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 SS  Vol.6 No.11 , November 2015
Initial Experience of Face Augmentation Using Fat Graft-Platlet Rich Plasma Mix
Abstract: Plastic surgeons accustomed to use autologous fat grafs for augmentation of soft tissues in the last two decades. The main drawback of fat grafting is unpredictable graft resorption. Several studies have searched for new ways of increasing the viability of the transplanted tissue to overcome this disadvantage. The most recent and promising approach is to mix the fat graft with Platelet-Rich Plasma (PRP) before transplantation. The purpose of this article is to present the initial experience using the autologous fat injection with platlet rich plasma as a method for fascial augmentation.
Cite this paper: Tolba, A. and Nasr, M. (2015) Initial Experience of Face Augmentation Using Fat Graft-Platlet Rich Plasma Mix. Surgical Science, 6, 489-498. doi: 10.4236/ss.2015.611071.
References

[1]   Burgess, C.M. (2006) Principles of Soft Tissue Augmentation for the Aging Face. Clinical Interventions in Aging, 1, 349-355.
http://dx.doi.org/10.2147/ciia.2006.1.4.349

[2]   Bucky, L.P. and Kanchwala, S.K. (2007) The Role of Autologous Fat and Alternative Fillers in the Aging Face. Plastic and Reconstructive Surgery, 120, 89S-97S.
http://dx.doi.org/10.1097/01.prs.0000248866.57638.40

[3]   Neuber, G. (1893) über die Wiederanheilung vollstandig vom Korper getrennter, die ganze Fettschicht enthaltender Hautstücke. Zbl F Chirurgie, 30, 16.

[4]   Illouz, Y.G. (1986) The Fat Cell “Graft”: A New Technique to Fill Depressions. Plastic and Reconstructive Surgery, 78, 122-123.
http://dx.doi.org/10.1097/00006534-198607000-00028

[5]   Modarressi, A.S. (2013) Improvement of Fat Grafting with Platelet Rich Plasma: A Simple, Cost-Effective and Safe Method. Medical Grapevine, The Knowledge Bridge between GPS and Specialists.

[6]   Missana, M.C., Laurent, I., Barreau, L. and Balleyguier, C. (2007) Autologous Fat Transfer in Reconstructive Breast Surgery: Indications, Technique and Results. European Journal of Surgical Oncology, 33, 685-690.
http://dx.doi.org/10.1016/j.ejso.2006.12.002

[7]   Coleman, S.R. and Saboeiro, A.P. (2007) Fat Grafting to the Breast Revisited: Safety and Efficacy. Plastic and Reconstructive Surgery, 119, 775-785, 786-787.

[8]   Rong, J., Zhang, L. and Zhang, Y.G. (2013) Does Platelet-Rich Plasma Enhance the Survival of Grafted Fat? An Update Review. International Journal of Clinical and Experimental Medicine, 6, 252-258.

[9]   Barbara, D.B., Zvi, S., Thomas, E. and George, M. (2007) Clinical Use of Platelet-Rich Plasma in Orthopaedics. American Academy of Orthopaedic Surgeons, 9.

[10]   Shoshani, O., Livne, E., Armoni, M., Shupak, A., Berger, J., Ramon, Y., Fodor, L., Gilhar, A., Peled, I.J. and Ullmann, Y. (2005) The Effect of Interleukin-8 on the Viability of Injected Adipose Tissue in Nude Mice. Plastic and Reconstructive Surgery, 115, 853-859.
http://dx.doi.org/10.1097/01.PRS.0000153036.71928.30

[11]   Man, D., Plosker, H. and Winland-Brown, J.E. (2001) The Use of Autologous Platelet-Rich Plasma (Platelet Gel) and Autologous Platelet-Poor Plasma (Fibrin Glue) in Cosmetic Surgery. Plastic and Reconstructive Surgery, 107, 229-237; Discussion 238-239.
http://dx.doi.org/10.1097/00006534-200101000-00037

[12]   Marx, R.E., Carlson, E.R., Eichstaedt, R.M., et al. (1998) Platelet-Rich Plasma: Growth Factor Enhancement for Bone Grafts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 85, 638-646.
http://dx.doi.org/10.1016/S1079-2104(98)90029-4

[13]   Villela, D.L. and Santos, V.L. (2010) Evidence on the Use of Platelet-Rich Plasma for Diabetic Ulcer: A Systematic Review. Growth Factors, 28, 111-116.
http://dx.doi.org/10.3109/08977190903468185

[14]   Peerbooms, J.C., Sluimer, J., Bruijn, D.J. and Gosens, T. (2010) Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial: Platelet-Rich Plasma versus Corticosteroid Injection with a 1-Year Follow-Up. American Journal of Sports Medicine, 38, 255-262.
http://dx.doi.org/10.1177/0363546509355445

[15]   Tanidir, S.T., Yuksel, N., Altintas, O., et al. (2010) The Effect of Subconjunctival Platelet-Rich Plasma on Corneal Epithelial Wound Healing. Cornea, 29, 664-669.

