The childhood cancer is a devastating disease. Globally, approximately 163,300 children develop cancer each year  and 84% of these children live in developing countries  . In Korea, the annual incidence of cancer in children and adolescents was 1700 in 2001- 2005  . The rate of child (under 5) mortality is 3.4/1000 live births  . From 2011 to 2014, there were 7.8 million children and adolescents who were diagnosed as cancer in Bangladesh  .
Studies indicated that children with cancer experienced a loss of hair  , pain, social rejection of peers  , anxiety and depression  , and behavioral disturbances  . In addition, parenting a child with cancer is very distressing, with parents reporting a sense of loss of control, stress, anxiety, depression, sleep disturbance, and uncertainty  , despair followed by fear and guilt   , feelings of hopelessness  , poor psychological well-being  , and feeling deprived of a context of normality  . More specifically, childhood cancer can cause a great deal of physical and emotional stress on mothers  . Some Korean and Bangladeshi mothers believed that chronic illnesses like cancer were a type of fate and punishment or a curse from God   . A study of Martinson et al.  found that Korean mothers of children with cancer felt guilty when they did not receive adequate support from their relatives.
A number of factors contributed to maternal coping in response to stressful events. Studies confirmed that education levels were positively correlated with an active coping style  -  . The age of both fathers and children and the length of time since diagnosis showed direct correlations to paternal uncertainty and coping  . Besides these factors, two significant factors contributing to maternal coping are uncertainty and perceived social support, based on Mishel’s Uncertainty in Illness Theory (MUI)  .
Bowers  found that uncertainty had a direct effect on emotion-focused coping, regardless of the appraisal of the uncertainty as danger or opportunity. “Chronicity and uncertainty” are responsible for both perceived stress and coping strategies  . Another study revealed that parents of young children with chronic conditions with intermittently unpredictable symptoms reported significantly more distress than parents of children with more predictable symptoms  . However, a study by Lee, Yoo, and Yoo  found that parenting stress was related to ambiguity, lack of clarity, and lack of information, but not related to unpredictability. A study by Bowers  found that social support was significantly associated with danger and opportunity. Perceived social support contributed to parental distress  , stress    , and maternal psychological adjustment   . Martinson et al.  identified that most Korean mothers received support from their spouse, physicians, nurses, family, neighbors, friends, and religious practitioners. However, social support did not demonstrate any potential effect on mothers’ distress 5 years after their child’s diagnosis with cancer (T4)  .
Although there have been many studies as assessing psychological adjustment and coping for parents of children with cancer, relatively few have highlighted the cognitive state of uncertainty and illness-related distress, and social support were associated with maternal coping. Moreover, previously published studies were conducted using diverse families from different cultures, and presented inconsistent findings. In addition, in the existing literature, there are no studies on maternal uncertainty, social support, and maternal coping based on Mishel’s Uncertainty theory. Therefore, it is necessary to investigate factors affecting maternal coping among mothers of children with cancer. Information obtained from this study can guide interventions for pediatric oncology nurses to help mothers manage uncertainty and enhance effective coping when their child is diagnosed with cancer.
The conceptual framework of this study was guided by the Uncertainty in Illness Theory (UIT)  . The theory proposes that uncertainty exists in illness situations that are ambiguous, complex, and unpredictable. The theory explains how individuals cognitively process illness-related stimuli and how they structure meaning around those events  . The theory focuses on the ill individual and the parent or family of that individual. According to the UIT, “uncertainty is the inability to determine the meaning of illness-related events, occurring when the decision maker is unable to assign definite value to objects or events, or is unable to predict outcomes accurately”  . It is a cognitive state created when an individual cannot adequately structure or categorize an illness event because of insufficient signals  . In this study, maternal uncertainty can be defined as the inability of the decision maker (the mother) to adequately structure, categorize, and determine the meaning of illness-related events. Structure providers, such as social support, influence uncertainty, directly or indirectly. Social support directly influences uncertainty by providing information and guidance to temper ambiguity, complexity, lack of information, and unpredictability  . In this study, perceived social support is the mother’s perception of whether she receives adequate support from family, friends, and significant others. Maternal coping is an outcome variable in this study. Maternal coping is the specific effort, both behavioral and psychological, that mothers employ to master, tolerate, and reduce stressful events. According to this theory, the researchers assume that maternal coping can be predicted by maternal uncertainty and perceived social support. Figure 1 is the conceptual framework of this study (Figure 1).
