JCDSA  Vol.5 No.4 , December 2015
Inter-Toe Cracks: A Cosmetic Response versus Excipient. Efficacy and Tolerance Evaluation
Abstract: A randomized, monocentric, double-blind, intra-individual excipient-controlled comparative study was performed to evaluate the efficacy and tolerance of an active peptide (laminin 5 fragment [LN-5]) formulated in cosmetic balm, versus excipient in inter-toe cracks. Two products were tested on 10 healthy volunteers. Each of them suffered from this particular superficial wound characterized by a peeling off a skin tab between at least two inter-toe spaces. The duration of this study belonged of 28 days with an intermediate visit to D14. Initial and outcome evaluation was performed using a 4-grade-scale depending on the severity of the inter-toe cracks. Tolerance and healing were assessed using macrophotographs. At D14 and D 28, the difference of cure between the 2 treatments was in favor of the peptide active product. The clinical score showed a best efficiency of the active compared with the excipient; indeed a significant difference between D28 and D0 was observed for the active ingredient. Active product repairs more quickly inter-toes cracks than the excipient and we noted the complete disappearance of the “severe” and “moderate” stages from the 14th day. This study showed clearly a fast (in 14 days) and beneficial effect of the application of LN-5 compared with the excipient, on the cutaneous repair of inter-toes cracks. Since LN-5 fragment is capable of producing immediate biological activity and reinforcing the dermal-epidermal junction, it can accelerate tissue repair.
Cite this paper: Jeudy, A. , Lihoreau, T. , Fanian, F. , Messikh, R. , Lafforgue, C. , Humbert, P. , (2015) Inter-Toe Cracks: A Cosmetic Response versus Excipient. Efficacy and Tolerance Evaluation. Journal of Cosmetics, Dermatological Sciences and Applications, 5, 291-296. doi: 10.4236/jcdsa.2015.54035.

[1]   Cribier, B. and Grosshans, E. (2002) Histologie de la peau normale et lésions histopathologiques élémentaires. Encycl Med Chir Dermatol, 98-085-A-10.

[2]   Rousselle, P., Douglas, R.K., Ruggiero, F., et al. (1997) Laminin 5 Binds the NC-1 Domain of Type VII Collagen. Journal of Cell Biology, 138, 719-728.

[3]   Decline, F. and Rousselle, P. (2001) Keratinocyte Migration Requires Alpha2 Beta1 Integrin Mediated Interaction with the Laminin 5 Gamma 2 Chain. Journal of Cell Science, 114, 811-823.

[4]   Hull, M.T. and Warfel, K.A. (1983) Age-Related Changes in the Cutaneous Basal Lamina: Scanning Electron Microscopic Studies. Journal of Investigative Dermatology, 81, 378-380.

[5]   Min, S.K., Lee, S.C., Hong, S.D., et al. (2010). The Effect of a Laminin-5-Derived Peptide Coated onto Chitin Microfibers on Re-Epithelialization in Early-Stage Wound Healing. Biomaterials, 31, 4725-4730.

[6]   Nguyen, B.P., Ryan, M.C., Gil, S.G. and Carter, W.G. (2000) Deposition of Laminin 5 in Epidermal Wounds Regulates Integrin Signaling and Adhesion. Current Opinion in Cell Biology, 12, 554-562.