JBM  Vol.4 No.3 , March 2016
2D Numerical Simulation of Liver Cell Proliferation with Angiogenesis for Hepatic Lobule Formation
ABSTRACT

The liver has the ability to reform and regenerate in our body. However, the mechanisms of reformation or regeneration of the liver have not been elucidated. In this study, we propose an analysis model using a Particle Model to elucidate the mechanism of liver formation. The object of analysis is a hepatic lobule, which is the basic component of the liver. First, a 2-dimensional cell proliferation around one blood vessel was modeled. Second, angiogenesis was added and considered. And finally, the model was applied to the hepatic lobule and the 2D formation of the hepatic lobule was revealed. We used experimentally derived parameters such as diffusivity, oxygen concentration, and oxygen consumption of a cell. The model will be expected to facilitate in developing tissue-engineered liver using regenerative medicine technology.


Cite this paper
Nagayama, K. , Tanaka, H. , Oshiumi, Y. , Shirakigawa, N. and Ijima, H. (2016) 2D Numerical Simulation of Liver Cell Proliferation with Angiogenesis for Hepatic Lobule Formation. Journal of Biosciences and Medicines, 4, 38-43. doi: 10.4236/jbm.2016.43007.
References
[1]   Shirakigawa, N., Ijima, H. and Takei, T. (2012) Decellularized Liver as a Practical Scaffold with a Vascular Network Template for Liver Tissue Engineering. Journal of Bioscience and Bioengineering, 114, 546-551. http://dx.doi.org/10.1016/j.jbiosc.2012.05.022

[2]   (2015) Science Daily. http://www.sciencedaily.com/releases/

[3]   Nagayama, K., Nitta, J. and Miura, I. (2009) Numerical Analysis on An-giogenesis in Cancer Using a Particle Model. Theoretical and Applied Mechanics Japan, 58, 321-324.

[4]   Nagayama, K., Matsuoka, S., Morisaki, N. and Taguchi, H. (2015) 3D Numerical Simulation of Hair Formation Process Using a Particle Model. Open Journal of Regenerative Medicine, 4, 1-5. http://file.scirp.org/Html/1-2390044_53849.htm http://dx.doi.org/10.4236/ojrm.2015.41001

[5]   Nagayama, K., Uehara, T., Amano, Y. and Tanahashi, M. (2015) 3D Numerical Simulation of Epidermal Skin Turnover Process Using a Particle Model.Journal of Biosciences and Medicines, 3, 45-49. http://dx.doi.org/10.4236/jbm.2015.33007

[6]   Hideo, O. (1982) Fluid Mechanics(1). Japan, Corona Publishing Co., Ltd., 118.

[7]   Ijima, H., et al. (1998) Hepatocyte Spheroids in Polyurethane Foams: Functional Analysis and Application for a Hybrid Artificial Liver. Tissue Eng., 4, 213-226. http://dx.doi.org/10.1089/ten.1998.4.213

[8]   Fanny, E., et al. (2010) Spontaneous Formation of Highly Functional Three-Dimensional Multilayer from Human Hepatoma Hep G2 Cells Cultured on an Oxygen-Permeable Polydimethylsiloxane Membrane. Tissue Eng., 16, 311-318. http://dx.doi.org/10.1089/ten.tec.2009.0042

 
 
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