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 IJMPCERO  Vol.5 No.3 , August 2016
Assessment the Optimal Effect of Time of Repetition: Extrinsic Pulse Parameter on Gd-DTPA Enhanced, Spin-Echo T1-Weighted MR Images under Low Magnetic Field Strength
Abstract: The contrast agent concentration, the time of repetition (TR) and magnetic field strength are significant parameters that influence for the accurate signal intensity (SI) in quantitative Magnetic Resonance Imaging (MRI). Therefore, this study was conducted to investigate and refine the dependence and the optimal effect of Time of Repetition (TR) on the relationship between signal intensity and Gd-DTPA (Gadolinium-diethylene-triaminepenta-acetic acid) concentration, after applying two-dimensional (2D) Spin Echo (SE) pulse sequence under low-field MRI. In addition to that, the optimal concentration of Gd-DTPA at given sequence parameters at low-field MRI was also evaluated. A water-filled phantom was constructed for a range of Gd-DTPA concentrations (0 - 6 mmol/L) and the mean signal intensities (SIs) were assessed in the defined region of interest on T1-weighted images with different TR values (40 - 2000 ms). The generated signal-concentration curves for Gd-DTPA revealed that increasing TR was associated with the increase of the overall SIs and the maximum relationship between SI to concentration. Moreover, the required Gd-DTPA concentration to produce the maximum SI was associated to decrease with the increase of TR. In addition to this, the application of beyond 100 ms TR values in this study with relatively higher concentrations (beyond 1 - 2 mmol/L) has resulted predominantly non-linear patterns in the signal-concentration curves and it appears the saturation or decay of the SIs due to T2 effect. From these results, it can be suggested that the selection of relatively lower Gd-DTPA concentration (<1


mmol/L) with less than 800 ms (<800 ms) TR values can produce a better linear relationship between the concertation and SIs in T1-weighted SE low field contrast-enhanced MRI. Furthermore, this study also outlined the significance and necessity of the optimization of TR in SE sequence in low field MRI prior to a particular examination.

Keywords: Gd-DTPA Concentration, Spin Echo Pulse Sequence, Signal Intensity, Time of Repetition, T1-Weighted Images, Low Field MRI
Cite this paper: Weerakoon, B. , Osuga, T. and Konishi, T. (2016) Assessment the Optimal Effect of Time of Repetition: Extrinsic Pulse Parameter on Gd-DTPA Enhanced, Spin-Echo T1-Weighted MR Images under Low Magnetic Field Strength. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 5, 196-203. doi: 10.4236/ijmpcero.2016.53021.
References

[1]   Rohrer, M., Bauer, H., Mintorovitch, J., Requardt, M. and Weinmann, H.-J. (2005) Comparison of Magnetic Properties of MRI Contrast Media Solutions at Different Magnetic Field Strengths. Investigative Radiology, 40, 715-724.
http://dx.doi.org/10.1097/01.rli.0000184756.66360.d3

[2]   Riyahi-Alam, S., Haghgoo, S., Gorji, E. and Riyahi-Alam, N. (2015) Size Reproducibility of Gadolinium Oxide Based Nanomagnetic Particles for Cellular Magnetic Resonance Imaging: Effects of Functionalization, Chemisorption and Reaction Conditions. Iranian Journal of Pharmaceutical Research, 14, 3-14.

[3]   Kanakia, S., Toussaint, J.D., Chowdhury, S.M., Lalwani, G., Tembulkar, T., Button, T., et al. (2013) Physicochemical Characterization of a Novel Graphene-Based Magnetic Resonance Imaging Contrast Agent. International Journal of Nanomedicine, 8, 2821-2833.

[4]   Nazarpoor, M. (2009) The Effect of Repetition Time on the Maximum Linear Relationship between Contrast Agent Concentration and Signal Intensity on T1-Weighted Image Using Inversion Recovery (IR) Sequence. Iranian Journal of Radiology, 6, 247-252.

