ABSTRACT We present the case of a young male who visited the emergency room with progressive dys pnea and left sided chest pain. A chest X-ray was performed which showed a pattern of diffuse nodular and reticular opacities. The diagnosis of Necrotizing Sarcoid Granulomatosis (NSG) was made by histopathological examination of a lung biopsy specimen and by exclud ing other causes of granulomatous disease. He was treated with corticosteroids. Because of persistent extrapulmonary (ocular) involvement a maintenance dose of prednisone was needed. Necrotizing Sarcoid Granulomatosis is a granulomatous disease with necrosis and vasculitis of unknown cause. The resemblance between NSG and (nodular) sarcoidosis is strong, but subtle differences exist. The prognosis is good and therapy is usually not necessary. However in some cases there is a need for therapy with corticosteroids, depending on the involved organs and/or the degree of impairment.
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nullEpping, G. , Schwengle, C. , Aliredjo, R. and Wagenaar, M. (2011) Necrotizing sarcoid granulomatosis: a case report and review of progresses in this disease. Health, 3, 534-536. doi: 10.4236/health.2011.38089.
 Liebow, A.A. (1973) The J. burns amberson lecture. Pulmonary angiitis and granulomatosis. American Review of Respiratory Disease, 108, 1-18.
Churg, A., Carrington, C.B. and Gupta, R. (1979) Necrotizing sarcoid granulomatosis. Chest, 76, 406-413.
Churg, A. (1983) Pulmonary angiitis and granulomatosis revisited. Human Pathology, 14, 868-883.
Quaden, C., Tillie-Leblond, I., Delobbe, A., et al. (2005) Necrotising sarcoid granulomatosis: Clinical, functional, endoscopical and radiographical evaluations. European Respiratory Journal, 26, 778-785.
Rosen, Y. (2007) Pathology of sarcoidosis. Seminars in Respiratory and Critical Care Medicine, 28, 36-51.
Popper, H.H., Klemen, H., Colby, T.V. and Churg, A. (2003) Necrotizing sarcoid granulomatosis—Is it different from nodular sarcoidosis? Pneumologie, 57, 268-271.
Koss, M.N., Hochholzer, L., Feigin, D.S., Garancis, J.C. and Ward, P.A. (1980) Necrotizing sarcoid-like granulomatosis: clinical, pathologic, and immunopathologic findings. Human Pathology, 11, 510-519.
Alberti, S., Falleni, M., Tarsia, P., et al. (2006) A 13-year-old female with shortness of breath and pleuritic chest pain. European Respiratory Journal, 28, 876-882.
Chittock, D.R., Joseph, M.G., Paterson, N.A.M. and McFadden, R.G. (1994) Necrotizing sarcoid granulomatosis with pleural involvement: Clinical and radiographic features. Chest, 106, 672-676.
Dykhuizen, R.S., Smith, C.C., Kennedy, M.M., et al. (1997) Necrotizing sarcoid granulomatosis with extrapulmonary involvement. European Respiratory Journal, 10, 245-247. doi:10.1183/09031936.97.10010245
Strickland-Marmol, L.B., Fessler, R.G. and Rojiani, A.M. (2000) Necrotizing sarcoid granulomatosis mimicking an intracranial neoplasm: Clinicopathologic features and review of the literature. Modern Pathology, 13, 909-913.
Lynch III, J.P., Kazerooni, E.A. and Gay, S.E. (1997) Pulmonary sarcoidosis. Clinics In Chest Medicine, 18, 755-785. doi:10.1016/S0272-5231(05)70417-2