ative Effectiveness of Epoetin Alfa after Addition of a Bacteriostatic Diluent. American Journal of Hospital Pharmacy, 49, 1455-1458.

[9]   Corwin, H.L., Gettinger, A., Fabian, T.C., May, A., Pearl, R.G., Heard, S., An, R., Bowers, P.J., Burton, P., Klausner, M.A. and Corwin, M.J. (2007) Efficacy and Safety of Epoetin Alfa in Critically Ill Patients. The New England Journal of Medicine, 357, 965-976.

[10]   Greif, F., Ben-Ari, Z., Taya, R., Pappo, O., Kurtzwald, E., Cheporko, Y., Ravid, A. and Hochhauser, E. (2010) Dual Effect of Erythropoietin on Liver Protection and Regeneration after Subtotal Hepatectomy in Rats. Liver Transplantation, 16, 631-638.

[11]   Lewis, L.D. (2004) Preclinical and Clinical Studies: A Preview of Potential Future Applications of Erythropoietic Agents. Seminars in Hematology, 41, 17-25.

[12]   Bogoyevitch, M.A. (2004) An Update on the Cardiac Effects of Erythropoietin Cardioprotection by Erythropoietin and the Lessons Learnt from Studies in Neuroprotection. Cardiovascular Research, 63, 208-216.

[13]   Yang, C.W., Li, C., Jung, J.Y., Shin, S.J., Choi, B.S., Lim, S.W., Sun, B.K., Kim, Y.S., Kim, J., Chang, Y.S. and Bang, B.K. (2003) Preconditioning with Erythropoietin Protects against Subsequent Ischemia-Reperfusion Injury in Rat Kidney. FASEB Journal, 17, 1754-1755.

[14]   Calvillo, L., Latini, R., Kajstura, J., Leri, A., Anversa, P., Ghezzi, P., Salio, M., Cerami, A. and Brines, M. (2003) Recombinant Human Erythropoietin Protects the Myocardium from Ischemia-Reperfusion Injury and Promotes Beneficial Remodeling. Proceedings of the National Academy of Sciences of the United States of America, 100, 4802-4806.

[15]   Erslev, A.J. (1991) Erythropoietin. New England Journal of Medicine, 324, 1339-1344.

[16]   Eschbach, J.W., Egrie, J.C., Downing, M.R., Browne, J.K. and Adamson, J.W. (1987) Correction of the Anemia of End-Stage Renal Disease with Recombinant Human Erythropoietin. Results of a Combined Phase I and II Clinical Trial. New England Journal of Medicine, 316, 73-78.

[17]   Siren, A.L. and Ehrenreich, H. (2001) Erythropoietin—A Novel Concept for Neuroprotection. European Archives of Psychiatry and Clinical Neuroscience, 251, 179-184.

[18]   Grasso, G. (2001) Neuroprotective Effect of Recombinant Human Erythropoietin in Experimental Subarachnoid Hemorrahage. Journal of Neurosurgery, 45, 7-14.

[19]   Taub, R. (2004) Liver Regeneration: From Myth to Mechanism. Nature Reviews Molecular Cell Biology, 5, 836-847.

[20]   Clavien, P.A., Petrowsky, H., De Oliveira, M.L. and Graf, R. (2007) Strategies for Safer Liver Surgery and Partial Liver Transplantation. New England Journal of Medicine, 356, 1545-1559.

[21]   Taub, R., Greenbaum, L.E. and Peng, Y. (1999) Transcriptional Regulatory Signals Define Cytokine-Dependent and Independent Pathways in Liver Regeneration. Seminars in Liver Disease, 19, 117-127.

[22]   Greif, F., Ben-Ari, Z., Taya, R., Pappo, O., Kurtzwald, E., Cheporko, Y., Ravid, A. and Hochhauser, E. (2010) Dual Effect of Erythropoietin on Liver Protection and Regeneration after Subtotal Hepatectomy in Rats. Liver Transplantation: Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 16, 631-638.

[23]   Schwabe, R.F., Bradham, C.A., Uehara, T., Hatano, E., Bennett, B.L., Schoonhoven, R. and Brenner, D.A. (2003) c-Jun-N-Terminal Kinase Drives Cyclin D1 Expression and Proliferation during Liver Regeneration. Hepatology, 37, 824-832.

[24]   Luedde, T., Rodriguez, M.E., Tacke, F., Xiong, Y., Brenner, D.A. and Trautwein, C. (2003) p18INK4c Collaborates with Other CDK Inhibitory Proteins in the Regenerating Liver. Hepatology, 37, 833-841.

[25]   Behrens, A., Sibilia, M., David, J.P., Muhle-Steinlein, U., Tronche, F., Schütz, G. and Wagner, E.F. (2002) Impaired Postnatal Hepatocyte Proliferation and Liver Regeneration in Mice Lacking c-Jun in the Liver. The EMBO Journal, 21, 1782-1790.

[26]   Talarmin, H., Rescan, C., Cariou, S., Glaise, D., Zanninelli, G., Bilodeau, M., Loyer, P., Guguen-Guillouzo, C. and Baffet, G. (1999) The Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Cascade Activation Is a Key Signaling Pathway Involved in the Regulation of G1 Phase Progression in Proliferating Hepatocytes. Molecular and Cellular Biology, 19, 6003-6011.

[27]   Sakamoto, T., Liu, Z., Murase, N., Ezure, T., Yokomuro, S., Poli, V. and Demetris, A.J. (1999) Mitosis and Apoptosis in the Liver of Interleukin-6-Deficient Mice after Partial Hepatectomy. Hepatology, 29, 403-411.

