A Rare Cause of Precocious Puberty and Massive Ovarian Cysts Associated with Hypothyroidism

Nabil  Moatassim Billah; Hajar  El Kouarty; Rachida  Dafiri

doi:10.4236/ojcd.2016.61001

Nabil Moatassim Billah^*, Hajar El Kouarty, Rachida Dafiri

Abstract: Van Wyk-Grumbach syndrome (VWGS) is characterized by juvenile hypothyroidism, delayed bone age, isosexual precocious puberty and massive ovarian cysts. We report such a case in a 7-year-old girl who presented with a bilateral pelvic pain, abdominal distension and signs of hypothyroidism. Physical examination showed a breast development and lack of pubic and axillary hair. There was no clitoromegaly. Pelvic ultrasonography and CT scan showed enlarged bilateral multiloculared multicystics ovarian masses. The pituitary MRI was recommended before an elevated prolactin, revealed a large sellar and suprasellar mass. The patient was started on thyroid replacement using L-Thyroxine. Clinically, the patient’s fatigue, pelvic pain, and abdominal distension are resolved. During the follow-up, her thyroid functions and serum prolactin normalized within 8 months. Ultrasonography revealed regression of ovarian cysts in 2 months measuring, with normal sized ovaries in 14 months.

Keywords: Van Wyk-Grumbach, Precocious Puberty, Hypothyroidism, Ovarian Cysts

Cite this paper: Moatassim Billah, N. , El Kouarty, H. and Dafiri, R. (2016) A Rare Cause of Precocious Puberty and Massive Ovarian Cysts Associated with Hypothyroidism. Open Journal of Clinical Diagnostics, 6, 1-5. doi: 10.4236/ojcd.2016.61001.

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