Back
 AID  Vol.6 No.3 , September 2016
Chronic Meningococcemia
Abstract: Neisseria meningitidis is a gram-negative diplococcus which causes invasive disease. The most frequent clinical manifestations caused by infection with this pathogen, are meningitis and fulminant septic shock. More benign forms with a subacute or chronic pattern are rare but still can evolve to meningitis and have a fatal outcome. This entity is difficult to recognize, as febrile erythema with otherwise good general condition may simulate other diseases, namely viral infections. The authors reported the cases of two healthy young adults who were misdiagnosed with a viral infection. What they really had was a meningococcemia without meningitis presenting with mild and unspecific symptoms, such as, intermittent fever and a discrete macular rash. We pretend to highlight this rare, unspecific and heterogeneous symptoms which can provoke negligence of a potentially life threatening condition.
Cite this paper: Ferraz, R. , Ceia, F. , Duro, R. , Carvalho, A. , Andrade, P. , Silva, S. and Sarmento, A. (2016) Chronic Meningococcemia. Advances in Infectious Diseases, 6, 97-101. doi: 10.4236/aid.2016.63012.
References

[1]   Coureuil, M., et al. (2013) Pathogenesis of Meningococcemia. Cold Spring Harbor Perspectives in Medicine, 3, a012393.

[2]   Sabatini, C., Bosis, S., Semino, M., Senatore, L., Principi, N. and Esposito, S. (2012) Clinical Presentation of Meningococcal Disease in Childhood. Journal of Preventive Medicine and Hygiene, 56-119.

[3]   Thompson, M.J., et al. (2006) Clinical Recognition of Meningococcal Disease in Children and Adolescents. Lancet, 367, 397-403.
http://dx.doi.org/10.1016/S0140-6736(06)67932-4

[4]   Tan, L.K., Carlone, G.M. and Borrow, R. (2010) Advances in the Development of Vaccines against Neisseria meningitidis. New England Journal of Medicine, 362, 1511-1520.
http://dx.doi.org/10.1056/NEJMra0906357

[5]   Poizeau, F., et al. (2015) Meningococcémie sans méningite: à propos de deux observations. Revue de Médecine Interne.

[6]   Dupin, N., et al. (2012) Chronic Meningococcemia Cutaneous Lesions Involve Meningococcal Perivascular Invasion through the Remodeling of Endothelial Barriers. CID, 54, 1162-1165.
http://dx.doi.org/10.1093/cid/cis120

[7]   Kernéis, S., Mahé, E., Heym, B., Tardy, V.S., Bourgeois, F. and Hanslik, T. (2009) Chronic Meningococcemia in a 16- Year-Old Boy: A Case Report. Cases Journal, 2, 7103.
http://dx.doi.org/10.4076/1757-1626-2-7103

[8]   Harwood, C.A., Stevens, J.C., Orton, D., Bull, R.C., Paige, D., Lessing, M.P., Mortimer, P.S., Marsden, R.A. and Cerio, R. (2005) Chronic Meningococcaemia: A Forgotten Meningococcal Disease. British Journal of Dermatology, 153, 669-671.
http://dx.doi.org/10.1111/j.1365-2133.2005.06771.x

[9]   Hazelzet, J.A. (2005) Diagnosing Meningococcemia as a Cause of Sepsis. Pediatric Critical Care Medicine, 6, S50- S54.
http://dx.doi.org/10.1097/01.PCC.0000161947.57506.D6

[10]   (2015) Meningococcal Disease. Centers for Disease Control and Prevention Epidemiology and Prevention of Vaccine-Preventable Diseases, 13th Edition.

[11]   Fasano, M.B., Sullivan, K., Ibsen, L. and Winkelstein, J.A. (1993) Chronic Meningococcemia in a Child with a Deficiency of the Sixth Component of Complement. Pediatric Allergy and Immunology, 4, 214-216.
http://dx.doi.org/10.1111/j.1399-3038.1993.tb00094.x

[12]   Boos, C., Daneshvar, C., Hinton, A. and Dawes, M. (2004) An Unusual Case of Chronic Meningitis. BMC Family Practice, 5, 21.
http://dx.doi.org/10.1186/1471-2296-5-21

 
 
Top