Health  Vol.7 No.12 , December 2015
Status of Vitamin B12 Deficiency in the Elderly Chinese Community People
Abstract: This study was aimed to investigate the vitamin B12 deficiency prevalence and symptoms in elderly people lived in a community of Shanghai, China. A total number of 962 elderly people resided in Shanghai community were recruited in the present study. They were 60 years and older, and the average age was 76.38 ± 13.68 years old. Information on previous and present diseases, currently prescribed and over-the-counter medication, and the presence or absence of symptoms relating to vitamin B12 deficiency were obtained by questionnaire. The levels of serum vitamin B12, folate and homocysteine (Hcy) were estimated. The patients with vitamin B12 deficiency were screened. The results of symptoms and positive signs of neurological examination were compared between subjects with or without vitamin B12 deficiency. The results showed that vitamin B12 deficiency was found in 130 persons (13.53% of the total subjects), with an increase in incidence with aging, only 10% of the vitamin B12 deficient subjects had megaloblastic anemia. The reported symptoms of vitamin B12 deficient subjects included fatigue, memory decline, dizziness, unsteadily walking in the darkness and hypopallesthesia. In conclusion, vitamin B12 deficiency was remarkably common in Chinese elderly people, with various and atypical clinical manifestations, and the neurological symptoms were more common than those of megaloblastic anemia.
Cite this paper: Wang, Y. , Zheng, Y. , Yan, F. and Zhang, W. (2015) Status of Vitamin B12 Deficiency in the Elderly Chinese Community People. Health, 7, 1703-1709. doi: 10.4236/health.2015.712185.

[1]   Dali-Youcef, N. and Andres, E. (2009) An Update on Cobalamin Deficiency in Adults. Quarterly Journal of Medicine, 102, 17-28.

[2]   Loikas, S., Koskinen, P., Irjala, K., Lopponen, M., Isoaho, R., Kivela, S.L., et al. (2007) Vitamin B12 Deficiency in the Aged: A Population-Based Study. Age and Ageing, 36, 177-183.

[3]   Wolters, M., Strohle, A. and Hahn, A. (2004) Cobalamin: A Critical Vitamin in the Elderly. Preventive Medicine, 39, 1256-1266.

[4]   Wang, Y.H., Yan, F., Zhang, W.B., Ye, G., Zheng, Y.Y. and Zhang, X.H., et al. (2009) An Investigation of Vitamin B12 Deficiency in Elderly Inpatients in Neurology Department. Neuroscience Bulletin, 25, 209-215.

[5]   Andres, E., Loukili, N.H., Noel, E., Kaltenbach, G., Abdelgheni, M.B., Perrin, A.E., et al. (2004) Vitamin B12 (Cobalamin) Deficiency in Elderly Patients. Canadian Medical Association Journal, 171, 251-259.

[6]   Obeid, R., Schorr, H., Eckert, R. and Herrmann, W. (2004) Vitamin B12 Status in the Elderly as Judged by Available Biochemical Markers. Clinical Chemistry, 50, 238-241.

[7]   Allen, L.H. (2009) How Common Is Vitamin B-12 Deficiency? The American Journal of Clinical Nutrition, 89, 693S-696S.

[8]   van Asselt, D.Z., Blom, H.J., Zuiderent, R., Wevers, R.A., Jakobs, C., van den Broek, W.J., et al. (2000) Clinical Significance of Low Cobalamin Levels in Older Hospital Patients. Netherlands Journal of Medicine, 57, 41-49.

[9]   Figlin, E., Chetrit, A., Shahar, A., Shpilberg, O., Zivelin, A., Rosenberg, N., et al. (2003) High Prevalences of Vitamin B12 and Folic Acid Deficiency in Elderly Subjects in Israel. British Journal of Haematology, 123, 696-701.

[10]   Shahar, A., Feiglin, L., Shahar, D.R., Levy, S. and Seligsohn, U. (2001) High Prevalence and Impact of Subnormal Serum Vitamin B12 Concentrations in Israeli Elders Admitted to a Geriatric Hospital. The Journal of Nutrition, Health & Aging, 5,124-127.

[11]   Yajnik, C.S., Deshpande, S.S., Lubree, H.G., Naik, S.S., Bhat, D.S., Uradey, B.S., et al. (2006) Vitamin B12 Deficiency and Hyperhomocysteinemia in Rural and Urban Indians. Journal of Association of Physicians of India, 54, 775- 782.

[12]   Gupta, A.K., Damji, A. and Uppaluri, A. (2004) Vitamin B12 Deficiency. Prevalence among South Asians at a Toronto Clinic. Canadian Family Physician, 50,743-747.

[13]   Clarke, R., Evans, J.G., Schneede, J., Nexo, E., Bates, C., Fletcher, A., et al. (2004) Vitamin B12 and Folate Deficiency in Later Life. Age and Ageing, 33, 34-41.

[14]   Reynolds, E. (2006) Vitamin B12, Folic Acid, and the Nervous System. The Lancet Neurology, 5, 949-960.

[15]   Moretti, R., Torre, P., Antonello, R.M., Cattaruzza, T., Cazzato, G. and Bava, A. (2004) Vitamin B12 and Folate Depletion in Cognition: A Review. Neurology India, 52, 310-318.

[16]   Bjorkegren, K. and Svardsudd, K. (2003) Reported Symptoms and Clinical Findings in Relation to Serum Cobalamin, Folate, Methylmalonic Acid and Total Homocysteine among Elderly Swedes: A Population-Based Study. Journal of Internal Medicine, 254, 343-352.

[17]   Hin, H., Clarke, R., Sherliker, P., Atoyebi, W., Emmens, K., Birks, J., et al. (2006) Clinical Relevance of Low Serum Vitamin B12 Concentrations in Older People: The Banbury B12 Study. Age and Ageing, 35, 416-422.

[18]   Carmel, R. (2000) Current Concepts in Cobalamin Deficiency. Annual Review of Medicine, 51, 357-375.

[19]   Puri, V., Chaudhry, N., Goel, S., Gulati, P., Nehru, R. and Chowdhury, D. (2005) Vitamin B12 Deficiency: A Clinical and Electrophysiological Profile. Electromyography and Clinical Neurophysiology, 45, 273-284.

[20]   Misra, U.K., Kalita, J. and Das, A. (2003) Vitamin B12 Deficiency Neurological Syndromes: A Clinical, MRI and Electrodiagnostic Study. Electromyography and Clinical Neurophysiology, 43, 57-64.

[21]   Pawlak, R., Parrott, S.J., Raj, S., Cullum-Dugan, D. and Lucus, D. (2013) How Prevalent Is Vitamin B12 Deficiency among Vegetarians? Nutrition Reviews, 71, 110-117.

[22]   Shipton, M.J. and Thachil, J. (2015) Vitamin B12 Deficiency—A 21st Century Perspective. Clinical Medicine, 15, 145-150.