JBiSE  Vol.9 No.8 , July 2016
The Impact of Age and Duration of Cochlear Implant in a Congenital Deaf Population: An ERP Study
Abstract: Objective: It is well known that patients with Cochlear Implant (CI) have a large inter-individual variability in linguistic and auditory performances. This can be related to individual auditory processing abilities and integrity of auditory system from auditory nerve to cerebral cortex. P300 can be used for the evaluation of central auditory functions in people with hearing loss and CI. No studies considered the P300 in the population of prelingually deafened adults that underwent CI in old age. The aim of this study is to assess Event Related Potential (ERP) in patients with congenital profound hearing loss with early or late implantation and evaluate these results respect to an age-matched normal hearing group. Methods: ERPs (N100, N200 and P300) and auditory benefit testing (pure tone average and speech audiometric test) and auditory perception testing (Categories of Auditory Performance—CAP) were evaluated in all subjects with their device. Results: All mean latencies (N100, N200 and P300) were found greater in patients group compared to control group. When analyzing all measures in patient group, we did not find any significant differences according to age of implant while significant difference (p > 0.05) in N100 amplitude (p = 0.045) and P300 latency (p = 0.035) were found according to time of CI use. A linear correlation between N200 and P300 latency in control and patients groups was found. Conclusion: In summary, ERPs analysis in the evaluation of CI showed a great importance of long use of the device in addiction to an early time of implant.
Cite this paper: Ghiselli, S. , Gheller, F. , Trevisi, P. , Rampazzo, P. , Ermani, M. and Martini, A. (2016) The Impact of Age and Duration of Cochlear Implant in a Congenital Deaf Population: An ERP Study. Journal of Biomedical Science and Engineering, 9, 384-392. doi: 10.4236/jbise.2016.98033.

[1]   Gates, G.A. and Miyamoto, R.T. (2003) Cochlear Implants. The New England Journal of Medicine, 349, 421-423.

[2]   Kral, A. and O’Donoghue, G.M. (2010) Profound Deafness in Childhood. The New England Journal of Medicine, 363, 1438-1450.

[3]   Martini, A., Bovo, R., Trevisi, P., Forli, F. and Berrettini, S. (2013) Cochlear Implant in Children: Rational, Indications and Cost/Efficacy. Minerva Pediatrica, 65, 325-339

[4]   Ramsden, R. and Graham, J. (1995) Cochlear Implantation. BMJ, 311, 1588.

[5]   Ponton, C.W., Don, M., Eggermont, J.J., Waring, M.D., Kwong, B. and Masuda, A. (1996) Auditory System Plasticity in Children after Long Periods of Complete Deafness. NeuroReport, 8, 61-65.

[6]   Sharma, A., Dorman, M.F. and Spahr, A.J. (2002) A Sensitive Period for the Development of the Central Auditory System in Children with Cochlear Implants: Implication for Age of Implantation. Ear and Hearing, 23, 532-539.

[7]   Polich, J. and Herbst, K.L. (2000) P300 as a Clinical Assay: Rationale, Evaluation, and Findings. International Journal of Psychophysiology, 38, 3-19.

[8]   Reis, A.C.M., Frizzo, A.C., Isaac,, Garcia, C.F., Funayama, C.A. and Iório, M.C. (2015) P300 in Individuals with Sensorineural Hearing Loss. Brazilian Journal of Otorhinolaryngology, 81, 126-132.

[9]   Martin, B.A., Tremblay, K.L. and Korczak, P. (2008) Speech Evoked Potentials: From the Laboratory to the Clinic. Ear and Hearing, 29, 285-313.

[10]   Polen, S.B. (1984) Auditory Event Related Potentials. Seminars in Hearing, 5, 127-141.

[11]   Oates, P.A., Kurtzberg, D. and Stapells, D.R. (2002) Effects of Sensorineural Hearing Loss on Cortical Event-Related Potential and Behavioral Measures of Speech-Sound Processing. Ear and Hearing, 23, 399-415.

[12]   Oviatt, D.L. and Kileny, P.R. (1991) Auditory Event-Related Potentials Elicited from Cochlear Implant Recipients and Hearing Subjects. American Journal of Audiology, 1, 48-55.

[13]   Kelly, A.S., Purdy, S.C. and Thorne, P.R. (2005) Electrophysiological and Speech Perception Measures of Auditory Processing in Experienced Adult Cochlear Implant Users. Clinical Neurophysiology, 116, 1235-1246.

[14]   Henkin, Y., Tetin-Schneider, S., Hildesheimer, M. and Kishon-Rabin, L. (2009) Cortical Neural Activity Underlying Speech Perception in Postlingual Adult Cochlear Implant Recipients. Audiology and Neurotology, 14, 39-53.

[15]   Obuchi, C., Harashima, T. and Shiroma, M. (2012) Auditory Evoked Potentials under Active and Passive Hearing Conditions in Adult Cochlear Implant Users. Clinical and Ex-perimental Otorhinolaryngology, 5, S6-S9.

[16]   Micco, A.G., Kraus, N., Koch, D.B., McGee, T.J., Carrell, T.D., Sharma, A., Nicol, T. and Wiet, RJ. (1995) Speech-Evoked Cognitive P300 Potentials in Cochlear Implant Recipients. American Journal of Otolaryngology, 16, 514-520.

[17]   Soshi, T., Hisanaga, S., Kodama, N., Kanekama, Y., Samejima, Y., Yumoto, E. and Sekiyama, K. (2014) Event-Related Potentials for Better Speech Perception in Noise by Cochlear Implant Users. Hearing Research, 316, 110-121.

[18]   Beynon, A.J. and Snik, A.F. (2004) Use of the Event-Related P300 Potential in Cochlear Implant Subjects for the Study of Strategy-Dependent Speech Processing. Internation Journal of Audiology, l43, S44-S47.

[19]   Kileny, P.R., Boerst, A. and Zwolan, T. (1997) Cognitive Evoked Potentials to Speech and Tonal Stimuli in Children with Implants. Otolaryngology—Head and Neck Surgery, 117, 161-169.

[20]   Henkin, Y., Kileny, P.R., Hildesheimer, M. and Kishon-Rabin, L. (2008) Phonetic Processing in Children with Cochlear Implants: An Auditory Event-Related Potentials Study. Ear and Hearing, 29, 239-249.

[21]   Cutugno, F., Prosser, S. and Turrini, M. (2000) Audiometria Vocale. GN. ReSound, Itay.

[22]   Archbold, S. (1994) Monitoring Progress in Children at the preverbal Stage. Cochlear Implants for Young Children. Whurr, London.