Back
 MSCE  Vol.4 No.1 , January 2016
In Vivo Investigation of Zr-Based Bulk Metallic Glasses Sub-Periosteally Implanted on the Bone Surface
Abstract:

Bulk metallic glasses (BMG) show higher strength and lower Young’s modulus than SUS 316L stainless steel and Ti-6Al-4V alloys. This study aimed to investigate the reaction of Zr-based BMG sub-periosteally implanted on the surface of the rat femur, thereby evaluate the possibility of the BMG as biomaterials for osteosynthetic devices. Zr65Al7.5Ni10Cu17.5 BMG ribbons with 10 mm length, 2 mm width and 0.5 mm thickness were implanted sub-periosteally on the femur surface in three male Wistar rats for 6 weeks. Systemic effects were evaluated by measuring Cu and Ni levels in the blood, and local effects were evaluated by the histological observation of the surrounding soft tissues in contact with the BMG. The reaction of the surface of the BMG was examined with scanning electron microscopy. No increase of Cu and Ni levels in the blood was recognized. In the scanning electron microscopy observation, spherical deposits which were considered as sodium chloride crystals were observed. Neither breakage nor pitting corrosion was noted. BMG will be a promising metallic biomaterial for osteosynthetic device that must be removed.

Cite this paper: Imai, K. (2016) In Vivo Investigation of Zr-Based Bulk Metallic Glasses Sub-Periosteally Implanted on the Bone Surface. Journal of Materials Science and Chemical Engineering, 4, 46-51. doi: 10.4236/msce.2016.41009.
References

[1]   Inoue, A., Zhang, T. and Masumoto, T. (1995) Preparation of Bulky Amorphous Zr-Al-Ni-Cu Alloys by Copper Mold Casting and Their Thermal and Mechanical Properties. Materials Transactions JIM, 36, 391-398.

[2]   Hiromoto, S., Asami, K., Tsai, A-P., Sumita, M. and Hanawa, T. (2002) Surface Composition and Anodic Polarization Behavior of Zirconium-Based Amorphous Alloy with Various Alloying Elements in a Phosphate Buffered Saline Solution. Journal of Electrochemical Society, 149, B117-B122. http://dx.doi.org/10.1149/1.1456921

[3]   Hiromoto, S. and Hanawa, T. (2002) Re-Passivation Current of Amorphous Zr65Al7.5Ni10Cu17.5 Alloy in a Hanks' Balanced Solution. Electrochi-mica Acta, 47, 1343-1349. http://dx.doi.org/10.1016/S0013-4686(01)00876-3

[4]   Hiromoto, S., Tsai, A.-P., Sumita, M. and Hanawa, T. (2000) Effect of Chloride Ion on the Polarization Behavior of the Zr65Al7.5Ni10Cu17.5 Amorphous Alloy in Phosphate Buffered Solution. Corrosion Science, 42, 1651-1660. http://dx.doi.org/10.1016/S0010-938X(00)00022-6

[5]   Hiromoto, S., Tsai, A.-P., Sumita, M. and Hanawa, T. (2000) Effect of Surface Finishing and Dissolved Oxygen on the Polarization Behavior of Zr65Al7.5Ni10Cu17.5 Amorphous Alloy in Phosphate Buffered Solution. Corrosion Science, 42, 2167-2185. http://dx.doi.org/10.1016/S0010-938X(00)00043-3

[6]   Hiromoto, S., Tsai, A.-P., Sumita, M. and Hanawa, T. (2000) Effect of pH on the Polarization Behavior of Zr65Al7.5Ni10Cu17.5 Amorphous Alloy in a Phosphate Buffered Solution. Corrosion Science, 42, 2193-2200. http://dx.doi.org/10.1016/S0010-938X(00)00056-1

[7]   Hiromoto, S., Tsai, A-P., Sumita, M. and Hanawa, T. (2002) Surface Characterization of Zr-Al-(Ni, Cu) Amorphous Alloys Immersed in a Cell-Culture Medium. Materials Trans-actions JIM, 43, 261-266.

[8]   Morrison, M.L., Buchanan, R.A., Leon, R.V., Liu, C.T., Green, B.A., Liaw, P.K., et al. (2005) The Electrochemical Evaluation of a Zr-Based Bulk Metallic Glass in a Phosphate-Buffered Saline Electrolyte. J Biomed Mater Res A, 74, 430-438. http://dx.doi.org/10.1002/jbm.a.30361

[9]   Implant Committee of the Japanese Othopaedic Association (2000) Report of the Implant Survey. J. Jpn Orthop Assoc, 74, 525-534. (In Japa-nese)

[10]   Molster, A.O. (1986) Biomechanical Effects of Intramedullary Reaming and Nailing on Intact Femora in Rats. Clin Orthop, 202, 278-285.

[11]   Uhthoff, H.K. and Dubuc, F.L. (1971) Bone Structure Changes in the Dog under Rigid Internal Fixation. Clin Orthop, 81, 165-170. http://dx.doi.org/10.1097/00003086-197111000-00026

[12]   Bradley, G.W., McKenna, G.B., Dunn, H.K., Daniels, A.U. and Statton, W.O. (1979) Effects of Flexural Rigidity of Plates on Bone Healing. J Bone Joint Surg Am, 61, 866-872.

[13]   Woo, S.L., Akeson, W.H., Coutts, R.D., Rutherford, L., Doty, D., Jemmott, G.F., et al. (1976) A Comparison of Cortical Bone Atrophy Secondary to Fixation with Plates with Large Differences in Bending Stiffness. J Bone Joint Surg Am, 58, 190-195.

[14]   Tonino, A.J., Davidson, C.L., Klopper, P.J. and Linclau, L.A. (1976) Protection from Stress in Bone and Its Effects. Experiments with Stainless Steel and Plastic Plates in Dogs. J Bone Joint Surg Br, 58, 107-113.

[15]   Oonishi, H., Tsuji, E., Nabeshima, T., Kushitani, S., Tsuyama, K., Ukon, Y., et al. (1987) In Vitro and in Vivo Reactions of Various Amorphous Metals. Biomaterials and Clinical Applications, 541-546.

[16]   Imai, K. and Hiromoto, S. (2014) In Vivo Evaluation of Zr-Based Bulk Metallic Glass Alloy Intramedullary Nails in Rat Femora. J Mater Sci Mater Med, 25, 759-768. http://dx.doi.org/10.1007/s10856-013-5102-3

[17]   Shih, C.C., Lin, S.J., Chung, K.H., Chen, Y.L. and Su, Y.Y. (2000) Increased Corrosion Resistance of Stent Materials by Converting Current Surface Film of Polycrystalline Oxide into Amorphous Oxide. J Biomed Mater Res, 52, 323- 332. http://dx.doi.org/10.1002/1097-4636(200011)52:2<323::AID-JBM11>3.0.CO;2-Z

[18]   Takatsuka, K., Yamamuro, T., Nakamura, T. and Kokubo, T. (1995) Bone-Bonding Behavior of Titanium Alloy Evaluated Mechanically with Detaching Failure Load. J Biomed Mater Res, 29, 157-163. http://dx.doi.org/10.1002/jbm.820290204

 
 
Top