[16]   Ebisawa, K., Kagami, H., Kato, R., et al. (2009) Regenerative Medicine for Anti-Aging. Nippon Rinsho, 67, 1402-1406.

[17]   Cervelli, V., Gentile, P., Scioli, M.G., Grimaldi, M., et al. (2009) Application of Platelet-Rich Plasma in Plastic Surgery: Clinical and in Vitro Evaluation. Tissue Engineering Part C: Methods, 15, 625-634.
http://dx.doi.org/10.1089/ten.tec.2008.0518

[18]   Adler, S.C. and Kent, K.J. (2002) Enhancing Wound Healing with Growth Factors. Facial Plastic Surgery Clinics of North America, 10, 129-146.
http://dx.doi.org/10.1016/S1064-7406(02)00005-6

[19]   Lacci, K.M. and Dardik, A. (2010) Platelet-Rich Plasma: Support for Its Use in Wound Healing. Yale Journal of Biology and Medicine, 83, 1-9.

[20]   Coleman, S.R. (1997) Facial Recontouring with Lipostructure. Clinics in Plastic Surgery, 24, 347-367.

[21]   Coleman, S.R. (2002) Hand Rejuvenation with Structural Fat Grafting. Plastic and Reconstructive Surgery, 110, 1731-1744; Discussion 1745-1747.
http://dx.doi.org/10.1097/00006534-200212000-00017

[22]   Cohen, G. and Treherne, A. (2009) Treatment of Facial Lipoatrophy via Autologous Fat Transfer. Journal of Drugs in Dermatology, 8, 486-489.

[23]   Serra-Renom, J.M. and Fontdevila, J. (2004) Treatment of Facial Fat Atrophy Related to Treatment with Protease Inhibitors by Autologous Fat Injection in Patients with Human Immunodeficiency Virus Infection. Plastic and Reconstructive Surgery, 114, 551-555; Discussion 556-557.
http://dx.doi.org/10.1097/01.PRS.0000128427.54445.63

[24]   Cervelli, V., Gentile, P. and Grimaldi, M. (2009) Regenerative Surgery: Use of Fat Grafting Combined with Platelet-Rich Plasma for Chronic Lower-Extremity Ulcers. Aesthetic Plastic Surgery, 33, 340-345.
http://dx.doi.org/10.1007/s00266-008-9302-z

[25]   Klinger, M., Marazzi, M., Vigo, D. and Torre, M. (2008) Fat Injection for Cases of Severe Burn Outcomes: A New Perspective of Scar Remodeling and Reduction. Aesthetic Plastic Surgery, 32, 465-469.
http://dx.doi.org/10.1007/s00266-008-9122-1

[26]   de Benito, J., Fernandez, I. and Nanda, V. (1999) Treatment of Depressed Scars with a Dissecting Cannula and an Autologous Fat Graft. Aesthetic Plastic Surgery, 23, 367-370.
http://dx.doi.org/10.1007/s002669900301

[27]   Lam, S.M., Glasgold, R.A. and Glasgold, M.J. (2008) Limitations, Complications, and Long-Term Sequelae of Fat Transfer. Facial Plastic Surgery Clinics of North America, 16, 391-399.
http://dx.doi.org/10.1016/j.fsc.2008.05.007

[28]   Coleman III, W.P. (1991) Autologous Fat Transplantation. Plastic and Reconstructive Surgery, 88, 736.
http://dx.doi.org/10.1097/00006534-199110000-00038

[29]   Kaufman, M.R., Bradley, J.P., Dickinson, B., et al. (2007) Autologous Fat Transfer National Consensus Survey: Trends in Techniques for Harvest, Preparation, and Application, and Perception of Short- and Long-Term Results. Plastic and Reconstructive Surgery, 119, 323-331.
http://dx.doi.org/10.1097/01.prs.0000244903.51440.8c

[30]   Eppley, B.L., Woodell, J.E. and Higgins, J. (2004) Platelet Quantification and Growth Factor Analysis from Platelet-Rich Plasma: Implications for Wound Healing. Plastic and Reconstructive Surgery, 114, 1502-1508.
http://dx.doi.org/10.1097/01.PRS.0000138251.07040.51

