JBBS  Vol.5 No.13 , December 2015
The Selective Serotonin Reuptake Inhibitor-Sertraline Diminishes Conspecific Aggression in Male Fighting Betta splendens Fish
Abstract: In conspecific type of aggression the modulation of 5-hydroxytryptamine (5-HT) plays a main role. A decrease of 5-HT in the brain intensifies this type of aggression and in contrast, the increase of 5-HT reduces it. The aim of this study was to examine the effects of different concentrations of sertraline HCl on aggressive behavior of Betta splendens male fish. It was concluded that sertraline added to aquarium water in the dose of 0.4, 4.0 and/or 100.0 μg·L-1 BW during 14 days of exposition increased synaptic levels of 5-HT which in turn resulted in reduction of specific aggressive behavior in the environmental concentrations (0.4 μg) and then times higher. Sertraline caused a periodic, and sometimes even total weakening of the male-male type fight, which was a standard trial applied in ethological research on the Siamese fighting fish. In the current study, the most effective one is proved to be the dose of 4.0 μg·L-1 BW (parallel to earlier investigated fluoxetine in the same dose).
Cite this paper: Kania, B. and Wrońska, D. (2015) The Selective Serotonin Reuptake Inhibitor-Sertraline Diminishes Conspecific Aggression in Male Fighting Betta splendens Fish. Journal of Behavioral and Brain Science, 5, 578-585. doi: 10.4236/jbbs.2015.513055.

[1]   Brooks, B.W. (2014) Fish on Prozac (and Zoloft): Ten Years Later. Aquatic Toxicology, 151, 61-67.

[2]   Lynn, S.H., Edgar, J.M., Walker, B.G., Sperry, T.S. and Ramenovsky, M. (2007) Fish on Prozac: A Simple, Noninvasive Physiology Laboratory Investigating the Mechanisms of Aggressive Behavior in Betta splendens. Advances in Physiology Education, 31, 358-363.

[3]   Jaroensutasinee, M. and Jaroensutasinee, K. (2001) Sexual Size Dimorphism and Male Contest in Wild Siamese Fighting Fish. Journal of Fish Biology, 59, 161-162.

[4]   Abate, M.E. (2005) Using a Popular Pet Fish Species to Study Territorial Behavior. Journal of Biological Education, 39, 81-86.

[5]   Clotfelter, E.D. and Paolino, A.D. (2003) Bystanders to Contests between Conspecifics Are Primed for Increased Aggression in Male Fighting Fish. Animal Behaviour, 66, 343-347.

[6]   Kania, B.F., Gralak, M.A. and Wielgosz, M. (2012) Four-Week Fluoxetine (SSRI) Exposure Diminishes Aggressive Behavior of Male Siamese Fighting Fish (Betta splendens). Journal of Behavioral and Brain Science, 2, 185-190.

[7]   Daughton, C.G. and Brooks, B.W. (2011) Active Pharmaceutical Ingredients in Aquatic Organisms. In: Beyer, W.N. and Meador, J.P., Eds., Environmental Contaminants in Biota: Interpreting Tissue Concentrations, Chapter 8, 2nd Edition, CRC Press, Boca Ratton, 286-347.

[8]   Kolpin, D.W., Furlong, E.T., Meyer, M.T., Thurman, E.M., Zaugg, S.D., Barber, L.B. and Buxton, H.T. (2002) Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in the U.S. Streams, 1999-2000: A National Reconnaissance. Environmental Science & Technology, 36, 1202-1211.

[9]   Metcalfe, C.D., Chu, S., Judt, C., Li, H., Oakes, K.D., Servos, M.R. and Andrews, D.M. (2010) Antidepressants and Their Metabolites in Municipal Wastewater, and downstream Exposure in an Urban Watershed. Environmental Toxicology and Chemistry, 29, 79-89.

[10]   Schultz, M., Iversen-Bergmann, S., Andersen, H. and Schmoldt, A. (2012) Therapeutic and Toxic Blood Concentrations of Nearly 1000 Drugs and Other Xenobiotics. Critical Care, 16, R136.

