Back
 Health  Vol.8 No.1 , January 2016
Epidemiology of Sleep Disorders among Chronic Hemodialysis Patients in Senegal: A Multicentric Study
Abstract: Introduction: Sleep disorders (SD) are common dialysis patients and can impact their quality of life. In previous studies, black ethnicity was associated with higher incidence of SD but a few data are available in African patients. This study aimed to describe prevalence and risk factors of SD among Senegalese dialysis patients. Methods: We performed a cross-sectional study between February 15th and April 30th 2012 including 127 patients (75 males and 52 females) aged 46.8 ± 16.9 (16 - 85 years) and dialysed since >6 months in three dialysis centres. For each patient, we assessed insomnia according to international definition, obstructive sleep apnea syndrome (OSAS) with the Berlin questionnaire, restless leg syndrome (RLS) using abridged version of Cambridge-Hopkins RLS questionnaire, and excessive daytime sleepiness (EDS) with Epworth sleepiness scale. Logistic multivariate regression was used to identify factors associated with different SD. Results: Overall prevalence of SD was 88% comprising: insomnia (64.3%), OSAS (49.1%), RLS (24.1%) and EDS (20.5%). Forty-two patients presented at least two disorders. No difference was noticed in prevalence of SD between genders (p = 0.14). Level of blood pressure were not different across patients with and without SD. Insomnia correlated with anemia, inflammation and EDS. OSAS was associated with age ≥50 years, EDS and neck circumference ≥25 cm. RLS correlated with anemia and EDS. Other parameters such as gender, dialysis vintage, KT/V, obesity, diabetes status and hypoalbuminemia were not associated with the different SD. The majority of patients had not been diagnosed before the survey and none of them was under treatment. Conclusions: Our findings are compatible with high prevalence of sleep disorders reported in other populations. Insomnia and OSAS are the most frequent SD but some patients combined many disorders. Nephrologists should be more aware of these SD in order to detect them early and provide efficient treatment.
Cite this paper: Tondi, Z. , Seck, S. , Ka, E. , Cisse, M. , Dia, A. , Dia, D. , Diouf, B. and Gueye, L. (2016) Epidemiology of Sleep Disorders among Chronic Hemodialysis Patients in Senegal: A Multicentric Study. Health, 8, 42-48. doi: 10.4236/health.2016.81006.
References

[1]   Khalil, E.S., Mohamed, E.I., Khalil, G.I., et al. (2013) Effects of Sleep Disordered Breathing on Functional Capacity and Quality of Life in Chronic Kidney Disease Egyptian Patients. Sleep Breath, 17, 621-628.
http://dx.doi.org/10.1007/s11325-012-0732-0

[2]   Plantinga, L., Lee, K., Inker, L.A., et al. (2011) Association of Sleep-Related Problems with CKD in the United States, 2005-2008. American Journal Kidney Disease, 58, 554-564.
http://dx.doi.org/10.1053/j.ajkd.2011.05.024

[3]   Bastos, J.P., Sousa, R.B., Nepomuceno, L.A., Gutierrez-Adrianzen, O.A., et al. (2007) Sleep Disturbances in Patients on Maintenance Hemodialysis: Role of Dialysis Shift. Revista Associacao Medica Brasileira, 53, 492-496.
http://dx.doi.org/10.1590/S0104-42302007000600014

[4]   Ezzat, H. and Mohab, A. (2015) Prevalence of Sleep Disorders among ESRD Patients. Renal Failure, 11, 1-7.
http://dx.doi.org/10.3109/0886022x.2015.1044401

[5]   Association, A.A.S.D. (1997) International Classification of Sleep Disorders, Revised: Diagnostic and Coding Manuals. American Sleep Disorders Association, Rochester.

[6]   Netzer, N.C., Stoohs, R.A., Netzer, C.M., et al. (1999) Using the Berlin Questionnaire to Identify Patients at Risk for the Sleep Apnea Syndrome. Annals of Internal Medicine, 131, 485-491.
http://dx.doi.org/10.7326/0003-4819-131-7-199910050-00002

[7]   Gholamrezaei, A. and Saadatnia, M. (2013) Application of the Cambridge-Hopkins Diagnostic Questionnaire for Investigating Restless Legs Syndrome in Patients with Chronic Renal Failure. Sleep Medicine, 14, 225.
http://dx.doi.org/10.1016/j.sleep.2012.09.002

[8]   Johns, M.W. (1991) A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale. Sleep, 14, 540- 545.

