The Effect of Gold Nanoparticle on Absorbed Dose by IMRT in Esophagus Phantom
Author(s)
Zeinabnamazi Shiraazi1,
Seyedrabie Mahdavi2,
Mohammad Mahdavi1,
Mahboubeh Khadem Abolfazli3*
Affiliation(s)
1 Physics Department, Mazandaran University, Babolsar, Iran. 2 Medical Physics Department, Iran University of Medical Science, Tehran, Iran. 3 Radiation Department, Babol University of Medical Science, Babol, Iran.
1 Physics Department, Mazandaran University, Babolsar, Iran. 2 Medical Physics Department, Iran University of Medical Science, Tehran, Iran. 3 Radiation Department, Babol University of Medical Science, Babol, Iran.
ABSTRACT
This study aimed to evaluate the use of dosimeters MAGICA gel impregnated
with nanoparticles of gold to increase the dose of faulty tissue in the chest
phantom in the esophagus and other organs to determine the dose and dose
distribution in the tissue with an IMRT treatment. In this study, based on
previous studies, the optimal concentration of 0.1 mM gold nanoparticles has
been considered. Also, better localization and avoid radiation received dose by
other organizations around the IMRT machine used for radiation. For comparison
and understanding of dose distribution and dose rate increase factor (DEF), gel
dosimeters were acquired by MRI. The results showed that by adding gold
nanoparticles with a diameter of 50 nm and optimum concentration is 0.1 mM, the
dose and energy 500 cGy and 6 MV with IMRT respectively, the factors increasing
the dose (DEF) is about 9.74%. It’s remarkable, this research is that Esophagus
phantom to containing gold nanoparticles to other tissues (lung and spinal
cord) and also the Phantom of the esophagus in the absence of gold
nanoparticles, has received the highest dose and compared with the non-nano R2 Increased. It is also a good match between the results of dosimetry gel and
results of treatment.
Cite this paper
Shiraazi, Z. , Mahdavi, S. , Mahdavi, M. and Abolfazli, M. (2015) The Effect of Gold Nanoparticle on Absorbed Dose by IMRT in Esophagus Phantom. Open Access Library Journal, 2, 1-10. doi: 10.4236/oalib.1101919.
Shiraazi, Z. , Mahdavi, S. , Mahdavi, M. and Abolfazli, M. (2015) The Effect of Gold Nanoparticle on Absorbed Dose by IMRT in Esophagus Phantom. Open Access Library Journal, 2, 1-10. doi: 10.4236/oalib.1101919.
References
[1] Letsinger, R.L., Mirkin, C.A., Elghanian, R., Mucic, R.C. and Storhoff, J.J. (1999) Chemistry of Oligonucleotide-Gold Nanoparticle Conjugates. Phosphorus, Sulfur and Silicon and the Related Elements, 144, 359-362.
http://dx.doi.org/10.1080/10426509908546255 [2] Maeda, H., Seymour, L.W. and Miyamoto, Y. (1992) Conjugates of Anticancsr Agents and Polymers-Advantages of Macromolecular Therapeutics in Vivo. Bioconjugate Chemistry, 3, 351-362.
http://dx.doi.org/10.1021/bc00017a001 [3] Qi, X.R., Maitani, Y., Nagai, T. and Wei, S.L. (1997) Comparative Pharmacokinetics and Antitumor Efficacy of Doxorubicin Encapsulated in Soybean-Derived Sterols and Poly (Ethylene Glycol) Liposomes in Mice. International Journal of Pharmaceutics, 146, 31-39.
http://dx.doi.org/10.1016/S0378-5173(96)04753-9 [4] Connor, E.E., Mwamuka, J., Gole, A., Murphy, C.J. and Wyatt, M.D. (2005) Gold Nanoparticles Are Taken up by Human Cells but Do Not Cause Cytotoxicity. Small, 1, 325-327.
