Preparation and Characteristics of Film Dosage Form Natural Polysaccharides

Yoshifumi  Murata; Kyoko  Kofuji; Norihisa  Nishida; Ryosei  Kamaguchi

doi:10.4236/pp.2011.23028

Yoshifumi Murata^*, Kyoko Kofuji, Norihisa Nishida, Ryosei Kamaguchi

Abstract: We investigated preparation of film dosage form (FD) from natural polysaccharides using the casting method without organic solvents, heating or pH control. Ferulic acid (FA) and catechin were employed as model compounds incorporated in the FD, and the release profile of each compound from the form was investigated in the limited medium. Film formation was affected by the addition of the model compound to the polysaccharide solution. Rigid FD was obtained with 2% low-molecular-weight alginate (L-ALG; thickness, 65 µm), and it hardened after the addition of 0.5% polygalacturonic acid, although the thickness of the film did not change. The FDs immediately released the model compound, and the forms dissolved in phosphate-buffered saline. FD modification did not affect the FA release rate except in the early stage. FD would be a useful dosage form, especially for preventing or treating localized problems in the oral cavity.

Keywords: Film Dosage Form, Natural Polysaccharide, Sodium Alginate, Ferulic Acid, Catechin

Cite this paper: nullY. Murata, K. Kofuji, N. Nishida and R. Kamaguchi, "Preparation and Characteristics of Film Dosage Form Natural Polysaccharides," Pharmacology & Pharmacy, Vol. 2 No. 3, 2011, pp. 194-198. doi: 10.4236/pp.2011.23028.

References

[1] E.M. Hoffmann, A. Breitenbach and J. Breitkreutz, “Advances in orodispersible films for drug delivery,” Expert Opinion on Drug Delivery, Vol. 8, No. 3, 2011, pp. 299- 316.

[2] A. Nishida, M. Yamada, T. Kanazawa, Y. Takashima, K. Ouchi and H. Okada, “Sustained-release of protein from biodegradable sericin film, gel and sponge,” International Journal of Pharmaceutics, Vol. 407, 2011, pp. 44-52.

[3] S. Kunte and P. Tandale, “Fast dissolving strips: A novel approach for the drug delivery of verapamil,” Journal of Pharmacy and Bioallied Sciences, Vol. 2, No. 4, 2010, pp. 325-328.

[4] Y. Murata, T. Isobe, K. Kofuji, N. Nishida and R. Kama- guchi, “Preparation of fast dissolving films for oral dosage from natural polysaccharides,” Materials, Vol. 3, 2010, pp. 4291-4299.

[5] M. Nishimura, K. Matsuura, T. Tsukioka, H. Yamashita, N. Inagaki, T. Sugiyama and Y. Itoh, “In vitro and in vivo characteristics of prochlorperazine oral disintegration film,” International Journal of Pharmaceutics, Vol. 368, 2009, pp. 98-102.

[6] Y. Sakuda, A. Ito, M. Sasatsu and Y. Machida, “Preparation and evaluation of medical carbon oral films,” Chemical and Pharmaceutical Bulletin, Vol. 58, No. 4, 2010, pp. 454-457.

[7] M. F. Senyucel, M. B. Kologlu, R. Vargun, C, Akbay, F. N. Sarac, N. Renda, N. Hasirci, G. Gollu and H. Dindar, “The effect of local and sustained release of fibroblast growth factor on wound healing in esophageal anastomoses,” Journal of Pediatric Surgery, Vol. 43, 2008, pp. 290-295.

[8] K. C. Wood, J. Q. Boedicker D. M. Lynn and P. T. Hammond, “Tunable drug release from hydrolytically degradable layer-by-layer thin film,” Langmuir, Vol. 21, No. 4, 2005, pp. 1603-1609.

[9] P. Sriamornsak and R.A. Kennedy, “Swelling and diffusion studies of calcium polysaccharide gels intended for film coating,” International Journal of Pharmaceutics, Vol. 358, 2008, pp. 205-213.

[10] Y. Sakata and M. Otsuka, “Evaluation of relationship between molecular behavior and mechanical strength of pullulan films,” International Journal of Pharmaceutics, Vol. 374, 2009, pp. 33-38.

[11] A. M. Smith, A. Ingham, L. M. Grover and Y. Perrie, “Polymer film formulations for the preparation of enteric pharmaceutical capsules,” Journal of Pharmacy and Pharmacology, Vol. 62, 2010, pp. 167-172.

[12] J. Alamed, W. Chaiyasit, D. J. McClements and E. A. Decker, “Relationships between free radical scavenging and antioxidant activity in foods,” Journal of Agricultural and Food Chemistry, Vol. 57, No. 7, 2009, pp. 2969- 2976.

[13] M. Ohnishi, T. Matsuo, T. Tsuno, A. Hosoda, E. Nomura, H. Taniguchi, H. Sasaki and H. Morishita, “Antioxidant activity and hypoglycemic effect of ferulic acid in STZ- induced diabetic mice and KK-Ay mice,” Biofactors, Vol. 21, No. 1-47, 2004, pp. 315-319.

[14] A. Suzuki, D. Kagawa, A. Fujii, R. Ochiai, I. Tokimitsu and I. Saito, “Short- and long-term effects of ferulic acid on blood pressure in spontaneously hypertensive rats,” American Journal of Hypertension, Vol. 15, No. 4, 2002, pp. 351-357.

[15] B. Wang, J. Ouyang, Y. Liu, J. Yang, L. Wei, K. Li and H. Yang, “Sodium ferulate inhibits atherosclerogenesis in hyperlipidemia rabbits,“ Journal of Cardiovascular Pharmacology, Vol. 43, No. 4, 2004, pp. 549-554.

[16] K. Hamaishi, R. Kojima and M. Ito, “Anti-ulcer effect of tea catechin in rats,” Biological and Pharmaceutical Bulletin, Vol. 29, No. 11, 2006, pp. 2206-2213.

[17] X. Xu, X. D. Zhou and C. D. Wu, “The tea catechin epigallocatechin gallate suppresses cariogenic virulence factors of Streptococcus mutans,” Antimicrobial Agents and Chemotherapy, Vol. 55, No. 3, 2011, pp. 1229-1236.

[18] S. M. S. Miguel, L. A. Opperman, E. P. Allen, J. Zielinski and K. K. H. Svoboda, “Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells,” Journal of Periodontology, Vol. 81, No. 11, 2010, pp. 1675-1690.

[19] M. Kohno, S. Suzuki,T. Kanaya, T. Yoshino, Y. Matsuura, M. Asada and S. Kitamura, “Structural characterization of the extracellular polysaccharide produced by Bifidobacterium longum JBL05,” Carbohydate Polymers, Vol. 77, 2009, pp. 351-357.

[20] Y. Murata, K. Nagaki, K. Kofuji and T. Kishi, “Functions of chitosan- ferulic acid salt for prevention of hypertension,” Food Science and Technology Research, Vol. 16, No. 5, 2010, pp. 437-442.

[21] T. Fu, J. Liang, G. Han, L. Lv and N. Li, “Simultaneous determination of the major active components of tea polyphenols in rat plasma by a simple and specific HPLC assay,” Journal of Chromatography B, Vol. 875, 2008, pp. 363-367.

[22] B. Nauntofte, J. O. Tenovuo and F. Lagerlof, “Secretion and composition of saliva. In Dental Caries the Disease and Its Clinical Management“ (O. Fejerskov and E. A. M. Kidd, Eds. Chapter 2, pp. 7-27, Blackwell Munksgaad, Oxford, UK), 2003.