[31]   Cervelli, V., Gentile, P., Scioli, M.G., Grimaldi, M., Casciani, C.U., Spagnoli, L.G. and Orlandi, A. (2009) Application of Platelet-Rich Plasma in Plastic Surgery: Clinical and in Vitro Evaluation. Tissue Engineering Part C: Methods, 15, 625-634.
http://dx.doi.org/10.1089/ten.tec.2008.0518

[32]   Kakudo, N., Minakata, T., Mitsui, T., Kushida, S., Notodihardjo, F.Z. and Kusumoto, K. (2008) Proliferation-Promoting Effect of Platelet-Rich Plasma on Human Adipose-Derived Stem Cells and Human Dermal Fibroblasts. Plastic and Reconstructive Surgery, 122, 1352-1360.
http://dx.doi.org/10.1097/PRS.0b013e3181882046

[33]   Bendinelli, P., Matteucci, E., Dogliotti, G., Corsi, M.M., Banfi, G., Maroni, P. and Desiderio, M.A. (2010) Molecular Basis of Anti-Inflammatory Action of Platelet-Rich Plasma on Human Chondrocytes: Mechanisms of NF-κB Inhibition via HGF. Journal of Cellular Physiology, 225, 757-766.
http://dx.doi.org/10.1002/jcp.22274

[34]   Robiony, M., Polini, F., Costa, F. and Politi, M. (2002) Osteogenesis Distraction and Platelet-Rich Plasma for Bone Restoration of the Severely Atrophic Mandible: Preliminary Results. Journal of Oral and Maxillofacial Surgery, 60, 630-635.
http://dx.doi.org/10.1053/joms.2002.33107

[35]   Marx, R.E., Carlson, E.R., Eichstaedt, R.M., Schimmele, S.R., Strauss, J.E. and Georgeff, K.R. (1998) Plateletrich Plasma: Growth Factor Enhancement for Bone Grafts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 85, 638-646.
http://dx.doi.org/10.1016/S1079-2104(98)90029-4

[36]   Shiffman, M.A. and Kaminski, M.V. (2001) Fat Transfer to the Face: Technique and New Concepts. Facial Plastic Surgery Clinics of North America, 9, 229-37, viii.

[37]   Hee, H.T., Majd, M.E., Holt, R.T. and Myers, L. (2003) Do Autologous Growth Factors Enhance Transforaminal Lumbar Interbody Fusion? European Spine Journal, 12, 400-407.
http://dx.doi.org/10.1007/s00586-003-0548-5

[38]   Del Rossi, A.J., Cernaianu, A.C., Vertrees, R.A., Wacker, C.J., Fuller, S.J., Cilley, J.J. and Baldino, W.A. (1990) Platelet-Rich Plasma Reduces Postoperative Blood Loss after Cardiopulmonary Bypass. Journal of Thoracic and Cardiovascular Surgery, 100, 281-286.

[39]   Margolis, D.J., Kantor, J., Santanna, J., Strom, B.L. and Berlin, J.A. (2001) Effectiveness of Platelet Releasate for the Treatment of Diabetic Neuropathic Foot Ulcers. Diabetes Care, 24, 483-488.
http://dx.doi.org/10.2337/diacare.24.3.483

[40]   Ersek, R.A. (1991) Transplantation of Purified Autologous Fat: A 3-Year Follow-Up Is Disappointing. Plastic and Reconstructive Surgery, 87, 219-227; Discussion 228.
http://dx.doi.org/10.1097/00006534-199102000-00001

[41]   Chajchir, A. (1996) Fat Injection: Long-Term Follow-Up. Aesthetic Plastic Surgery, 20, 291-296.
http://dx.doi.org/10.1007/BF00228458

[42]   Rohrich, R.J., Sorokin, E.S. and Brown, S.A. (2004) In Search of Improved Fat Transfer Viability: A Quantitative Analysis of the Role of Centrifugation and Harvest Site. Plastic and Reconstructive Surgery, 113, 391-395; Discussion 396-397.
http://dx.doi.org/10.1097/01.prs.0000097293.56504.00

[43]   Adanali, G., Erdogan, B., Turegun, M., et al. (2002) A New, T-Shaped Adaptor for Easy, Quick and Efficient Fat Harvesting during Liposuction. Aesthetic Plastic Surgery, 26, 340-344.
http://dx.doi.org/10.1007/s00266-002-2040-8

[44]   Witort, E.J., Pattarino, J., Papucci, L., et al. (2007) Autologous Lipofilling: Coenzyme Q10 Can Rescue Adipocytes from Stress-Induced Apoptotic Death. Plastic and Reconstructive Surgery, 119, 1191-1199.
http://dx.doi.org/10.1097/01.prs.0000258395.81926.d8

[45]   Kuran, I. and Tumerdem, B. (2005) A New Simple Method Used to Prepare Fat for Injection. Aesthetic Plastic Surgery, 29, 18-22; Discussion 23.
http://dx.doi.org/10.1007/s00266-004-0059-8

[46]   Shiffman, M.A. and Kaminski, M.V. (2001) Fat Transfer to the Face: Technique and New Concepts. Facial Plastic Surgery Clinics of North America, 9, 229-237.

