Hongyan Jin¹, Xiaoya Chen², Wei He¹, Qian Liu¹, Zexiong Wei¹, Jinjun Li^2*

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¹ Department of Oncology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
² Medical College of Wuhan University of Science and Technology, Wuhan, China.
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Abstract: Objective: This analysis was conducted to clarify risk factors for chemotherapy-induced leukopenia (CIL) in lung cancer. Methods: A retrospective study was conducted on data from 358 patients with lung cancer who received chemotherapy. Results: Among 358 cases of lung cancer who received chemotherapy, a total of 240 patients experienced CIL, rate was 67%. The demographic data including gender (P = 0.795), age (P = 0.134), presence of selected chronic comorbidities (P = 0.23) were not significantly different in the two groups. The weight loss rate, PS score, sub-normal pre-WBC level, sub-normal pre-PLT level, and the cycle of chemotherapy were significantly different between the groups (P < 0.05). Multivariate analysis revealed that the weight loss rate ≥5% (OR = 0.503), sub-normal pre-WBC level (OR = 11.807), the cycle of chemotherapy ≥3 (OR = 3.100) were main risk factors for CIL in lung cancer. Conclusion: Before treatment, weight loss rate is 5% or higher, chemotherapy has a cycle of 3 or more and sub-normal WBC level is independent risk factor of lung cancer after chemotherapy-induced leucopenia.

Keywords: Chemotherapy-Induced Leucopenia, Risk Factors, Lung Cancer

Cite this paper: Jin, H. , Chen, X. , He, W. , Liu, Q. , Wei, Z. and Li, J. (2016) Risk Factors for Chemotherapy-Induced Leukopenia in Patients with Lung Cancer. International Journal of Clinical Medicine, 7, 225-230. doi: 10.4236/ijcm.2016.73023.

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