[11]   Valenti, T.W., Gould, G.G., Berninegr, J.P., Connors, K.A., Keele, N.B., Prosser, K.N. and Brooks, B.W. (2012) Human Therapeutic Plasma Levels of the Selective Serotonin Reuptake Inhibitors (SSRI) Sertraline Decrease Serotonin Reuptake Transporter Binding and Shelter-Seeking Behavior in Adult Male Fathead Minnows. Environmental Science & Technology, 46, 2427-2435.

[12]   Gaworecki, A.K.M. and Klaine, S.J. (2008) Behavioral and Biochemical Responses of Hybrid Striped Bass during and after Fluoxetine Exposure. Aquatic Toxicology, 88, 207-213.

[13]   Kania, B.F., Debski, B., Wrońska, D. and Zawadzka, E. (2015) Verapamil—L Type Voltage Gated Calcium Channel Inhibitor Diminishes Aggressive Behavior in Male Siamese Fighting Fish. Polish Journal of Veterinary Sciences, 18, 401-406.

[14]   Perreault, H., Semsar, K. and Godwin, J. (2003) Fluoxetine Treatment Decreases Territorial Aggression in a Coral Reef Fish. Physiology & Behavior, 79, 719-724.

[15]   Clotfelter, E.D., Curren, L.J. and Murphy, C.E. (2006) Mate Choice and Spawing Success in the Fighting Fish Betta splendens: The Importance of Body Size, Display Behavior and Net Size. Ethology, 112, 1170-1178.

[16]   Verbeek, P., Iwamoto, T. and Muralkami, N. (2007) Differences in Aggression between Wild Type and Domesticated Fighting Fish Are Context Dependent. Animal Behaviour, 73, 75-83.

[17]   Clotfelter, E.D., O’Hare, E.P., McNitt, M.H., Carpenter, R.E. and Summers, C.H. (2007) Serotonin Decreases Aggression via 5-HT1A Receptors in the Fighting Fish Betta splendens. Pharmacology Biochemistry and Behavior, 87, 222-231.

[18]   Giebultowicz, J. and Nalecz-Jawecki, G. (2014) Occurrence of Antidepressant Residues in the Sewage-Impacted Vistula and Utrata Rivers and in Tap Water in Warsaw (Poland). Ecotoxicology and Environmental Safety, 104, 103-109.

[19]   Lorenzi, V., Carpenter, R.E., Summers, C.H., Early, R.L. and Grober, M.S. (2009) Serotonin, Social Status and Sex Change in the Bluebanded Goby Lythrypnusdalli. Physiology & Behavior, 97, 476-483.

[20]   Sanchez, C. (1997) Interaction Studies of 5-HT1A Receptor Antagonists and Selective 5-HT Reuptake Inhibitors on Isolated Aggressive Mice. European Journal of Pharmacology, 334, 127-132.

[21]   Sperry, T.S., Thompson, C.K. and Wingfield, J.C. (2003) Effects of Acute Treatment with 8-OH-DPAT and Fluoxetine on Aggressive Behavior in Male Song Sparrows (Melospiza melodia morphana). Journal of Neuroendocrinology, 15, 150-160.

[22]   Sperry, T.S., Moore, I.T., Meddle, S.L., Benowitz-Fredricks, A.M. and Wingfield, J.C. (2005) Increased Sensitivity of the Serotonergic System during the Breeding Season in Free-Living American Tree Sparrows. Behavioural Brain Research, 157, 119-126.

[23]   Harvey, A.T., Rudolph, R.L. and Preskorn, S.H. (2000) Evidence of Dual Mechanisms of Action of Venlafaxine. Archives of General Psychiatry, 57, 503-509.

[24]   Pae, C.U., Marks, D.M., Shah, M., Han, C., Ham, B.J., Patkar, A.A. and Masand, P.S. (2009) Milnacipran: Beyond a Role of Antidepressant. Clinical Neuropharmacology, 32, 355-363.

[25]   Pearsons, I.G. (2005) The Effects of Fluoxetine on Aggressive Behaviors in Siamese Figting Fish (Betta splendens). A Report of a Senior Study, Maryville College, Maryville, p. 11.