OJI  Vol.6 No.2 , June 2016
Isoforskolin from Native Plant Coleus forskohlii of Yunnan, China Plays Multiple Biological Roles
Abstract: Isoforskolin (ISOF) was isolated from Coleus forskohlii native to Yunnan in China. It is identified as one analog of diterpene forskolin (FSK) which comes from the Indian plant Coleus forskohlii. Researches found that the Yunnan native plant Coleus forskohlii contained rich ISOF but not FSK. ISOF was reported to activate adenylyl cyclase (AC) isoforms. The ophthalmologic and cardiovascular effects of ISOF were firstly reported in the 1990s. The researchers in Kunming, China, found ISOF could lower blood pressure and intraocular pressure. Recent researches found the respiratory tract effects of ISOF, and showed that ISOF significantly elevated cyclic adenosine monophosphate (cAMP) levels in rat lung homogenate, and relaxed the histamine-induced contraction of isolated guinea pig trachea and lung smooth muscle, isoforskolin pretreatment attenuates acute lung injury induced by lipopolysaccharide (LPS) in several models, lowered LPS-induced secretion of the inflammatory cytokine in human monocytes.
Cite this paper: Feng, S. , Wang, L. , P. Voravuthikunchai, S. , Liang, Z. , Liu, A. and Bao, F. (2016) Isoforskolin from Native Plant Coleus forskohlii of Yunnan, China Plays Multiple Biological Roles. Open Journal of Immunology, 6, 63-66. doi: 10.4236/oji.2016.62006.

[1]   World Health Organization (2013) Global Review of T&CM. In WHO Traditional Medicine Strategy: 2014-2023, WHO Press, 20 Avenue Appia, 1211 Geneva 27, Switzerland, 25-26.

[2]   Yang, S.T. and Gao, F. (2007) Pharmacognostical Studies on Coleus forskohlii Briq. Yunnan University of Traditional Chinese Medicine, 30, 8-10.

[3]   Xu, L.L. and Kong, L.Y. (2006) Labdane Diterpenoids from Coleus forskohlii (Wild) Briq. Journal of Integrative Plant Biology, 48, 478-481.

[4]   Alasbahi, R.H. and Melzig, M.F. (2012) Forskolin and Derivatives as Tools for Studying the Role of cAMP. Pharmazie, 67, 5-13.

[5]   Nie, L.H., Li, X.H., Chen, Z.H., Wang, X.H. and Wang, D.C. (1999) Suppressing Effects of Isoforskolin Administered Topically on Intraocular Pressure in Conscious Rabbits. Chinese Ophthalmology Research, 17, 90-92.

[6]   Li, X.H., Nie, L.H., Yang, W.M., Chen, Z.H., Wang, X.H. and Luo, L.H. (2000) Suppressing Effect of Isoforskolin and Forskolin on Ocular Hypertension in Rabbits. Chinese Journal of Ophthalmology, 36, 292-294.

[7]   Yang, W.M., Li, X.H., Chen, Z.H., Nie, L.H., Wang, B.L. and Shen, Z.Q. (2001) Adenylate Cyclase Stimulation and Ocular Hypertension Inhibition by Forskolin Analogs. Chinese Ophthalmology Research, 19, 1-4.

[8]   Yang, W.M., Li, X.H., Chen, Z.H., Nie, L.H., Li, L. and Lei, W.Y. (2001) Effects of Two Forskolin Analogs on the Elevation of Ocular Pressure in Human. Chinese Journal of Ophthalmology, 19, 556-559.

[9]   Ma, G.Y., Chen, Z.H. and Wang, D.C. (1994) The Inhibitory Effects of Isoforskolin on Rat and Guinea Pig Platelet Aggregation in the Whole Blood. Journal of Kunming Medical University, 15, 18-21.

[10]   Chen, B.Y., Lei, X.L., Wang, X.H., Chen, Z.H. and Wang, D.C. (1994) The Effects of 1-Acetylforskolin and Isoforskolin on the Hemodynamics in Rats. Journal of Kunming Medical University, 15, 53-55.

[11]   Zhao, J.S., Yang, W.M., Yang, Z.B., Li, J.X. and Fu, J.J. (2014) Study on General Pharmacology of Forskolin and Isoforskolin. Journal of Kunming Medical University, 35, 37-40.

[12]   Pei, X.N., Qing, C., Chen, G.Z., Xu, Y.L., Jin, Q.D., Ma, L.M. and Yang, W.M. (2008) Effects of Active Ingredients from Coleus forskohlii on Human Neutrophil. Chinese Journal of Emergency Medicine, 17, 1266-1270.

[13]   Yang, W.M., Qiang, D.Q., Zhang, M., Ma, L.M., Zhang, Y.H., Qing, C., Xu, Y.L., Zhen, C.L., Liu, J.K. and Chen, Y.H. (2011) Isoforskolin Pretreatment Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Animal Models. International Immunopharmacology, 11, 683-692.

[14]   Wang, Y.Q., Cao, S.J., Yin, J.J., Huang, J.M. and Weng, H.B. (2013) Relaxation Effects of Forskolin Analogues on Isolated Bronchioles in Guinea Pig. Chinese Pharmacological Bulletin, 29, 714-717.

[15]   Shan, Y.S., Xu, L.L, Lu, Y., Wang, X.B., Zheng, Q.T., Kong, L.Y. and Niwa, M. (2008) Diterpenes from Coleus forskohlii (Wild) Briq. (Labiatae). Chinese Pharmacological Bulletin, 56, 52-56.

[16]   Khatun, S., Chatterjee, N.C. and Cakilcioglu, U. (2011) Antioxidant Activity of the Medicinal Plant Coleus forskohlii Briq. African Journal of Biotechnology, 10, 2530-2535.

[17]   Paul, M., Radha, A. and Kumar, D.S. (2013) On the High Value Medicinal Plant, Coleus forskohlii Briq. Hygeia Journal for Drugs & Medicines, 5, 69-78.