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 Health  Vol.8 No.1 , January 2016
Search of Biomarker in the Oral Rehabilitation
Abstract: Are there any ways to analyze objectively if any good changes happen to the bodies for the patients with acquired edentulous by getting a treatment to recover occlusion? In this study, we focused on interleukin 6 (IL-6) as inflammatory cytokine, cortisol known as a stress related substance and secretory immune globulin A (SIgA) related to immune reaction, and chose 14 patients who had occlusion reconstructed by the immediately loaded dental implants because occlusion contact with maxillary and mandibular dentition was lost caused by edentulous jaws or maxillary and mandibular teeth crossing each other and their jaw position and central occlusion position could not settle, and verified the relationship with changes of patients’ physical and mental states during the 6 months of the treatment and the effect of the immediately loaded implants treatment by using saliva which was non-invasive and easy to sample in biomarkers in saliva. Moreover for female subjects, the changes of facial color tones were measured by using Robo Skin Analyz-er?, a digital image analyzer, to measure the condition of their skin. In conclusion, the positive correlation between the amount of IL-6 and cortisol was not admitted. However, it was admitted that IL-6 tended to increase when a systemic change which interrupted curing such as the interruption of fusion of the implant and the bone was observed even though the patient did not notice any particular symptoms and cortisol tended to increase when the patient noticed discomfort and mentioned any events under stress on his or her medical record. Moreover with the skin color analysis by Robo Skin Analyzer?, the possibility that the occlusion treatment by the immediate implant had an effect on physical and psychological health promotion through the acquisition of the masticatory function and the aesthetic recovery was indicated.
Cite this paper: Azuma, M. , Suzuki, S. , Sawa, M. , Yoshizawa, T. , Hu, A. , Yamaguchi, T. and Kobayashi, H. (2016) Search of Biomarker in the Oral Rehabilitation. Health, 8, 83-92. doi: 10.4236/health.2016.81010.
References

[1]   Maló, P., Rangert, B. and Nobre, M. (2003) “All-on-Four” Immediate-Function Concept with Branemark System Implants for Completely Edentulous Mandibles: A Retrospective Clinical Study. Clinical Implant Dentistry and Related Research, 5, 2-9.

[2]   Tarnow, D.P., Emtiaz, S. and Classi, A. (1997) Immediate Loading of Threaded Implants at Stage 1 Surgery in Edentulous Arches: Ten Consecutive Case Reports with 1- to 5-Year Data. The International Journal of Oral & Maxillofacial Implant, 12, 319-24.

[3]   Garg, A.K. (2007) Osstell Mentor: Measuring Dental Implant Stability at Placement, before Loading, and after Loading. Dent Implantol Update, 18, 49-53.

[4]   Kim, H., Kashiwagi, K. and Kawazoe, T. (2009) Measurement Errors for the Primary Stability of Implants Using a Wireless Resonance Frequency Analyzer. The Journal of the Osaka Odontological Society, 72, 69-76.

[5]   Hucklebridge, F., Clow, A. and Evans, P. (1998) The Relationship between Salivary Secretory Immunoglobulin A and Cortisol: Neuroendocrine Response to Awakening and the Diurnal Cycle. International Journal of Psychophysiology, 31, 69-76.
http://dx.doi.org/10.1016/S0167-8760(98)00042-7

[6]   Knutsson, U., Dahlgren, J., Marcus, C., Rosberg, S., Bronnegard, M., Stierna, P. and Albertsson-Wikland, K. (1997) Circadian Cortisol Rhythms in Healthy Boys and Girls: Relationship with Age, Growth, Body Composition, and Pubertal Development. The Journal of Clinical Endocrinology & Metabolism, 82, 536-403.

[7]   Akimoto, M., Miyazaki, M., Lee, H.-H., Nishimura, T., Tamura, M. and Miyakawa, M. (2009) Using Fuzzy Reasoning to Support System of Diagnosis of the Skin Disease. Bioimages, 17, 11-20.