[47]   Marx, R.E. (2004) Platelet-Rich Plasma: Evidence to Support Its Use. Journal of Oral and Maxillofacial Surgery, 62, 489-496.
http://dx.doi.org/10.1016/j.joms.2003.12.003

[48]   Mazzucco, L., Balbo, V., Cattana, E., Guaschino, R. and Borzini, P. (2009) Not Every PRP-Gel Is Born Equal. Evaluation of Growth Factor Availability for Tissues through Four PRP-Gel Preparations: Fibrinet, RegenPRP-Kit, Plateltex and One Manual Procedure. Vox Sanguinis, 97, 110-118.
http://dx.doi.org/10.1111/j.1423-0410.2009.01188.x

[49]   Redaelli, A., Romano, D. and Marciano, A. (2010) Face and Neck Revitalization with Platelet-Rich Plasma (PRP): Clinical Outcome in a Series of 23 Consecutively Treated Patients. Journal of Drugs in Dermatology, 9, 466-472.

[50]   Assaf, A.Z., Patrick, L.T. and Alexis, M.V. (2012) Sharp-Needle Intradermal Fat Grafting (SNIF). Aesthetic Surgery Journal, 32, 554-561.
http://dx.doi.org/10.1177/1090820X12445082

[51]   Har-Shai, Y., Lindenbaum, E.S., Gamliel-Lazarovich, A., Beach, D. and Hirshowitz, B. (1999) An Integrated Approach for Increasing the Survival of Autologous Fat Grafts in the Treatment of Contour Defects. Plastic and Reconstructive Surgery, 104, 945-954.
http://dx.doi.org/10.1097/00006534-199909020-00008

[52]   Shoshani, O., Livne, E., Armoni, M., Shupak, A., Berger, J., Ramon, Y., Fodor, L., Gilhar, A., Peled, I.J. and Ullmann, Y. (2005) The Effect of Interleukin-8 on the Viability of Injected Adipose Tissue in Nude Mice. Plastic and Reconstructive Surgery, 115, 853-859.
http://dx.doi.org/10.1097/01.PRS.0000153036.71928.30

[53]   Ozsoy, Z., Kul, Z. and Bilir, A. (2006) The Role of Cannula Diameter in Improved Adipocyte Viability: A Quantitative Analysis. Aesthetic Surgery Journal, 26, 287-289.
http://dx.doi.org/10.1016/j.asj.2006.04.003

[54]   Ersek, R.A. (1991) Transplantation of Purified Autologous Fat: A Three Year Follow-Up Is Disappointing. Plastic and Reconstructive Surgery, 87, 219-227.
http://dx.doi.org/10.1097/00006534-199102000-00001

[55]   Fulton, J.E., Suarez, M., Silverton, K., et al. (1998) Small Volume Fat Transfer. Dermatologic Surgery, 24, 857-865.
http://dx.doi.org/10.1111/j.1524-4725.1998.tb04263.x

[56]   Fournier, P.F. (2000) Fat Grafting: My Technique. Dermatologic Surgery, 26, 1117-1128.
http://dx.doi.org/10.1046/j.1524-4725.2000.00272.x

[57]   Coleman, S.R. (1995) Long-Term Survival of Fat Transplants: Controlled Demonstrations. Aesthetic Plastic Surgery, 19, 421-425.
http://dx.doi.org/10.1007/BF00453875

[58]   Gentile, P., Di Pasquali, C., Bocchini, I., Floris, M., Eleonora, T., Fiaschetti, V., Floris, R. and Cervelli, V. (2012) Breast Reconstruction with Autologous Fat Graft Mixed with Platelet-Rich Plasma. Surgical Innovation, Epub Ahead of Print.

[59]   Salgarello, M., Visconti, G. and Rusciani, A. (2011) Breast Fat Grafting with Platelet-Rich Plasma: A Comparative Clinical Study and Current State of the Art. Plastic and Reconstructive Surgery, 127, 2176-2185.
http://dx.doi.org/10.1097/PRS.0b013e3182139fe7

 
 
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