[9]   Parker, K.P. (2003) Sleep Disturbances in Dialysis Patients. Sleep Medicine Review, 7, 131-143.
http://dx.doi.org/10.1053/smrv.2001.0240

[10]   Masoumi, M., Naini, A.E., Aghaghazvini, R., et al. (2013) Sleep Quality in Patients on Maintenance Hemodialysis and Peritoneal Dialysis. International Journal of Preventive Medicine, 4, 165-172.

[11]   Merlino, G., Gigli, G.L. and Valente, M. (2008) Sleep Disturbances in Dialysis Patients. Journal of Nephrology, 21, S66-S70.

[12]   Muller, M.E., Heinzer, R., Pruijm, M., et al. (2012) Troubles du sommeil chez des patients présentant une insuffisance rénale chronique. Revue Médicale Suisse, 8, 458-461.

[13]   Al-Jahdali, H. (2012) Prevalence of Sleep Apnea and Excessive Day Time Sleepiness in Patients with End-Stage Renal Disease on Dialysis. Saudi Journal of Kidney Diseases and Transplantation, 23, 251-261.

[14]   Sabry, A.A., Abo-Zenah, H., Wafa, E., et al. (2010) Sleep Disorders in Hemodialysis Patients. Saudi Journal of Kidney Diseases and Transplantation, 21, 300-305.

[15]   Kuhlmann, U., Becker, H.F., Birkhahn, M., et al. (2000) Sleep-Apnea in Patients with End-Stage Renal Disease and Objective Results. Clinical Nephrology, 53, 460-466.

[16]   Hui, D.S., Wong, T.Y., Li, T.S., et al. (2002) Prevalence of Sleep Disturbances in Chinese Patients with End Stage Renal Failure on Maintenance Hemodialysis. Medical Sciences Monitoring, 8, CR331-CR336.

[17]   Sim, J.J., Rasgon, S.A., Kujubu, D.A., et al. (2009) Sleep Apnea in Early and Advanced Chronic Kidney Disease: Kaiser Permanente Southern California Cohort. Chest, 135, 710-716.
http://dx.doi.org/10.1378/chest.08-2248

[18]   Elias, R.M., Chan, C.T., Paul, N., et al. (2013) Relationship of Pharyngeal Water Content and Jugular Volume with Severity of Obstructive Sleep Apnea in Renal Failure. Nephrology Dialysis and Transplantation, 28, 937-944.
http://dx.doi.org/10.1093/ndt/gfs473

[19]   Kutner, N.G., Zhang, R., Huang, Y., et al. (2012) Racial Differences in Restless Legs Symptoms and Serum Ferritin in an Incident Dialysis Patient Cohort. International Journal of Urology Nephrology, 44, 1825-1831.
http://dx.doi.org/10.1007/s11255-011-0108-6

[20]   Yazdi, Z., Sadeghniiat-Haghighi, K., Kazemifar, A.M., et al. Saudi Journal of Kidney Diseases and Transplantation, 26, 625-660.

[21]   Losso, R.L., Minhoto, G.R. and Riella, M.C. (2015) Sleep Disorders in Patients with End-Stage Renal Disease Undergoing Dialysis: Comparison between Hemodialysis, Continuous Ambulatory Peritoneal Dialysis and Automated Peritoneal Dialysis. International Journal of Urology Nephrology, 47, 369-375.
http://dx.doi.org/10.1007/s11255-014-0860-5

[22]   Parker, K.P. (2006) Sleep and Dialysis: A Research-Based Review of the Literature. American Nephrology Nurses’ Association Journal, 6, 7626-7639.

[23]   Sabbatini, M., Pisani, A., Crispo, A., et al. (2002) Sleep Quality in Patients with Chronic Renal Failure: A 3-Year Longitudinal Study. Sleep Medicine, 9, 240-246.
http://dx.doi.org/10.1016/j.sleep.2007.04.005

[24]   Elder, S.J., Pisoni, R.L., Akizawa, T., et al. (2008) Sleep Quality Predicts Quality of Life and Mortality Risk in Haemodialysis Patients: Results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrology Dialysis and Transplantation, 23, 998-1004.
http://dx.doi.org/10.1093/ndt/gfm630

 
 
Top