[5]   Shahbazi-Gahrouei, D., Williams, M. and Allen, B.J. (2001) In Vitro Study of Relationship between Signal Intensity and Gadolinium-DTPA Concentration at High Magnetic Field Strength. Australasian Radiology, 45, 298-304.
http://dx.doi.org/10.1046/j.1440-1673.2001.00924.x

[6]   Nazarpoor, M., Poureisa, M. and Daghighi, M.H. (2012) Comparison of Maximum Signal Intensity of Contrast Agent on t1-Weighted Images Using Spin Echo, Fast Spin Echo and Inversion Recovery Sequences. Iranian Journal of Radiology, 10, 27-32.
http://dx.doi.org/10.5812/iranjradiol.5452

[7]   Curvo-Semedo, L. and Caseiro-Alves, F. (2011) MR Contrast Agents. In: Gourtsoyiannis, N.C., Ed., Clinical MRI of the Abdomen, Springer-Verlag Berlin Heidelberg, 17-39.

[8]   Saharkhiz, H., Gharehaghaji, N., Nazarpoor, M., Mesbahi, A. and Pourissa, M. (2014) The Effect of Inversion Time on the Relationship between Iron Oxide Nanoparticles Concentration and Signal Intensity in T1-Weighted MR Images. Iranian Journal of Radiology, 11, Article ID: e12667.
http://dx.doi.org/10.5812/iranjradiol.12667

[9]   Sakuma, H., O’Sullivan, M., Lucas, J., Wendland, M.F., Saeed, M., Dulce, M.C., et al. (1994) Effect of Magnetic Susceptibility Contrast Medium on Myocardial Signal Intensity with Fast Gradient-Recalled Echo and Spin-Echo MR Imaging: Initial Experience in Humans. Radiology, 190, 161-166.
http://dx.doi.org/10.1148/radiology.190.1.8259398

[10]   Lanczi, L.I., Balázs, E., Beresova, M., Tircsó, G. and Berényi, E.L. (1970) Comparing Low-Field and High Field Relaxometry Properties of Solutions and Clinically Used Contrast Agents. European Congress of Radiology 2013.

[11]   Lindegaard, H., Vallø, J., Hørslev-Petersen, K., Junker, P. and Østergaard, M. (2001) Low Field Dedicated Magnetic Resonance Imaging in Untreated Rheumatoid Arthritis of Recent Onset. Annals of the Rheumatic Diseases, 60, 770- 776.
http://dx.doi.org/10.1136/ard.60.8.770

[12]   Pope, T., Bloem, H.L., Beltran, J., Morrison, W.B. and Wilson, D.J. (2014) Musculoskeletal Imaging. Elsevier Health Sciences, Makati City.

[13]   Klein, H.-M. (2016) Clinical Low Field Strength Magnetic Resonance Imaging: A Practical Guide to Accessible MRI. Springer International Publishing, Switzerland.
http://dx.doi.org/10.1007/978-3-319-16516-5

[14]   Nazarpoor, M., Poureisa, M. and Daghighi, M.H. (2013) Effect of Echo Time on the Maximum Relationship between Contrast Agent Concentration and Signal Intensity Using FLAIR Sequence. Iranian Journal of Medical Physics, 10, 59-67.

[15]   Bjørnerud, A. (2008) The Physics of Magnetic Resonance Imaging. Department of Physics, University of Oslo, Oslo.

[16]   Poh, C.K., Hardy, P.A., Liao, Z., Clark, W.R. and Gao, D. (2003) Nonintrusive Characterization of Fluid Transport Phenomena in Hollow-Fiber Membrane Modules Using MRI: An Innovative Experimental Approach. Membrane Science and Technology, 8, 89-122.
http://dx.doi.org/10.1016/S0927-5193(03)80008-6

[17]   Brix, G., Kolem, H., Nitz, W.R., Bock, M., Huppertz, A., Zech, C.J., et al. (2008) Basics of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy. In: Reiser, M., Semmler, W. and Hricak, H., Eds., Magnetic Resonance Tomography, Springer-Verlag, Berlin, 92-108.