2.1. Setting and Participants
Participants were recruited from a single health center in Korea. The mothers in this study were the primary caregiver of their children. The study was conducted from December 2013 to April 2014 at inpatient and outpatient departments for children’s care delivery. The sample size in this study was estimated by using statistical power analysis. Using G-power 3.13 for multiple linear regression analysis 80% power was produced with 58 participants with a medium effect size (f2 = 0.25) and α = 0.05 (Cohen, 1988). However, the final sample for this study consisted of 59 mothers of children with can-
Figure 1. Conceptual framework of the study.
cer. A purposive sample of mothers was invited to complete the self-report questionnaire after the research study was announced by doctors. All mothers met the following inclusion criteria: 1) have adequate perception to person and place; 2) able to understand and speak Korean; 3) have a child aged 2 - 6 years old who was admitted to the hospital with a cancer diagnosis (and no additional diagnoses at least 1 month prior to the study); and 4) the child with a cancer diagnosis was undergoing treatment. Multicultural mothers were excluded from this study.
2.2. Ethical Considerations
This research was approved by Institutional Review Board, Yonsei Health System, Severance Hospital, 50-1, Yonseiro, Seodaemungu, Seoul, Korea and Yonsei Cancer Center, Yonsei Health System, Severance Hospital, 50-1, Yonseiro, Seodaemungu, Seoul, Korea. Written consent form obtained from the mothers. All mothers were informed about the study purposes and methods. A small gift was given to the participants as compensation.
Data were collected by using four questionnaires: 1) Demographic Data Questionnaire, 2) Parent’s Perception of Uncertainty Scale (PPUS), 3) Multidimensional Scale of Perceived Social Support (MSPSS), and 4) Coping Health Inventory for Parents (CHIP).
2.4. The Demographic Data Questionnaire
The Demographic Data Questionnaire was designed by the researcher based on the literature reviewed. The characteristics of mothers consisted of age, education, religion, number of children, occupation, monthly family income, and housing status. The characteristics of children consisted of age, sex, siblings, diagnosis, time since diagnosis, relapse of cancer, and the duration of treatment.
Maternal uncertainty was measured using the PPUS. The original items of the PPUS  were derived from Mishel’s Uncertainty in Illness Scale for Adults (MUIS-A). The PPUS consists of 31items with four subscales: ambiguity (13 items), lack of clarity (9 items), lack of information (5 items), and unpredictability (4 items). All items were on 4-point Likert-type scale, ranging from strongly disagree (1) to strongly agree (4). The range of possible scores on the 31-items PPUS is 31 to 124, with a higher score indicating greater uncertainty. The Cronbach’s alpha of the total PPUS was 0.86  for the Korean version, the Cronbach’s alpha was 0.86  .
Perceived social support was measured using the MSPSS  . The MSPSS consists of 12items with three domains: support from family (4items), friends (4items), and from a significant other (4items). All items were on a 5-point Likert-type scale, ranging from strongly disagree (1) to strongly agree (5). Total and subscale scores range from 1 - 5, with higher scores suggesting greater levels of perceived social support. The alpha coefficient for the total scale was 0.93  ; for the Korean version, the Cronbach’s alpha was 0.85  .
Maternal coping was measured by using the CHIP  , which assesses parents’ appraisal of behaviors they use to manage their family life when they have a child who is seriously and/or chronically ill. The CHIP consists of 45 items. In this study, 36 items were used with three subscales: efforts for an optimistic definition of the situation (16 items), efforts for emotional stability (15 items), and efforts to resolve the problem (5 items). All items were scored on a 4-point Likert-type scale, ranging from strongly disagree (1) to strongly agree (4). The range of possible scores on the 36-item CHIP was 36 to 120, with a higher score indicating greater maternal coping. The overall reliability coefficient was 0.88  . This instrument was back translated and revised into a Korean version by Sung (2003). The Cronbach’s alpha for the 36-item scale was 0.92  .
2.8. Data Collection
A descriptive approach was used. Data were collected through self-report questionnaires. After getting permission from the Director of the Yonsei Cancer Center, the research assistant met with the nurse manager of the selected ward and the participants who met the inclusion criteria. The research assistant introduced herself and briefly explained the purpose of the study. The research assistant explained informed consent and that mother had a right to refuse to participate in the study at any time. The research assistant asked participants to provide answers in accordance with the questions being asked. The interview time ranged from 30 - 40 minutes. The research assistant checked the completeness of the questionnaires. The data were collected from November2014 to January 2015.
2.9. Data Analysis
Both descriptive and inferential statistics were used to analyze the data. Descriptive statistics were used to analyze the characteristics of mothers and their children. The differences between characteristics and maternal coping were analyzed using T-tests and one-way analyses of variance. The relationships between maternal uncertainty, perceived social support, and maternal coping were analyzed using Pearson’s Product Moment correlation coefficients. A hierarchical multiple regression model was used to analyze if maternal uncertainty and perceived social support can predict maternal coping in mothers of children with cancer.
