ABCR  Vol.5 No.1 , January 2016
The Role of Serum Trace Elements and Oxidative Stress in Egyptian Breast Cancer Patients
Abstract: Background: Oxidative stress is considered to be involved in the pathophysiology of all cancers. Studies indicated that the levels of oxidative stress markers increased in breast cancer. Trace metals are essential to normal human homeostasis. When present in an abnormal expression, they contribute in many pathological processes. Some trace metals are claimed to be carcinogenic and capable of inducing a toxic effect through the formation of free radicles and acting as cofactors in the oxidative damage of biological macromolecules and DNA. Objective: Our aim was to investigate the serum levels of some trace elements (Copper, Zinc and Cadmium), the total oxidative and anti-oxidative capacity (TOC and TAC) in patients with breast cancer in comparison to patients with benign breast tumours. Patients and Methods: The present study included 65 females. The participates were divided into 2 main groups: control group which consisted of 20 apparently healthy female; the patient groups which divided into 3 groups: group B included 15 patients with benign breast tumours, group N consisted of 15 newly diagnosed breast cancer patients and group M included 15 patients with metastatic breast cancer. Results: The mean serum levels of Copper, Zinc, and Cadmium were significantly higher in the three patients groups (B, N and M) than the control group. Similarly, serum uric acid (UA) and (TAC) levels showed significant higher level in both breast cancer groups as compared to the benign group. However TOC levels showed only significantly higher level in metastatic group. Conclusions: The present study suggested elevated TAC, UA and TOC in breast cancer patients. The increased levels of trace elements could lead to formation of free radicals or other reactive oxygen species. The serum profile of these trace metals may be helpful in predicting prognosis of breast cancer.
Cite this paper: El-Deeb, M. , El-Sheredy, H. and Mohammed, A. (2016) The Role of Serum Trace Elements and Oxidative Stress in Egyptian Breast Cancer Patients. Advances in Breast Cancer Research, 5, 37-47. doi: 10.4236/abcr.2016.51004.

[1]   Parkin, D.M. and Fernández, L.M. (2006) Use of Statistics to Assess the Global Burden of Breast Cancer. Breast Journal, 1, 70-80.

[2]   Amal, S.I., Hussein, M.K., Nabiel, N.M., Hoda, B. and Hossam, K. (2014) Cancer Incidence in Egypt: Results of the National Population-Based Cancer Registry Program. Journal of Cancer Epidemiology, 18, Article ID: 437971.

[3]   Dumitrescu, R.G. and Cotarla, I. (2005) Understanding Breast Cancer Risk. Where Do We Stand in 2005? Journal of Cellular and Molecular Medicine, 9, 208-221.

[4]   Halliwell, B. and Gutteridge, J.M. (2006) Free Radicals in Biology and Medicine. 4th Edition, Clarendon Press, Oxford.

[5]   Halliwell, B. (2007) Oxidative Stress and Cancer: Have We Moved Forward? Biochemical Journal, 401, 1-11.

[6]   Badid, N., Ahmed, F.Z., Merzouk, H., Belbraouet, S., Mokhtari, N. and Merzouk, S.A. (2010) Oxidant/Antioxidant Status, Lipids and Hormonal Profile in Overweight Women with Breast Cancer. Pathology and Oncology Research, 16, 159-167.

[7]   Kasapovic, J., Pejic, S., Todorovic, A., Stojiljkovic, V. and Pajovic, S.B. (2008) Antioxidant Status and Lipid Peroxidation in the Blood of Breast Cancer Patients of Different Ages. Cell Biochemistry & Function, 26, 723-730.

[8]   Jevtic, M., Velicki, R., Popovic, M., Cemerlic-Adjic, N., Babovic, S.S. and Velicki, L. (2010) Dietary Influence on Breast Cancer. Journal of BUON, 15, 455-461.

[9]   Yeon, J.Y., Suh, Y.J., Kim, S.W., Baik, H.W., Sung, C.J., Kim, H.S. and Sung, M.K. (2011) Evaluation of Dietary Factors in Relation to the Biomarkers of Oxidative Stress and Inflammation in Breast Cancer Risk. Nutrition, 27, 912-918.

[10]   Muraoka, S. and Miura, T. (2003) Inhibition by Uric Acid of Free Radicals That Damage Biological Molecules. Basic & Clinical Pharmacology & Toxicology, 93, 284-289.

[11]   Aghvami, T., Djalali, M. and Kesharvarz, A. (2006) Plasma Level of Antioxidant Vitamins and Lipid Peroxidation in Breast Cancer Patients. Iranian Journal of Public Health, 35, 42-47.