[18]   Jung, B.A. and Weigel, M. (2013) Spin Echo Magnetic Resonance Imaging. Journal of Magnetic Resonance Imaging, 37, 805-817.
http://dx.doi.org/10.1002/jmri.24068

[19]   Estelrich, J., Sánchez-Martín, M.J. and Busquets, M.A. (2015) Nanoparticles in Magnetic Resonance Imaging: From Simple to Dual Contrast Agents. International Journal of Nanomedicine, 10, 1727-1741.

[20]   Giers, M.B., McLaren, A.C., Plasencia, J.D., Frakes, D., McLemore, R. and Caplan, M.R. (2013) Spatiotemporal Quantification of Local Drug Delivery Using MRI. Computational and Mathematical Methods in Medicine, 2013, Article ID: 149608.
http://dx.doi.org/10.1155/2013/149608

[21]   Chen, X., Astary, G.W., Sepulveda, H., Mareci, T.H. and Sarntinoranont, M. (2008) Quantitative Assessment of Macromolecular Concentration during Direct Infusion into an Agarose Hydrogel Phantom Using Contrast-Enhanced MRI. Magnetic Resonance Imaging, 26, 1433-1441.
http://dx.doi.org/10.1016/j.mri.2008.04.011

[22]   Li, S.K., Jeong, E.K. and Hastings, M.S. (2004) Magnetic Resonance Imaging Study of Current and Ion Delivery into the Eye during Transscleral and Transcorneal Iontophoresis. Investigative Ophthalmology & Visual Science, 45, 1224- 1231.
http://dx.doi.org/10.1167/iovs.03-0821

[23]   Osuga, T. and Han, S. (2004) Proton Magnetic Resonance Imaging of Diffusion of High- and Low-Molecular-Weight Contrast Agents in Opaque Porous Media Saturated with Water. Magnetic Resonance Imaging, 22, 1039-1042.
http://dx.doi.org/10.1016/j.mri.2003.07.004

[24]   Buckley, D. and Parker, G.J. (2005) Measuring Contrast agent Concentration in T1-Weighted Dynamic Contrast-En- hanced MRI. In: Jackson, A., Buckley, D.L. and Parker, G.J.M., Eds., Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology, Springer, Berlin, 69-79.
http://dx.doi.org/10.1007/3-540-26420-5_5

[25]   Hathout, G. and Jamshidi, N. (2012) Parameter Optimization for Quantitative Signal-Concentration Mapping Using Spoiled Gradient Echo MRI. Radiology Research and Practice, 2012, Article ID: 815729.
http://dx.doi.org/10.1155/2012/815729

[26]   Sasaki, M., Shibata, E., Kanbara, Y. and Ehara, S. (2005) Enhancement Effects and Relaxivities of Gadolinium-DTPA at 1.5 versus 3 Tesla: A Phantom Study. Magnetic Resonance in Medical Sciences, 4, 145-149.
http://dx.doi.org/10.2463/mrms.4.145

[27]   Korb, J.P. and Bryant, R.G. (2002) Magnetic Field Dependence of Proton Spin-Lattice Relaxation Times. Magnetic Resonance in Medicine, 48, 21-26.
http://dx.doi.org/10.1002/mrm.10185

[28]   Reeder, S.B., Smith, M.R. and Hernando, D. (2016) Mathematical Optimization of Contrast Concentration for t1-Weighted Spoiled Gradient Echo Imaging. Magnetic Resonance in Medicine, 75, 1556-1564.
http://dx.doi.org/10.1002/mrm.25744

[29]   Brasch, R.C., Weinmann, H.J. and Wesbey, G.E. (1984) Contrast-Enhanced NMR Imaging: Animal Studies Using Gadolinium-DTPA Complex. American Journal of Roentgenology, 142, 625-630.
http://dx.doi.org/10.2214/ajr.142.3.625

 
 
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