[8]   Takiwaki, H. (1998) Measurement of Skin Color Using Reflectance Instruments and Image Analysis of the Skin. Cosmetic Stage. The Journal of Medical Investigation, 44, 121-126.

[9]   Misch, C.E. and Degidi, M. (2003) Five-Year Prospective Study of Immediate Early Loading of Fixed Prostheses in Completely Edentulous Jaws with a Bone Quality-Based Implant System. Clinical Implant Dentistry and Related Research, 5, 17-28.
http://dx.doi.org/10.1111/j.1708-8208.2003.tb00178.x

[10]   Albrektsson, T. and Sennerby, L. (1991) State of the Art in Oral Implants. Journal of Clinical Periodontology, 18, 474-481.
http://dx.doi.org/10.1111/j.1600-051X.1991.tb02319.x

[11]   Zarb, G.A. and Albrektsson, T. (1998) Consensus Report: Towards Optimized Treatment Outcomes for Dental Implants. Journal of Prosthetic Dentistry, 80, 641.

[12]   Lindh, C., Petersson, A. and Rohlin, M. (1996) Assessment of the Trabecular Pattern before Endosseous Implant Treatment: Diagnostic Outcome of Periapical Radiography in the Mandible. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 82, 335-343.
http://dx.doi.org/10.1016/S1079-2104(96)80363-5

[13]   Meredith, N., Alleyne, D. and Cawley, P. (1996) Quantitative Determination of the Stability of the Implant-Tissue Interface Using Resonance Frequency Analysis. Clinical Oral Implants Reseach, 7, 261-267.
http://dx.doi.org/10.1034/j.1600-0501.1996.070308.x

[14]   Johansson, P. and Strid, K.G. (1994) Assessment of Bone Quality from Placement Resistance during Implant Surgery. The International Journal of Oral & Maxillofacial Implant, 9, 279-288.

[15]   Olivé, J. and Aparicio, C. (1990) Periotest Method as a Measure of Osseointegrated Oral Implant Stability. The International Journal of Oral & Maxillofacial Implant, 5, 390-400

[16]   Kishimoto, T. (2005) Interleukin-6: From Basic Science to Medicine—40 Years in Immunology. Annual Review of Immunology, 23, 1-21.
http://dx.doi.org/10.1146/annurev.immunol.23.021704.115806

[17]   Hirano, T., Akira, S., Taga, T. and Kishimoto, T. (1990) Biological and Clinical Aspects of Interleukin 6. Immunol Today, 11, 443-449.
http://dx.doi.org/10.1016/0167-5699(90)90173-7

[18]   Ohzato, H., Yoshizaki, K., Nishimoto, N., Ogata, A., Tagoh, H., Monden, M., Gotoh, M., Kishimoto, T. and Mori, T. (1992) Interleukin-6 as a New Indicator of Inflammatory Status: Detection of Serum Levels of Interleukin-6 and C-Reactive Protein after Surgery. Surgery, 111, 201-209.

[19]   Gabay, C. and Kushner, I. (1999) Acute-Phase Proteins and Other Systemic Responses to Inflammation. The New England of Journal Medicine, 340, 448-454.

[20]   Douglas, R.G. and Shaw, J.H. (1989) Metabolic Response to Sepsis and Trauma. British Journal of Surgery, 76, 115- 122.

[21]   Levine, S.J., Larivée, P., Logun, C., Angus, C.W. and Shelhamer, J.H. (1993) Corticosteroids Differentially Regulate Secretion of IL-6, IL-8, and G-CSF by a Human Bronchial Epithelial Cell Line. American Journal of Physiology, 265, 360-368.