[12]   Bertini, I. and Cavallaro, G. (2008) Metals in the “Omics” World: Copper Homeostasis and Cytochrome c Oxidase Assembly in a New Light. JBIC Journal of Biological Inorganic Chemistry, 13, 3-14.

[13]   Navoro, S.S. and Rohan, T.E. (2007) Trace Elements and Cancer Risk: A Review of the Epidemiologic Evidence. Cancer Causes Control, 18, 7-27.

[14]   Leonard, S.S., Bower, J.J. and Shi, X. (2004) Metal-Induced Toxicity, Carcinogenesis, Mechanisms and Cellular Responses. Molecular and Cellular Biochemistry, 255, 3-10.

[15]   Silva, A. and Poletti, M.E. (2009) Determination of Ca, Fe, Cu and Zn and Their Correlations in Breast Cancer and Normal Adjacent Tissues. X-Ray Spectrometry, 38, 103-111.

[16]   Trachootham, D., Lu, W., Ogasawara, M.A., Nilsa, R.D. and Huang, P. (2008) Redox Regulation of Cell Survival. Antioxidants & Redox Signaling, 10, 1343-1374.

[17]   Dastgheib, L., Mostafavi-Pour, Z., Abdorazagh, A.A., Khoshdel, Z., Sadat Sadati, M. and Ahrari, I. (2014) Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal Group. Dermatology Research and Practice, 2014, Article ID: 784863.

[18]   Gallagher, C.M., Chen, J.J. and Kovach, J.S. (2010) Environmental Cadmium and Breast Cancer Risk. Aging, 2, 804-814.

[19]   Alatise, O.I. and Schrauzer, G.N. (2010) Lead Exposure: A Contributing Cause of the Current Breast Cancer Epidemic in Nigerian Women. Biological Trace Element Research, 136, 127-139.

[20]   Shams, N., Said, S.B., Salem, T.A., Abdel-Rahman, R.H., Roshdy, S. and Abdel Rahman, R.H. (2012) Metal-Induced Oxidative Stress in Egyptian Women with Breast Cancer. The Egyptian Journal of Forensic Sciences and Applied Toxicology, 12, 187-199.

[21]   Mahmood, A.A., Bilal, K.M. and Ibrahim, R.T. (2012) Influence of Some Trace Elements and Biochemical Parameters on Breast Cancer. Journal of Education Science, 25, 34-43.

[22]   Sanjeev, K.G., Vijay, K.S., Vaidya, M.P. and Roy, S.K. (2006) Serum Trace Elements and Cu/Zn Ratio in Breast Cancer Patients. Journal of Surgical Oncology, 46, 178-181.

[23]   Abdel-Salam, O.M., Youness, E.R. and Hafez, H.F. (2011) The Antioxidant Status of the Plasma in Patients with Breast Cancer Undergoing Chemotherapy. Open Journal of Molecular and Integrative Physiology, 1, 29-35.

[24]   Siewit, C.L., Gengler, B., Vegas, E., Puckett, R. and Louie, M.C. (2010) Cadmium Promotes Breast Cancer Cell Proliferation by Potentiating the Interaction between ER Alpha and c-Jun. Molecular Endocrinology, 24, 981-992.

[25]   Arinola, O.G. and Charles-Davies, M.A. (2008) Micronutrient Levels in the Plasma of Nigerian Females with Breast Cancer. African Journal of Biotechnology, 7, 1620-1623.

[26]   Koracevic, D., Koracevic, G., Djordjevic, V., Andrejevic, S. and Cosic, V. (2001) Method for the Measurement of Antioxidant Activity in Human Fluids. Journal of Clinical Pathology, 54, 356-361.

[27]   Bhargava, A.K., Mathur, M., Diwan, R. and Bohra, V.D. (2015) Analysis of Serum Uric Acid and Bilirubin in Breast Cancer. International Journal of Scientific Research, 4, 2277-8179.

[28]   Krishna, V.G., Bhaskar, R.D., Muni, K.D., Usha, B., Murli, K.V. and Raghava, R.T. (2011) Clinical Evaluation of Oxidative Stress in Women with Breast Cancer. Recent Research in Science and Technology, 3, 55-58.

[29]   Burarah, A., Sameen, A., Mahjabeen, S., Rukhshan, K. and Muddasar, Z. (2012) Serum Trace Elements in Diagnosis of Breast Malignancy. Journal of Ayub Medical College, 24, 62-66.