http://dx.doi.org/10.1002/smll.200400093 [5] Fong, P.M., Kiel, D.Z., Does, M.D. and Core, J.C. (2001) Polymer Gels for Magnetic Resonance Imaging of Radiation Dose Distributions at Normal Room Atmosphere. Physics in Medicine and Biology, 46, 3105-3113.
http://dx.doi.org/10.1088/0031-9155/46/12/303 [6] Khadem Abolfazli, M., Mahdavi, M., Mahdavi, S.R.M. and Ataei, Gh. (2013) Dose Enhancement Effect of Gold Nanoparticles on MAGICA Polymer Gel in Mega Voltage Radiation Therapy. International Journal of Radiation Research, 11, 55-61. [7] Mahdavi, M., Khadem Abolfazli, M., Mahdavi, S.R.M. and Ataei, Gh. (2013) Effect of Gold Nanoparticle on Percentage Depth Dose Enhancement on Megavoltage Energy in MAGICA Polymer Gel Dosimeter. Journal of Biomedical Physics and Engineering, 3, 37-44. [8] Atae, Gh., Mahdavi, S.R., Mohammadi Nokhandani, A., Taheri Otaghsara, M. and Khadem Abolfazli, M. (2015) Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter. International Journal of Biomedical Science and Engineering, 3, 1-4.
http://dx.doi.org/10.11648/j.ijbse.20150301.11
[1] Letsinger, R.L., Mirkin, C.A., Elghanian, R., Mucic, R.C. and Storhoff, J.J. (1999) Chemistry of Oligonucleotide-Gold Nanoparticle Conjugates. Phosphorus, Sulfur and Silicon and the Related Elements, 144, 359-362.
http://dx.doi.org/10.1080/10426509908546255 [2] Maeda, H., Seymour, L.W. and Miyamoto, Y. (1992) Conjugates of Anticancsr Agents and Polymers-Advantages of Macromolecular Therapeutics in Vivo. Bioconjugate Chemistry, 3, 351-362.
http://dx.doi.org/10.1021/bc00017a001 [3] Qi, X.R., Maitani, Y., Nagai, T. and Wei, S.L. (1997) Comparative Pharmacokinetics and Antitumor Efficacy of Doxorubicin Encapsulated in Soybean-Derived Sterols and Poly (Ethylene Glycol) Liposomes in Mice. International Journal of Pharmaceutics, 146, 31-39.
http://dx.doi.org/10.1016/S0378-5173(96)04753-9 [4] Connor, E.E., Mwamuka, J., Gole, A., Murphy, C.J. and Wyatt, M.D. (2005) Gold Nanoparticles Are Taken up by Human Cells but Do Not Cause Cytotoxicity. Small, 1, 325-327.
http://dx.doi.org/10.1002/smll.200400093 [5] Fong, P.M., Kiel, D.Z., Does, M.D. and Core, J.C. (2001) Polymer Gels for Magnetic Resonance Imaging of Radiation Dose Distributions at Normal Room Atmosphere. Physics in Medicine and Biology, 46, 3105-3113.
http://dx.doi.org/10.1088/0031-9155/46/12/303 [6] Khadem Abolfazli, M., Mahdavi, M., Mahdavi, S.R.M. and Ataei, Gh. (2013) Dose Enhancement Effect of Gold Nanoparticles on MAGICA Polymer Gel in Mega Voltage Radiation Therapy. International Journal of Radiation Research, 11, 55-61. [7] Mahdavi, M., Khadem Abolfazli, M., Mahdavi, S.R.M. and Ataei, Gh. (2013) Effect of Gold Nanoparticle on Percentage Depth Dose Enhancement on Megavoltage Energy in MAGICA Polymer Gel Dosimeter. Journal of Biomedical Physics and Engineering, 3, 37-44. [8] Atae, Gh., Mahdavi, S.R., Mohammadi Nokhandani, A., Taheri Otaghsara, M. and Khadem Abolfazli, M. (2015) Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter. International Journal of Biomedical Science and Engineering, 3, 1-4.
http://dx.doi.org/10.11648/j.ijbse.20150301.11