The liver has the ability to reform and regenerate in our body. However, the mechanisms of reformation or regeneration of the liver have not been elucidated. In this study, we propose an analysis model using a Particle Model to elucidate the mechanism of liver formation. The object of analysis is a hepatic lobule, which is the basic component of the liver. First, a 2-dimensional cell proliferation around one blood vessel was modeled. Second, angiogenesis was added and considered. And finally, the model was applied to the hepatic lobule and the 2D formation of the hepatic lobule was revealed. We used experimentally derived parameters such as diffusivity, oxygen concentration, and oxygen consumption of a cell. The model will be expected to facilitate in developing tissue-engineered liver using regenerative medicine technology.
 Shirakigawa, N., Ijima, H. and Takei, T. (2012) Decellularized Liver as a Practical Scaffold with a Vascular Network Template for Liver Tissue Engineering. Journal of Bioscience and Bioengineering, 114, 546-551. http://dx.doi.org/10.1016/j.jbiosc.2012.05.022
 (2015) Science Daily. http://www.sciencedaily.com/releases/
 Nagayama, K., Matsuoka, S., Morisaki, N. and Taguchi, H. (2015) 3D Numerical Simulation of Hair Formation Process Using a Particle Model. Open Journal of Regenerative Medicine, 4, 1-5. http://file.scirp.org/Html/1-2390044_53849.htm http://dx.doi.org/10.4236/ojrm.2015.41001
 Nagayama, K., Uehara, T., Amano, Y. and Tanahashi, M. (2015) 3D Numerical Simulation of Epidermal Skin Turnover Process Using a Particle Model.Journal of Biosciences and Medicines, 3, 45-49. http://dx.doi.org/10.4236/jbm.2015.33007
 Ijima, H., et al. (1998) Hepatocyte Spheroids in Polyurethane Foams: Functional Analysis and Application for a Hybrid Artificial Liver. Tissue Eng., 4, 213-226. http://dx.doi.org/10.1089/ten.1998.4.213
 Fanny, E., et al. (2010) Spontaneous Formation of Highly Functional Three-Dimensional Multilayer from Human Hepatoma Hep G2 Cells Cultured on an Oxygen-Permeable Polydimethylsiloxane Membrane. Tissue Eng., 16, 311-318. http://dx.doi.org/10.1089/ten.tec.2009.0042