IJCM  Vol.7 No.3 , March 2016
Risk Factors for Chemotherapy-Induced Leukopenia in Patients with Lung Cancer
Abstract: Objective: This analysis was conducted to clarify risk factors for chemotherapy-induced leukopenia (CIL) in lung cancer. Methods: A retrospective study was conducted on data from 358 patients with lung cancer who received chemotherapy. Results: Among 358 cases of lung cancer who received chemotherapy, a total of 240 patients experienced CIL, rate was 67%. The demographic data including gender (P = 0.795), age (P = 0.134), presence of selected chronic comorbidities (P = 0.23) were not significantly different in the two groups. The weight loss rate, PS score, sub-normal pre-WBC level, sub-normal pre-PLT level, and the cycle of chemotherapy were significantly different between the groups (P < 0.05). Multivariate analysis revealed that the weight loss rate ≥5% (OR = 0.503), sub-normal pre-WBC level (OR = 11.807), the cycle of chemotherapy ≥3 (OR = 3.100) were main risk factors for CIL in lung cancer. Conclusion: Before treatment, weight loss rate is 5% or higher, chemotherapy has a cycle of 3 or more and sub-normal WBC level is independent risk factor of lung cancer after chemotherapy-induced leucopenia.
Cite this paper: Jin, H. , Chen, X. , He, W. , Liu, Q. , Wei, Z. and Li, J. (2016) Risk Factors for Chemotherapy-Induced Leukopenia in Patients with Lung Cancer. International Journal of Clinical Medicine, 7, 225-230. doi: 10.4236/ijcm.2016.73023.

[1]   Ridge, C.A., McErlean, A.M. and Ginsberg, M.S. (2013) Epidemiology of Lung Cancer. Seminars in Interventional Radiology, 30, 93-98.

[2]   Liu, W., Zhang, C.C. and Li, K. (2013) Prognostic Value of Chemotherapy-Induced Leukopenia in Small-Cell Lung Cancer. Cancer Biology & Medicine, 10, 92-98.

[3]   Shitara, K., Matsuo, K., Oze, I., et al. (2011) Meta-Analysis of Neutropenia or Leukopenia as a Prognostic Factor in Patients with Malignant Disease Undergoing Chemotherapy. Cancer Chemotherapy and Pharmacology, 68, 301-307.

[4]   Han, Y.F., Gong, Z., Huang, L.Q., Xia, X. and Zhao, W.J. (2010) Clinical Study on Acupuncture for Leukopenia induced by Chemotherapy. Zhongguo Zhen Jiu, 30, 802-805.

[5]   Campos, M.I., Vieira, W.D., Campos, C.N., Aarestrup, F.M. and Aarestrup, B.J. (2015) Atorvastatin and Trans-Caryophyllene for the Prevention of Leukopenia in an Experimental Chemotherapy Model in Wistar Rats. Molecular and Clinical Oncology, 3, 825-828.

[6]   Choi, T.Y., Lee, M.S. and Ernst, E. (2015) Moxibustion for the Treatment of Chemotherapy-Induced Leukopenia: A Systematic Review of Randomized Clinical Trials. Support Care Cancer, 23, 1819-1826.

[7]   Karaca, H., Bozkurt, O., Ozaslan, E., et al. (2014) Positive Effects of Oral Beta-Glucan on Mucositis and Leukopenia in Colorectal Cancer Patients Receiving Adjuvant FOLFOX-4 Combination Chemotherapy. Asian Pacific Journal of Cancer Prevention, 15, 3641-3644.

[8]   Li, J., Dai, C.H., Shi, S.B., Bao, Q.L., Yu, L.C. and Wu, J.R. (2010) Induction Concurrent Chemoradiotherapy Compared with Induction Radiotherapy for Superior Sulcus Non-Small Cell Lung Cancer: A Retrospective Study. Asia-Pacific Journal of Clinical Oncology, 6, 57-65.

[9]   Khafagy, R., Shackley, D., Samuel, J., O’Flynn, K., Betts, C. and Clarke, N. (2007) Complications Arising in the Final Year of Life in Men Dying from Advanced Prostate Cancer. Journal of Palliative Medicine, 10, 705-711.

[10]   Su, Z., Mao, Y.P., OuYang, P.Y., Tang, J., Lan, X.W. and Xie, F.Y. (2015) Leucopenia and Treatment Efficacy in Advanced Nasopharyngeal Carcinoma. BMC Cancer, 15, 429.

[11]   Tendas, A., Niscola, P., Perrotti, A., Dentamaro, T., de Fabritiis, P. and Arcese, W. (2015) Chemotherapy Induced Nausea and Vomiting in Bone Marrow Transplant: The Unmet Need. Support Care Cancer, 23, 2211.

[12]   Pais, I., Correia, N., Pimentel, I., et al. (2014) Effects of Acupuncture on Leucopenia, Neutropenia, NK, and B Cells in Cancer Patients: A Randomized Pilot Study. Evidence-Based Complementary and Alternative Medicine, 2014, Article ID: 217397.