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 JBiSE  Vol.9 No.10 B , September 2016
MicroRNAs Play Significant Roles in Pathogenesis of HBV-Related Diseases
Abstract:
MicroRNAs (miRNAs) comprise an important class of small (about 22 nt) conserved nonprotein-coding RNAs that specifically regulate cellular gene expression at the post-transcriptional level. Increasing researches showed that miRNAs have emerged as critical regulators involved in diverse physiological and pathological processes, in-cluding such as proliferation, differentiation and development, apoptosis and patho-gen-host interactions. This review summarizes the crucial roles of miRNAs in replica-tion of the Hepatitis B virus (HBV) and the mechanism underlying dysregulation of miRNAs in HBV-associated diseases. miRNAs are emerged as essential regulators of HBV replication and pathogenesis. To a certain extent, miRNA is a new promising biomarker and useful strategy for diagnosis of HBV-related diseases.
Cite this paper: Chen, G. , Liu, M. , Jiang, Z. , Yu, M. and Wei, S. (2016) MicroRNAs Play Significant Roles in Pathogenesis of HBV-Related Diseases. Journal of Biomedical Science and Engineering, 9, 78-89. doi: 10.4236/jbise.2016.910B011.
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