Fifty-nine mothers of children with cancer with a mean age of 35.34 ± 4.68 years (range, 21 - 46) participated in this study. More than half of the mothers had a college education (59.3%) and a majority were religious (69.5%). A majority of mothers had more than two children (69.8%). A large number of mothers had no paid employment (83.1%), however, the average monthly family income was 527.55 ± 463.31 million Korean Won. Half of the mothers did not own their homes (instead, rented or leased a home). A majority of mothers got information from their health care providers (64.4%) (Table 1).
3.2. Characteristics of Children
The average age of children was 4.27 ± 1.59 years old. Thirty-five (59.3%) children were male and a majority had a sibling (69.5%). Approximately 55.9% children had solid cancer (brain tumor, neuroblastoma) and others types of cancer. The mean time since diagnosis was 2.29 ± 0.87 years and a large number of children had not relapse condition (76.3%). The average treatment period was 18.68 ± 1.11 months (Table 2).
3.3. Maternal Uncertainty, Perceived Social Support, and Maternal Coping
Table 3 shows that the descriptive statistics of each independent variable and the dependent variable. The mean of the maternal uncertainty was 67.03 (SD = 9.92); scores ranged from 46 to 87. The mean of the ambiguity subscale was 28.03(SD = 5.41) and scores of this subscale ranged from 15 to 36. The mean of the lack of clarity subscale was 19.02 (SD = 2.91) and scores ranged from 11 to 24. The average of the lack of information subscale was 10.31 (SD = 1.90) and scores ranged from 5 to 14. The mean of
Table 1. General characteristics of mothers (N = 59).
Table 2. General characteristics of children (N = 59).
Table 3. Descriptive statistics of maternal uncertainty, perceived social support, and maternal coping in mothers of children with cancer (N = 59).
the unpredictability subscale was 9.68 (SD = 1.66) and scores ranged from 7 to 14. The mean of the perceived social support scale was 46.22 (SD = 6.31) and scores ranged from 29 to 60. The mean of the support from family subscale was 16.81 (SD = 2.50) and scores ranged from 8 to 20. The mean of the support from friends subscale was 15.25 (SD = 2.63) and scores ranged from 4 to 20. The mean of the support from significant others subscale was 14.15 (SD = 3.16) and scores ranged from 7 to 20. The average of the maternal coping score was 104.73 (SD = 11.72) and scores ranged from 77 to 137. The mean of the effort for optimistic definition of the situation subscale was 49.08 (SD = 5.69) and scores ranged from 38 to 62. The mean of the effort for emotional stability subscale was 40.12 (SD = 7.50) and scores ranged from 25 to 70. The mean of the effort to resolve the problem was 15.53 (SD = 2.17) and scores ranged from 10 to 20.
3.4. Differences in Maternal Uncertainty, Perceived Social Support, Maternal Coping and Demographic Characteristics of Mothers and Their Children
Table 4 and Table 5 show the differences in maternal uncertainty, perceived social support, maternal coping and characteristics of mothers and their children. Maternal uncertainty was statistically significantly different by maternal education (t = 4.004, p = 0.024) and by the child’s relapse status (t = 2.826, p = 0.006). There was a statistically significant difference in perceived social support based on a mother’s employment status (t = 2.390, p = 0.020). Maternal coping also significantly varied based on maternal employment status (t = 2.258, p = 0.028).
Table 4. Differences in maternal uncertainty, perceived social support, and maternal coping in mothers of children with cancer according to demographic characteristics (N = 59).
Table 5. Descriptive statistics independent t-tests, and ANOVAs among characteristics of mothers and their children and maternal coping in mothers of children with cancer (N = 59).
3.5. Relationships among Maternal Uncertainty, Perceived Social Support, and Maternal Coping
Table 6 shows a statistically significant negative relationship between maternal uncertainty and maternal coping in mothers of children with cancer (r = −0.398, p = 0.002). There was a statistically significant moderate and positive relationship between perceived social support and maternal coping in mothers of children with cancer (r = 0.527, p = 0.000).
3.6. Factors Affecting Maternal Coping
After testing the assumption of regression analysis, it was found that all of the assumptions were acceptable. Hierarchical multiple regression analysis was performed to identify the main factors affecting maternal coping in mothers of children with cancer. The model included maternal uncertainty, perceived social support, and general variables, such as maternal employment status, and sources of information, that were significantly related to maternal coping in the prior analyses (Table 7). The results indicated that maternal uncertainty and perceived social support were significant predictors of maternal coping in mothers of children with cancer. Maternal uncertainty and perceived social support together explained 35% of the variance in the maternal coping in mothers of children with cancer (R2 = 0.353, F = 15.255, p = 0.000). The regression coefficients of maternal uncertainty and perceived social support were −0.283 (t = -2.544, p = 0.014) and 0.455 (t = 4.097, p = 0.000), respectively (Figure 2).
