ABC  Vol.6 No.5 , October 2016
Coumarin and Biscoumarin Inhibit in Vitro Obesity Model
Abstract: Coumarin, sulphonated coumarin, and biscoumarin compounds were examined for their effects on suppressing the adipocyte differentiation in 3T3-L1 cells. Many of them inhibited the adipocyte differentiation in a dose dependent manner, amongst them compounds (7), (28), and (33) significantly suppressed the adipogenic differenti-ation, and also exhibited lipolytic effect on mature adipocytes. The active compounds potentially imitate the AMP-activated protein kinase (AMPK) ligands, there- fore, binding of these compounds with AMPK possibly shuts down the anabolic pathways. Furthermore, these compounds were docked into binding pockets with reasonable pre-dicted binding constants in the low micromolar range. These results indicate that compounds (7), (28), and (33) inhibit adipogenic development in pre- adipocytes, having lipolytic effect on mature adipocytes, and can be potent activators of human AMPK.
Cite this paper: Mukhtar, F. , Stieglitz, K. , Ali, S. , Ejaz, A. , Choudhary, M. , Fakhri, M. , Salar, U. , Khan, K. (2016) Coumarin and Biscoumarin Inhibit in Vitro Obesity Model. Advances in Biological Chemistry, 6, 152-168. doi: 10.4236/abc.2016.65014.

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