[22]   Kato, M., Suzuki, H., Murakami, M., Akama, M., Matsukawa, S. and Hashimoto, Y. (1997) Elevated Plasma Levels of Interleukin-6, Interleukin-8, and Granulocyte Colony-Stimulating Factor during and after Major Abdominal Surgery. Journal of Clinical Anesthesia, 9, 293-298.
http://dx.doi.org/10.1016/S0952-8180(97)00006-8

[23]   Kamagata, Y., Miyasaka, N., Inoue, H., Hashimoto, J. and Iida, M. (1989) Cytokine Production in Inflamed Human Gingival Tissues—Interleukin-6. Journal of Japanese Society of Periodontology, 31, 843-848.
http://dx.doi.org/10.2329/perio.31.843

[24]   Sugano, N. (1992) Study of Interleukin-6 Expres-sion in Periodontitis. Journal of Japanese Society of Periodontology, 34, 277-285.
http://dx.doi.org/10.2329/perio.34.277

[25]   Takahashi, K. (1992) Assessment of Interleukin-6 in the Progression of Disease. Journal of Japanese Society of Periodontology, 34, 286-300.
http://dx.doi.org/10.2329/perio.34.286

[26]   Takigawa, M. (1992) Study of Interleukin-6 Produced from Human Gingival Fibroblasts. Journal of Japanese Society of Periodontology, 34, 301-314.
http://dx.doi.org/10.2329/perio.34.301

[27]   Ito, H., Takata, T., Miyauchi, M., Ogawa, I. and Nikai, H. (1994) Immunohistochemical Localization of Interleukin-1α,Interleukin-1β and Interleukin-6 in Human Gingival Tissue. Journal of Japanese Society of Periodontology, 36, 545-551.
http://dx.doi.org/10.2329/perio.36.545

[28]   Yamaguchi, T. (2009) Enamel Protein Suppress Inflammatory Reaction. Journal of Japanese Society of Periodontology, 51, 38-50.
http://dx.doi.org/10.2329/perio.51.038

[29]   Hobo, S. (1984) A Kinematic Investigation of Mandibular Border Movement. Journal of Prosthetic Dentistry, 51, 642-646.
http://dx.doi.org/10.1016/0022-3913(84)90409-8

[30]   Glauser, R., Portmann, M., Ruhstaller, P., Lundgren, A.K., Hammerie, C.H. and Gottlow, J. (2001) Stability Measurements of Immediately Loaded Machined and Oxidized Implants in the Posterior Maxilla. A Comparative Clinical Study Using Response Frequency Analysis. Applied Osseointegration Research, 2, 27-29.

[31]   Cannon, W.B. (1914) The Emergency Function of the Adrenal Medulla in Pain and the Major Emotions. American Journal of Physiology, 33, 356-372.

[32]   Selye, H. (1936) A Syndrome Produced by Diverse Nocuous Agents. Nature, 138, 32.
http://dx.doi.org/10.1038/138032a0

[33]   Izawa, S. and Suzuki, K. (2007) The Comparison of Salivary Cortisol Immunoassay Kits: Correlations between Salivary and Plasma Cortisol Concentrations and Comparison of Immunoassay Methods. Japanese Journal of Complementary and Alternative Medicine, 4, 113-118.
http://dx.doi.org/10.1625/jcam.4.113

[34]   Ozawa, H. (2008) Neuronal Network for Regulation System of Stress, Feeding and Sexual Behavior. The Medical Association of Nippon Medical School, 4, 25-31.
http://dx.doi.org/10.1272/manms.4.25

[35]   tatsuo, M., Mitsunori, U., Hajime, I. and Masakazu, K. (2009) Stress Evaluation by the Stress Response Material in the Saliva and Effect by Bruxism. The Journal of Gifu dental Society, 36, 135-148.

[36]   Mori, K. and Akiyoshi, M. (1967) Marginal Periodontitis: A Histological Study of Incipient Stage. Journal of Periodontology, 38, 45-52.
http://dx.doi.org/10.1902/jop.1967.38.1.45

[37]   Vining, R.F., McGinley, R.A., Maksvytis, J.J. and Ho, K.Y. (1983) Salivary Cortisol: A Better Measure of Adrenal Cortical Function than Serum Cortisol. Annals of Clinical Biochemistry, 20, 329-335.
http://dx.doi.org/10.1177/000456328302000601

 
 
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