ABC  Vol.1 No.2 , August 2011
The effects of consumption of raw garlic on serum lipid level, blood sugar and a number of effective hormones on lipid and sugar metabolism in hyperglycemic and/or hyperlipidemic individuals ——Benefit of raw garlic consumption
Abstract: Diabetes mellitus is one of the worldwide largest growing metabolic diseases. In this study the effects of consumption of raw garlic on serum lipid level, blood sugar and a number of effective hormones on lipid and sugar metabolism (thyroid hormones and insulin) in individuals either with high level of blood sugar or lipid were investigated. Eighty five volunteers having following clinical history enrolled in the study: Group 1: having blood sugar more than 126 mg/dl (30 vo-lunteers); Group 2: having cholesterol higher than 245 mg/dl (30 volunteers); Group 3: having blood sugar over 126 mg/dl and cholesterol more than 245 mg/dl (25 volunteers). In group 1, there wasn’t a sig-nificant differences between biochemical factors be-fore and after garlic consumption, whereas, in the second group after 6 weeks of garlic consumption a decline in cholesterol (P < 0.001), FBS and TG (P < 0.01) was observed but HDL-C (P < 0.001) was in-creased. Six weeks after termination of garlic con-sumption, cholesterol (P < 0.001), FBS and TG (P < 0.05) were in- creased and HDL-C (P < 0.01) was de-creased. In the third group, total cholesterol (P < 0.001), FBS (P < 0.01) and HbA1c decreased while HDL-C was in- creased. Other factors, including thy-roid hormones (T3, T4), TSH and insulin showed no significant alte- ration. In conclusion our results shown that raw garlic consumption can reduce the FBS and Lipid in hyperglycemic and/or hyperlipidemic individuals.
Cite this paper: nullMahmoodi, M. , Zijoud, S. , Hassanshahi, G. , Toghroli, M. , Khaksari, M. , Hajizadeh, M. and Mirzajani, E. (2011) The effects of consumption of raw garlic on serum lipid level, blood sugar and a number of effective hormones on lipid and sugar metabolism in hyperglycemic and/or hyperlipidemic individuals ——Benefit of raw garlic consumption. Advances in Biological Chemistry, 1, 29-33. doi: 10.4236/abc.2011.12005.

[1]   Mutalik, S., Sulochana, B., Chetana, M., Udupa, N., Uma Devi, P. (2003) Preliminary studies on acute and subacute toxicity of an antidiabetic herbal preparation, Dianex. Indian Journal of Experimental Biology, 41, 316-320.

[2]   Bailey, C.J., Flatt, P.R., Deacon, C.F., Shaw, C. and Con-lon, J.M. (1986) Substance P, neurokinin A, vasoactive intestinal polypeptide and gastrin releasing peptide in the intestine and pancreas of spontaneously obese-diabetic mice. Regulatory Peptides, 16, 339-348. doi:10.1016/0167-0115(86)90034-0

[3]   Agardh, C.D., Bjorgell, P. and Nilsson-Ehle, P. (1999) The effects of tolbutamide on lipoproteins, lipoprotein lipase and hormone-sensitive lipase. Diabetes Research and Clinical Practice, 46, 99-108. doi:10.1016/S0168-8227(99)00088-1

[4]   Dauchet, L., Amouyel, P., Hercberg, S. and Dallongeville, J. (2006) Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. Journal of Nutrition, 136, 2588-2593.

[5]   Sanz, M.L., del Castillo, M.D., Corzo, N. and Olano, A. (2000) Presence of 2-furoylmethyl derivatives in hydro-lysates of processed tomato products. Journal of Agri-cultural and Food Chemistry, 48, 468-471. doi:10.1021/jf990697b

[6]   Gorinstein, S., Leontowicz, H., Leontowicz, M., Drze-wiecki, J., Najman, K., Katrich, E., et al. (2006) Raw and boiled garlic enhances plasma antioxidant activity and improves plasma lipid metabolism in cholesterol-fed rats. Life Sciences, 78, 655-663. doi:10.1016/j.lfs.2005.05.069

[7]   Fagbemi, A.A., Torrente, F., Hilson, A.J., Thomson, M.A., Heuschkel, R.B. and Murch, S.H. (2007) Massive ga-strointestinal haemorrhage in isolated intestinal Henoch- Schonlein purpura with response to intravenous immu-noglobulin infusion. European Journal of Pediatrics, 166, 915-919. doi:10.1007/s00431-006-0337-3

[8]   Miranda-Vilela, A.L., Alves, P.C., Akimoto, A.K., Pereira, L.C., Nazare Klautau-Guimaraes, M.D. and Grisolia, C.K. (2010) The effect of hydrogen peroxide-induced oxidative stress on leukocytes depends on age and physical training in healthy human subjects carrying the same genotypes of antioxidant enzymes’ gene polymorphisms. American Journal of Human Biology, 22, 807- 812. doi:10.1002/ajhb.21086

[9]   Utesch, D., Feige, K., Dasenbrock, J., Broschard, T.H., Harwood, M., Danielewska-Nikiel, B., et al. (2008) Evaluation of the potential in vivo genotoxicity of quer-cetin. Mutation Research, 654, 38-44.

