castor oil-treated and castor oil-untreated groups. A P value of <0.05 was considered significant.
The success rate of completing entire colon observation was 73 patients were included: 46 (63%) in the castor oil-untreated group at our hospital (patient characteristics: 73 men and 29 women with mean age of 60 years, including 30 dialysis patients and 57 non-dialysis patients). The success rates were 43 patients included 30 (69.8%) in the non-dialysis patients and 53.3% in the dialysis patients. On the other hand, the success rate in the castor oil-treated group was 100% (20/20). It was also 100% in both non- dialysis patients (16/16) and dialysis patients (4/4) in this group. Statistically significant differences were observed between patients receiving bowel preparation with and without castor oil (P = 0.001) (Figure 1).
In Japan, colon capsule endoscopy was approved for reimbursement under the national health insurance system in 2014 and is currently performed at many institutions. At my hospital, many dialysis patients are treated on an outpatient basis. Dialysis patients are potentially susceptible to bleeding because of the fragile intestine, impaired platelet function, or oral administration of NSAIDs or anticoagulants. For this reason, detailed examination by capsule endoscopy appears to be useful. Because of the restriction of water intake in dialysis patients, we wanted to reduce the booster dosage as much as possible. Then, we evaluated bowel preparation with castor oil, which is hydrolyzed
Table 1. Bowel preparation regimen.
Figure 1. Statistically significant differences were observed between patients receiving bowel preparation with and without castor oil (P < 0.001).
into glycerol and ricinoleic acid by lipase in the small intestine. Ricinoleic acid causes catharsis by stimulating the small intestine. Although the use of Gastrografin  has been reported, we used castor oil because it is inexpensive and is covered by the national health insurance system of Japan. The capsule excretion rate was 53.3% in dialysis patients treated according to the original protocol of bowel preparation. However, capsule endoscopes were excreted in all patients in the castor oil-treated group, which included only four dialysis patients. The capsule endoscope was excreted even in one of these dialysis patients who was using a wheelchair and was unable to walk. The capsule transit time after bowel preparation with castor oil was shortened, and the booster dosage was also reduced. Thus, the modified protocol of bowel preparation appears to be beneficial for not only dialysis patients, but also many other patients.
Although the number of patients receiving bowel preparation with castor oil was small, entire colon observation was successful even in dialysis patients. Thus, castor oil appears to be useful for bowel preparation for colon capsule endoscopy.
 Gay, G., Delvaux, M., Frederic, M., et al. (2010) Could the Colonic Capsule Pill Cam Colon Be Clinically Useful for Selecting Patients Who Deserve a Complete Colonscopy? Results of Clinical Comparison with Colonscopy in the Perspective of Colorectal Cancer Screening. The American Journal of Gastroenterology, 105, 1076-1086.
 Pilz, J.B., Portmann, S., Peter, S., et al. (2010) Colon Capsule Endoscopy Compared to Conventional Colonscopy under Routine Screening Conditions. BMC Gastroenterology, 10, 66.
 Spada, C., Hasan, C., Riccioni, M.E., et al. (2010) False Positive at Colon Capsule Endoscopy or False Negative at Conventional Colonscopy? Endoscopy, 42, 427-428.
 Hosoe, N., Matsukawa, S., Kanno, Y., et al. (2016) Cross-Sectional Small Intestinal Surveillance of Maintence Hemodialysis Patients Using Video Capsule Endoscopy: SCHEMA Study. Endoscopy International Open, 4, E589-E596.
 Saeed, F., Agrawa, L.N., Greenberg, E., et al. (2011) Lower Gastrointestinal Bleeding in Chronic Hemodialysis Patients. International Journal of Nephrology, 2011, 272535.
 Togashi, K., Fujita, T., Utano, K., et al. (2015) Gastrografin as an Alternative Booster to Sodium Phosphate in Colon Capsule Endoscopy: Safety and Efficacy Pilot Study. Endoscopy International Open, 3, E659-E661.