JBM  Vol.3 No.11 , November 2015
Correlation between Dietary Intake and Inflammatory Biomarkers in a Tunisian Obese Group
ABSTRACT
Aims: This study aims to determine the inflammatory status and evaluate the correlation between dietary intake and inflammatory biomarkers in a Tunisian obese group. Material and Methods: This is an open cross-sectional study that includes 81 individuals divided into two groups: a group of 42 obese patients recruited from the endocrinology department and a control group of 39 non-obese healthy subjects. All participants received a food survey, anthropometric measurements and blood sampling. Pro-inflammatory cytokines (IL-6, IL-8, TNF-α), and hs-CRP were measured in patients and controls. Results: Dietary data revealed significant increases in food intake in obese patients compared to controls. The results of the laboratory parameters showed a statistically significant increase in IL-8, TNF-α and blood glucose in obese compared to controls. The analysis of correlations among the parameters studied showed that the plasma level of IL-6 was positively correlated with dietary fat intake (r = 0.70; p < 10-3) and carbohydrate (r = 0.54; p = 0.03) and the dietary intake expressed in calories (r = 0.64; p < 10-3). Conclusion: dietary imbalances in obese were observed and characterized by an excessive intake of calories, fat and carbohydrates. The excessive carbohydrate and fat intake is associated with increased IL-6 and TNF-α plasma levels.

Cite this paper
Ayoub, M. , Zouaoui, C. , Grira, N. , Kochkar, R. , Stambouli, N. , Bouguerra, C. , Zidi, B. , Ghazouani, E. , Mazigh, C. and Aouni, Z. (2015) Correlation between Dietary Intake and Inflammatory Biomarkers in a Tunisian Obese Group. Journal of Biosciences and Medicines, 3, 108-113. doi: 10.4236/jbm.2015.311014.
References
[1]   World Health Organization (2005) Fact Sheet: Obesity and Overweight.
http://www.who.int/dietphysicalactivity/publications/facts/obesity/en/

[2]   Joffe, Y.T., Collins, M. and Goedecke, J.H. (2013) The Relationship between Dietary Fatty Acids and Inflammatory Genes on the Obese Phenotype and Serum Lipids. Nutrients, 5, 1672-1705.
http://dx.doi.org/10.3390/nu5051672

[3]   World Health Organization (2008) Obesity [Internet]. WHO, Geneva.
http://www.who.int/topics/obesity/en/

[4]   Greenberg, A.S. and Obin, M.S. (2006) Obesity and the Role of Adipose Tissue in Inflammation and Metabolism. American Journal of Clinical Nutrition, 83, 461S-465S.

[5]   Galic, S., Oakhill, J.S. and Steinberg, G.R. (2010) Adipose Tissue as an Endocrine Organ. Molecular and Cellular Endocrinology, 316, 129-139.
http://dx.doi.org/10.1016/j.mce.2009.08.018

[6]   Galland, L. (2010) Diet and Inflammation. Nutrition in Clinical Practice, 10, 1164-1172.
http://dx.doi.org/10.1177/0884533610385703

[7]   Calder, P.C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., et al (2011) Dietary Factors and Low Grade Inflammation in Relation to Overweight and Obesity. British Journal of Nutrition, 106, S5-S78.
http://dx.doi.org/10.1017/s0007114511005460

[8]   Khosravi, R., Ka, K., Huang, T., Khalili, S., Hong Nguyen, B., Nicolau, B. and Simon, D. (2013) Tumor Necrosis Factor-α and Interleukin-6: Potential Interorgan Inflammatory Mediators Contributing to Destructive Periodontal Disease in Obesity or Metabolic Syndrome. Mediators of Inflammation, 2013, 1-6.
http://dx.doi.org/10.1155/2013/728987

[9]   Agarwal, N., Chitrika, A., Bhattacharjee, J. and Jain, S.K. (2011) Correlation of Tumour Necrosis Factor-α and Interleukin-6 with Anthropometric Indices of Obesity and Parameters of Insulin Resistance in Healthy North Indian Population. JIACM, 12, 196-204.

[10]   Pigeyre, M(2010). évolution des concepts physiopathologiques de l’obésité. La Presse Médicale, 39, 907-912.
http://dx.doi.org/10.1016/j.lpm.2010.05.015

[11]   Schlienger, J.-L.(2010) Conséquences pathologiques de l’obésité. La Presse Médicale, 39, 913-920.
http://dx.doi.org/10.1016/j.lpm.2010.04.018

[12]   De Boer, M.D. (2013) Obesity, Systemic Inflammation, and Increased Risk for Cardiovascular Disease and Diabetes among Adolescents: A Need for Screening Tools to Target Interventions. Nutrition, 29, 379-386.
http://dx.doi.org/10.1016/j.nut.2012.07.003

[13]   Neuparth, M.J., Proenca, J.B., Santos-Silva, A. and Coimbra, S. (2013) Adipokines, Oxidized Low-Density Lipoprotein, and C-Reactive Protein Levels in Lean, Overweight, and Obese Portuguese Patients with Type 2 Diabetes. ISRN obesity, 2013, Article ID: 142097.
http://dx.doi.org/10.1155/2013/142097

[14]   Kaur, J. (2014) A Comprehensive Review on Metabolic Syndrome. Cardiology Research and Practice, 2014, 1-22.
http://dx.doi.org/10.1155/2014/281483

[15]   Caldar, P.C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K. and Cunningham, K. (2011) Dietary Factors and Low-Grade Inflammation in Relation to Overweight and Obesity. BJN, 106, S1-S78.
http://dx.doi.org/10.1017/s0007114511005460

[16]   Fennira, E., Mahjoub, F., Abdesslem, H., Chaari, C., Gamoudi, A., Amrouche, C., et al. (2014) Alimentation de l’adolescent obèse tunisien: A propos de 108 cas. Nutrition Clinique et Métabolisme, 28, S155-S156.
http://dx.doi.org/10.1016/s0985-0562(14)70809-x

[17]   Lee, H., In, S. and Choue, R. (2013) Obesity, Inflammation and Diet. Pediatric Gastroenterology, Hepatology, and Nutrition, 3, 143-152.
http://dx.doi.org/10.5223/pghn.2013.16.3.143

[18]   Clément, K. and Vignes, S. (2009) Inflammation, adipokines et obésité. La Revue de Médecine Interne, 30, 824-832.
http://dx.doi.org/10.1016/j.revmed.2009.03.363

 
 
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