[10]   Omar, S.H., Radwan, K.G., Youssif, M.A., Khafagy, H.F., Kamal, N.M., El-Sabae, H.H., et al. (2009) A non-opioid fast track anesthetic regimen for colonic resection. Journal of the Egyptian Society of Parasitologyl, 39, 849-864.

[11]   Eidi, A., Eidi, M. and Esmaeili, E. (2006) Antidiabetic effect of garlic (Allium sativum L.) in normal and strep-tozotocin-induced diabetic rats. Phytomedicine, 13, 624-629. doi:10.1016/j.phymed.2005.09.010

[12]   Chang, M.L. and Johnson, M.A. (1980) Effect of garlic on carbohydrate metabolism and lipid synthesis in rats. Journal of Nutrition, 110, 931-936.

[13]   Kojuri, J., Vosoughi, A.R. and Akrami, M. (2007) Effects of anethum graveolens and garlic on lipid profile in hyperlipidemic patients. Lipids in Health and Disease, 6, 5. doi:10.1186/1476-511X-6-5

[14]   Butt, M.S., Sultan, M.T., Butt, M.S. and Iqbal, J. (2009) Garlic: nature’s protection against physiological threats. Critical Reviews in Food Science and Nutrition, 49, 538-551. doi:10.1080/10408390802145344

[15]   Asdaq, S.M., Inamdar, M.N. and Asad, M. (2009) Effect of conventional antihypertensive drugs on hypolipidemic action of garlic in rats. Indian Journal of Experimental Biology, 47, 176-181.

[16]   Mahmoodi, M., Islami, M.R., Asadi Karam, G.R., Khak-sari, M., Sahebghadam Lotfi, A., Hajizadeh, M.R., et al. (2006) Study of the effects of raw garlic consumption on the level of lipids and other blood biochemical factors in hyperlipidemic individuals. Pakistan Journal of Phar-maceutical Sciences, 19, 295-298.

[17]   Villar-Palasi, C. and Larner, J. (1961) Insulin treatment and increased UDPG-glycogen transglucosylase activity in muscle. Archives of Biochemistry and Biophysics, 94, 436-442. doi:10.1016/0003-9861(61)90071-6

[18]   Kannar, D., Wattanapenpaiboon, N., Savige, G.S. and Wahlqvist, M.L. (2001) Hypocholesterolemic effect of an enteric-coated garlic supplement. Journal of the American College of Nutrition, 20, 225-231.

[19]   Morcos, N.C. (1997) Modulation of lipid profile by fish oil and garlic combination. Journal of the National Med-ical Association, 89, 673-678.

[20]   Superko, H.R. and Krauss, R.M. (2000) Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein (a). Journal of the American College of Cardiology, 35, 321-326. doi:10.1016/S0735-1097(99)90541-7

[21]   Ahmed, R.S. and Sharma, S.B. (1997)Biochemical studies on combined effects of garlic (Allium sativum Linn) and ginger (Zingiber officinale Rosc) in albino rats. Indian Journal of Experimental Biology, 35, 841-843.

[22]   Chaudhuri, B.N., Mukherjee, S.K., Mongia, S.S. and Chakravarty, S.K. (1984) Hypolipidemic effect of garlic and thyroid function. Biomedica Biochimica Acta, 43, 1045-1047.

[23]   Oi, Y., Imafuku, M., Shishido, C., Kominato, Y., Nishi-mura, S. and Iwai, K. (2001) Garlic supplementation in-creases testicular testosterone and decreases plasma cor-ticosterone in rats fed a high protein diet. Journal of Nu-trition, 131, 2150-156.

[24]   Eriksson, J. and Kohvakka, A. (1995) Magnesium and ascorbic acid supplementation in diabetes mellitus. Annals of Nutrition and Metabolism, 39, 217-223. doi:10.1159/000177865

[25]   Singh, A and Shukla, Y. (1998) Antitumor activity of diallyl sulfide in two-stage mouse skin model of carci-nogenesis. Biomedical and Environmental Sciences, 11, 258-263.