JCPT  Vol.6 No.1 , January 2016
Crystal Type Iof Azilsartan Polymorphs: Preparation and Analysis
Abstract: Azilsartan (2-ethoxy-1-([2’-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl)-1H-benzimidazole-7-carboxylic acid) is a new angiotensin II receptor antagonist used in the treatment of hypertension. This paper describes the preparation of type I crystal and its single crystal diffraction data, the comparison of the powder diffraction data for both type I and II crystals as well as their stability and solubility in methanol.
Cite this paper: Ge, Y. , Li, T. and Cheng, J. (2016) Crystal Type Iof Azilsartan Polymorphs: Preparation and Analysis. Journal of Crystallization Process and Technology, 6, 1-10. doi: 10.4236/jcpt.2016.61001.

[1]   Singh, P., Fung, W.F. and Song, J.C. (2010) Focus on… Azilsartan: A Next-Generation Angiotensin II Receptor Blocker for the Treatment of Hypertension. Formulary, 45, 342-349.

[2]   Lam, S. (2011) Azilsartan: A Newly Approved Angiotensin II Receptor Blocker. Cardiology in Review, 19, 300-304.

[3]   Qiang, G., Lu, Y. and Du, G. (2009) The Present Situation and Development Direction of the Research for Polymorphic Drugs in China. Chinese Journal of New Drugs, 18, 1196-1200.

[4]   Xu, Y., Zhou, H., Liu, W. and He, G. (2013) Azilsartan Polymorph and Preparation Method Thereof. Chinese Patent CN103319473A.

[5]   Wang, X., Shui, Q., Tang, C., Liu, S., Ouyang, Q. and Shi, H. Azilsartan Crystal Form and Its Preparation and Application of the Same. Chinese Patent CN103880829A.

[6]   Chen, Q., Zhu, Y., Zhang, L. and Ding, L. (2012) Polycrystalline Substance of Azilsartan and Preparation Method Thereof. Chinese Patent CN102766139B.

[7]   Wu, B., Cui, H., Wang, J.and Wang, D. (2013) Hplc Analysis Method of Azilsartan. Chinese Patent CN103743826A.

[8]   Chen, X. and Cai, J. (2007) Single Crystal Structural Analysis: Principles and Practice. Science Press, Beijing, 127-128.

[9]   Steed, J.W. and Atwood, J.L. (2009) Supramolecular Chemistry. 2nd Edition, Wliley, Chichester.

[10]   Pranzo, M.B., Cruickshank, D., Coruzzi, M., Caira, M. R. and Bettini, R. (2010) Enantiotropically Related Albendazole Polymorphs. Journal of Pharmaceutical Sciences, 99, 3731-3742