t selective pressure from the use of anti-microbial agents is a major determinant for the emergence of resistant strains [24] - [26] that could be considerable. Our results indicated that the rate of ciprofloxacin resistance pattern against P. aeruginosa was found to be relatively high percent in our population. Other studies show that ciprofloxacin resistance pattern was 23% in Spain [27] , 31.9% in Italy [28] and 26.8% in Latin America [29] . Overall results show that the rate of P. aeruginosa antibiotic resistance was observed in highest rate in case of Trimetoprime Solfametaxasole, while, Ciprofloxacin, Imipenem and Amikacin were identified as the most effective antibiotics in this study against P. aeruginosa. In previous studies it was reported that resistance to Imipenem was 14% in Spain [27] , 19.3% in Italy [28] and 68% in Saudi Arabia [30] that approved with our results. Previous studies show that antibacterial effects of Amikacin against pseudomonal were greater than Gentamycin [23] [31] and only 0.9% resistant reported to Amikacin in Turkey [23] . So, Amikacin is effective antibiotic against P. aeruginosa in their study. In current study, resistance pattern to Piperacillin was also higher, while Piperacillin resistance rate was 10% in Spain [27] , 12% in Italy [28] , 14% in Latin American population [29] . Indeed P. aeruginosa strains Infections, most be treated as soon as possible due to their severe resistance against antibiotics. We have to apply an accurate antibiotic treatment discipline, according to the findings based on antibiogram method in order to prevent its spread. Data showed that this bacterium has developed its resistance pattern against amikacin and Ciprofloxacin in comparison to previous years. So the use of effective infection control practices can go a long way to limiting the development and spread of antimicrobial resistance ensuring that these agents continue to find a place in treatment of P. aeruginosa infections and also, hospital infection monitoring committee needs to force the tasks of more severe monitoring on hospital pathogens and bacterial resistance pattern development studies as important objectives to finding effective antibiotics against P. aeruginosa.

NOTES

*Corresponding author.

Cite this paper
Rostamzadeh, Z. , Mohammadian, M. and Rostamzade, A. (2016) Investigation of Pseudomonas aeruginosa Resistance Pattern against Antibiotics in Clinical Samples from Iranian Educational Hospital. Advances in Microbiology, 6, 190-194. doi: 10.4236/aim.2016.63019.
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