[28]   Yoshida, N., Iwata, H., Yamada, T., Sekino, T., Matsuo, H., Shirahashi, K., Miyahara, T., Kiyama, S. and Takemura, H. (2007) Improvement of the Survival Rate after Rat Massive Hepatectomy Due to the Reduction of Apoptosis by Caspase Inhibitor. Journal of Gastroenterology and Hepatology, 22, 2015-2021.

[29]   Neuman, M.G. (2001) Apoptosis in Diseases of the Liver. Critical Reviews in Clinical Laboratory Sciences, 38, 109-166.

[30]   Kahn, D., Hickman, R., Terblanche, J. and von Sommoggy, S. (1988) Partial Hepatectomy and Liver Regeneration in Pigs—The Response to Different Resection Sizes. The Journal of Surgical Research, 45, 176-180.

[31]   Bullwinkel, J., Baron-Lühr, B., Lüdemann, A., Wohlenberg, C., Gerdes, J. and Scholzen, T. (2006) Ki-67 Protein Is Associated with Ribosomal RNA Transcription in Quiescent and Proliferating Cells. Journal of Cellular Physiology, 206, 624-635.

[32]   Koskinas, J., Petraki, K., Kavantzas, N., Rapti, I., Kountouras, D. and Hadziyannis, S. (2005) Hepatic Expression of the Proliferative Marker Ki-67 and p53 Protein in HBV or HCV Cirrhosis in Relation to Dysplastic Liver Cell Changes and Hepatocellular Carcinoma. Journal of Viral Hepatitis, 12, 635-641.

[33]   Schmidt, M., Broll, R., Bruch, H. and Duchrow, M. (2002) The Proliferation Marker pKi-67 Becomes Masked to MIB-1 Staining after Expression of Its Tandem Repeats. Histochemistry and Cell Biology, 118, 415-422.

[34]   Humar, A., Kosari, K., Sielaff, T.D., Glessing, B., Gomes, M., Dietz, C., Rosen, G., Lake, J. and Payne, W.D. (2004) Liver Regeneration after Adult Living Donor and Deceased Donor Split-Liver Transplants. Liver Transplantation, 10, 374-378.

[35]   Pahlavan, P.S., Feldmann Jr., R.E., Zavos, C. and Kountouras, J. (2006) Prometheus’ Challenge: Molecular, Cellular and Systemic Aspects of Liver Regeneration. Journal of Surgical Research, 134, 238-251.

[36]   Savino, R. and Ciliberto, G. (2004) A Paradigm Shift for Erythropoietin: No Longer a Specialized Growth Factor, but Rather an All-Purpose Tissue-Protective Agent. Cell Death & Differentiation, 11, S2-S4.

[37]   Bockhorn, M., Fingas, C.D., Rauen, U., Canbay, A., Sotiropoulos, G.C., Frey, U., Sheu, S.Y., Wohlschlager, J., Broelsch, C.E. and Schlaak, J.F. (2008) Erythropoietin Treatment Improves Liver Regeneration and Survival in Rat Models of Extended Liver Resection and Living Donor Liver Transplantation. Transplantation, 86, 1578-1585.

[38]   Klemm, K., Eipel, C., Cantré, D., Abshagen, K., Menger, M.D. and Vollmar, B. (2008) Multiple Doses of Erythropoietin Impair Liver Regeneration by Increasing TNF-Alpha, the Bax to Bcl-xL Ratio and Apoptotic Cell Death. PLoS ONE, 3, e3924.

[39]   Katavetin, P., Tungsanga, K., Eiam-Ong, S. and Nangaku, M. (2007) Antioxidative Effects of Erythropoietin. Kidney International, 72, S10-S15.

[40]   Ehrenreich, H., Hasselblatt, M., Dembowski, C., Cepek, L., Lewczuk, P., Stiefel, M., Rustenbeck, H.H., Breiter, N., Jacob, S., Knerlich, F., Bohn, M., Poser, W., Rüther, E., Kochen, M., Gefeller, O., Gleiter, C., Wessel, T.C., De Ryck, M., Itri, L., Prange, H., Cerami, A., Brines, M. and Sirén, A.L. (2002) Erythropoietin Therapy for Acute Stroke Is Both Safe and Beneficial. Molecular Medicine, 8, 495-505.

[41]   Schmeding, M., Boas-Knoop, S., Lippert, S., Ruehl, M., Somasundaram, R., Dagdelen, T., Neuhaus, P. and Neumann, U.P. (2008) Erythropoietin Promotes Hepatic Regeneration after Extended Liver Resection in Rats. Journal of Gastroenterology and Hepatology, 23, 1125-1131.

[42]   Kahn, D., van Hoom-Hickman, R., Child, P. and Terblanche, J. (1984) Transhepatic Changes in Insulin and Glucagon Following Partial Hepatectomy in the Pig: The Effect of Hypoglycemia. Surgery, Gynecology & Obstetrics, 158, 475.

[43]   Kahn, D., Stadler, J., Terblanche, J. and van Hoom-Hickman, R. (1980) Thymidine Kinase: An Inexpensive Index of Liver Regeneration in a Large Animal Model. Gastroenterology, 79, 907-911.

[44]   Kahn, D., van Hoorn-Hickman, R. and Terblanche, J. (1984) Liver Blood Flow after Partial Hepatectomy in the Pig. Journal of Surgical Research, 37, 290-294.