JBiSE  Vol.9 No.6 , May 2016
Diabetes Developing Diagram
Abstract: Diabetes mellitus is a metabolic disorder that the cells cannot uptake and use glucose as a source of energy. Many dysfunctions in mitochondria biogenesis/activity and some glycolysis enzymes in diabetic patients have been reported. The aim of this mini-review is to elucidate the cross-talk between signaling pathway which involved in developing of diabetes. Here, there are a related, documented reasons and evidences which investigate energy deficiency in this disease. It seems that a cascade of signaling such as transcription factors (MEF2, CREB, NFAT, P38, MAPK, AMPK) co-activators (PGC-1α) such as calcium ion, protein dependent calcium(CAMK, calcineurine) and Na+-K+ pump have a main role in cell energy regulation. Any dysfunction in these factors can develop diabetes and here, Na+-K+ pump is known as a start point of this diagram.
Cite this paper: Bakhtiari, N. (2016) Diabetes Developing Diagram. Journal of Biomedical Science and Engineering, 9, 298-301. doi: 10.4236/jbise.2016.96023.

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