“Dermal Nitroglycerin Patch” in Treatment of Preterm Labour
ABSTRACT
Although preterm birth is the delivery before 37 + 0 weeks of gestation, the majority of prema-turity-related complications occur before 33 + 0 weeks of gestation. The need of today is to select the best agent out of the broad spectrum of available tocolytic agents, for providing maximum benefit to unfortunate sufferers of prematurity. The study aims to assess the role of “Dermal Nitroglycerin Patch” in treatment of preterm labour. Method: Study conducted in Department of Obstetrics & Gynecology, NIMS Medical College & Hospital, Jaipur from July 2014-December 2014. A prospective randomized study of 50 women of preterm labor was enrolled after informed consent. Patients were given dermal nitroglycerin patch as tocolytic agent according to study protocol. Result: 1) Results of NTG PATCH are comparable with other tocolytic drugs in terms of successful tocolysis; 2) Maternal and fetal outcome is favourable in cases of NTG PATCH USE in preterm labour; 3) Side effect profile was also better with NTG Patch. Conclusion: This randomized prospective study lends support to the proportion that Transdermal Nitroglycerine (NTG Patch) may be promising safe, effective, well tolerated, cost effective and non invasive method of tocolysis.
Although preterm birth is the delivery before 37 + 0 weeks of gestation, the majority of prema-turity-related complications occur before 33 + 0 weeks of gestation. The need of today is to select the best agent out of the broad spectrum of available tocolytic agents, for providing maximum benefit to unfortunate sufferers of prematurity. The study aims to assess the role of “Dermal Nitroglycerin Patch” in treatment of preterm labour. Method: Study conducted in Department of Obstetrics & Gynecology, NIMS Medical College & Hospital, Jaipur from July 2014-December 2014. A prospective randomized study of 50 women of preterm labor was enrolled after informed consent. Patients were given dermal nitroglycerin patch as tocolytic agent according to study protocol. Result: 1) Results of NTG PATCH are comparable with other tocolytic drugs in terms of successful tocolysis; 2) Maternal and fetal outcome is favourable in cases of NTG PATCH USE in preterm labour; 3) Side effect profile was also better with NTG Patch. Conclusion: This randomized prospective study lends support to the proportion that Transdermal Nitroglycerine (NTG Patch) may be promising safe, effective, well tolerated, cost effective and non invasive method of tocolysis.
Cite this paper
Shah, K. , Gupta, B. and Sharma, R. (2015) “Dermal Nitroglycerin Patch” in Treatment of Preterm Labour. Journal of Biosciences and Medicines, 3, 82-90. doi: 10.4236/jbm.2015.311011.
Shah, K. , Gupta, B. and Sharma, R. (2015) “Dermal Nitroglycerin Patch” in Treatment of Preterm Labour. Journal of Biosciences and Medicines, 3, 82-90. doi: 10.4236/jbm.2015.311011.
References
[1] Chopra, S. (1997) Preterm Labour: Use of Tocolytics for Prolongation of Pregnancy. Obstetric and Gynecology Today, 2, 28-30. [2] Abramovici, A., Cantu, J. and Jenkins, S.M. (2012) Tocolytic Therapy for Acute Preterm Labour. Obstetrics and Gynecology Clinics of North America, 39, 77-87.
http://dx.doi.org/10.1016/j.ogc.2011.12.003 [3] Cunnigham, F.G., Kenneth, K.J., Bloom, S.L., Hauth, J.C., Rouse, D.J. and Spong, C.Y. (2007) Williams Obstetrics. 23rd Edition, McGraw Hill Medical Publishing Division, New Delhi, 804-831. [4] Crowley, P. (2000) Prophylactic Corticosteroids for Preterm Birth. Cochrane Database of Systematic Reviews, 2, Article ID: CD000065. [5] Kumar, A., Bharadwaj, B. and Namita, P. (2001) Glyceryl Trinitrate Patch in Management of Pretermlabour. Journal of Obstetrics and Gynaecology of India, 51, 55-57. [6] Sachan, R., Gupta, P., Chaudhary, S. and Agarwal, R. (2012) Clinical Evaluation of Transdermal Nitroglycerine in Preterm Labor in Tertiary Care Teaching Hospital in North India. International Journal of Scientific and Research Publications, 2, 1-8. [7] Krishna, U. and Damle, D.S. (1996) Nitroglycerine Skin Patch Application for Tocolysis in Premature Onset of Labour. Journal of Obstetrics and Gynaecology Today, 1, 305-307.
[1] Chopra, S. (1997) Preterm Labour: Use of Tocolytics for Prolongation of Pregnancy. Obstetric and Gynecology Today, 2, 28-30. [2] Abramovici, A., Cantu, J. and Jenkins, S.M. (2012) Tocolytic Therapy for Acute Preterm Labour. Obstetrics and Gynecology Clinics of North America, 39, 77-87.
http://dx.doi.org/10.1016/j.ogc.2011.12.003 [3] Cunnigham, F.G., Kenneth, K.J., Bloom, S.L., Hauth, J.C., Rouse, D.J. and Spong, C.Y. (2007) Williams Obstetrics. 23rd Edition, McGraw Hill Medical Publishing Division, New Delhi, 804-831. [4] Crowley, P. (2000) Prophylactic Corticosteroids for Preterm Birth. Cochrane Database of Systematic Reviews, 2, Article ID: CD000065. [5] Kumar, A., Bharadwaj, B. and Namita, P. (2001) Glyceryl Trinitrate Patch in Management of Pretermlabour. Journal of Obstetrics and Gynaecology of India, 51, 55-57. [6] Sachan, R., Gupta, P., Chaudhary, S. and Agarwal, R. (2012) Clinical Evaluation of Transdermal Nitroglycerine in Preterm Labor in Tertiary Care Teaching Hospital in North India. International Journal of Scientific and Research Publications, 2, 1-8. [7] Krishna, U. and Damle, D.S. (1996) Nitroglycerine Skin Patch Application for Tocolysis in Premature Onset of Labour. Journal of Obstetrics and Gynaecology Today, 1, 305-307.