The present study examined factors that affect maternal coping in Korean mothers of children with cancer. The present findings contribute to the ability to predict and understand maternal coping in mothers of children with cancer. According to the UIT, uncertainty and social support are the major factors that determine a parent’s coping. In the present study, maternal uncertainty and perceived social support predicted maternal coping in mothers of children with cancer. Maternal uncertainty and perceived
Table 6. Pearson’s product moment correlation between maternal uncertainty, perceived social support and maternal coping in mothers of children with cancer (N = 59).
*p < 0.05, **p < 0.01.
Table 7. A hierarchical multiple regression of maternal uncertainty and perceived social support with maternal coping in mothers of children with cancer (N = 59).
Adjusted R2 = 0.387.
Figure 2. Regression coefficients and multiple correlations of maternal uncertainty and perceived social support maternal coping in mothers of children with cancer.
social support together explained 35% of the variance in the maternal coping. The results are also consistent with other studies among different populations   -  .
It was found that maternal uncertainty had a significant effect on maternal coping in mothers of children with cancer. The regression coefficient of maternal uncertainty was −0.283 (t = −2.544, p = 0.014), indicating that uncertainty is a stressor for Korean mothers of children with cancer, which puts these mothers at a greater risk for negative maternal coping. This result is consistent with the theory stating that uncertainty in illness is the inability to determine the meaning of illness-related events; this occurs in situations where the decision-maker is unable to assign a definite value to objects or events or is unable to predict an outcome due to a lack of sufficient cues  . The results are also consistent with other studies that were conducted with diverse populations. Lin Lin  found that lower parental uncertainty was associated with improved parental coping in Taiwanese parents of children with cancer. Moreover, a study by Madeo et al.  indicated that when parents perceive greater uncertainty, they perceive less control over their child’s condition. Furthermore, Sterken  found that parents’ perceptions of uncertainty were significantly related to fathers’ coping styles. A study of Lipinski et al.  found that uncertainty was an independent predictor of parental coping and the regression coefficient of uncertainty was 0.20 (SE = 0.070, p = 0.004). The results of the present study are not consistent with a study by Lee et al. which found that uncertainty did not significantly predict distress  . Tak and McCubbin also found a non-significant direct effect between family stress and coping among mothers of children with congenital heart disease  .
Perceived social support, as defined in this study, was the mother’s perception as to whether she received adequate support from family, friends and significant others. Thus, if a mother perceived greater social support, she might also be likely to report a higher level of coping. In the present study, perceived social support significantly contributed to maternal coping in Korean mothers of children with cancer. The magnitude of perceived social support coefficient was 0.455 (t = 4.097, p = 0.000). The soundness of the conceptual model of maternal coping in mothers of children with cancer derived from Mishel’s uncertainty in illness theory was supported by the present study. The result is consistent with those from previous studies. A study found that maternal perceived social support significantly contributed to the prediction of maternal coping in mothers of children with congenital heart disease (β = 0.39, p = 0.000), accounting for 15% of the variance  . Han found a significant relationship between perceived social support and coping in mothers of children with cancer (r = 0.48, p < 0.000)  . Beltrao et al. indicated that mothers perceived that support from their family members, health care team, and friends helped them cope with their children’s disease and its effects  . Another study found that parents of children with life-threatening and non- life-threatening illnesses reported significant differences in social support and coping behavior  . Lee et al. found that social support explained 33.3% of parenting stress  . Study of Tak and McCubbin indicated that interventions should be directed at enhancing social support, as there is empirical evidence that perceived social support is a predictor of family coping  .
4.1. Implications for Nursing Practice
Nurses can provide informational and emotional support to mothers, as mothers need support in coping with the constant uncertainty of the illness-related situation.
4.2. Implication for Future Studies
Further studies are necessary to explain the causal relationships among the UIT variables. An intervention design also may help mothers feel more support and less uncertainty.
A measurement error was likely to have influenced the results. Regarding answering the item of monthly income, the participants were rigid to answer this question. In addition, the questionnaire was missing an item regarding marital status, which may contribute to maternal coping. In terms of generalizability, the subjects were limited to mothers of children with cancer admitted in to a specialized Korean hospital.
This study demonstrated the implication of the Mishel’s UIT in examining factors affecting maternal coping in mothers of children with cancer. The findings indicated that maternal uncertainty and perceived social support were significant determinants of maternal coping. Therefore, it is suggested that nurses actively participate in facilitating information and provide support to mothers. Providing support may alleviate uncertainty and assist mothers in coping with the diagnosis and treatment of their children. Mothers need information about what is happening and what to expect before and after treatment, and advice and encouragement that change the level of uncertainty and improve maternal coping when their children are diagnosed with and receiving treatment for cancer.
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