OJRA  Vol.5 No.4 , November 2015
The Efficacy of Tocilizumab for Takayasu Arteritis: Review of the Literatures
Abstract: Takayasu arteritis is a large vessel vasculitis of the young women with giant cells and granuloma formation. The diagnosis and management of the disease are really not so easy because of the insidious onset and the difficulties in assessment of disease activity. Nearly 60% of the patients are corticosteroid resistant or dependent and relapses are very frequent during taper of the dose [1]. The novel biologic agents as Anti-TNF, Rutiximab and Tocilizumab provide acceptable response rates with low toxicity. Herein, we reviewed the efficacy of Tocilizumab in Takayasu arteritis.
Cite this paper: Yeşil, N. , Şahin, H. , Işik, M. , Aktop, Z. , Doğan, İ. and Baki, A. (2015) The Efficacy of Tocilizumab for Takayasu Arteritis: Review of the Literatures. Open Journal of Rheumatology and Autoimmune Diseases, 5, 118-125. doi: 10.4236/ojra.2015.54019.

[1]   Maksimowicz-McKinnon, K., Clark, T.M. and Hoffman, G.S. (2009) Takayasu Arteritis and Giant Cell Arteritis: A Spectrum within the Same Disease? Medicine, 88, 221-226.

[2]   Tso, E., Flamm, S.D., White, R.D., Schvartzman, P.R., Mascha, E. and Hoffman, G.S. (2002) Takayasu Arteritis: Utility and Limitations of Magnetic Resonance Imaging in Diagnosis and Treatment. Arthritis & Rheumatology, 46, 1634- 1642.

[3]   Hata, A., Noda, M., Moriwaki, R. and Numano, F. (1996) Angiographic Findings of Takayasu Arteritis: New Classification. International Journal of Cardiology, 54, S155-S163.

[4]   Lupi-Herrera, E., Sanchez-Torres, G., Marcushamer, J., Mispireta, J., Horwitz, S. and Vela, J.E. (1977) Takayasu’s Arteritis. Clinical Study of 107 Cases. American Heart Journal, 93, 94-103.

[5]   Arend, W.P., Michel, B.A., Bloch, D.A., Hunder, G.G., Calabrese, L.H., Edworthy, S.M., et al. (1990) The American College of Rheumatology 1990 Criteria for the Classification of Takayasu Arteritis. Arthritis & Rheumatology, 33, 1129-1134.

[6]   Dabague, J. and Reyes, P.A. (1996) Takayasu Arteritis in Mexico: A 38-Year Clinical Perspective through Literature Review. International Journal of Cardiology, 54, S103-S109.

[7]   Hall, S., Barr, W., Lie, J.T., Stanson, A.W., Kazmier, F.J. and Hunder, G.G. (1985) Takayasu Arteritis. A Study of 32 North American Patients. Medicine, 64, 89-99.

[8]   Ishikawa, K. (1978) Natural History and Classification of Occlusive Thromboaortopathy (Takayasu’s Disease). Circulation, 57, 27-35.

[9]   Koide, K. (1992) Takayasu Arteritis in Japan. Heart Vessels, 7, 48-54.

[10]   Kimura, A., Kitamura, H., Date, Y. and Numano, F. (1996) Comprehensive Analysis of HLA Genes in Takayasu Arteritis in Japan. International Journal of Cardiology, 54, S61-S69.

[11]   Takahashi, K., Oharaseki, T., Yokouchi, Y., Katsuzaki, J. and Enomoto, Y. (2014) Overview of the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides (CHCC2012). Nihon Jinzo Gakkai Shi, 56, 70-79.

[12]   Ozen, S., Pistorio, A., Iusan, S.M., Bakkaloglu, A., Herlin, T., Brik, R., et al. (2010) EULAR/PRINTO/PRES Criteria for Henoch-Schonlein Purpura, Childhood Polyarteritis Nodosa, Childhood Wegener Granulomatosis and Childhood Takayasu Arteritis: Ankara 2008. Part II: Final Classification Criteria. Annals of the Rheumatic Diseases, 69, 798-806.

[13]   Cong, X.L., Dai, S.M., Feng, X., Wang, Z.W., Lu, Q.S., Yuan, L.X., Zhao, X.X., Zhao, D.B. and Jing, Z.P. (2010) Takayasu’s Arteritis: Clinical Features and Outcomes of 125 Patients in China. Clinical Rheumatology, 29, 973-981.

[14]   Cid, M.C., Font, C., Coll-Vinent, B. and Grau, J.M. (1998) Large Vessel Vasculitides. Current Opinion in Rheumatology, 10, 18-28.

[15]   Lupi, E., Sanchez, G., Horwitz, S. and Gutierrez, E. (1975) Pulmonary Artery Involvement in Takayasu’s Arteritis. Chest, 67, 69-74.

[16]   Sharma, B.K., Jain, S. and Sagar, S. (1996) Systemic Manifestations of Takayasu Arteritis: The Expanding Spectrum. International Journal of Cardiology, 54, S149-S154.

[17]   Seko, Y., Minota, S., Kawasaki, A., Shinkai, Y., Maeda, K., Yagita, H., et al. (1994) Perforinsecreting Killer Cell Infiltration and Expression of a 65-kd Heat-Shock Protein in Aortic Tissue of Patients with Takayasu’s Arteritis. Journal of Clinical Investigation, 93, 750-758.

[18]   Kallenberg, C.G. and Tadema, H. (2008) Vasculitis and Infections: Contribution to the Issue of Autoimmunity Reviews Devoted to “Autoimmunity and Infection”. Autoimmunity Reviews, 8, 29-32.

[19]   Noris, M. (2001) Pathogenesis of Takayasu’s Arteritis. Journal of Nephrology, 14, 506-513.

[20]   Lupi-Herrera, E., Sanchez-Torres, G., Marcushamer, J., Mispireta, J., Horwitz, S. and Vela, J.E. (1977) Takayasu’s Arteritis. Clinical Study of 107 Cases. American Heart Journal, 93, 94-103.

[21]   Pryshchep, O., Ma-Krupa, W., Younge, B.R., Goronzy, J.J. and Weyand, C.M. (2008) Vessel-Specific Toll-Like Receptor Profiles in Human Medium and Large Arteries. Circulation, 118, 1276-1284.

[22]   Schultz, D.R. and Arnold, P.I. (1993) Heat Shock (Stress) Proteins and Autoimmunity in Rheumatic Diseases. Seminars in Arthritis and Rheumatism, 22, 357-374.

[23]   Arnaud, L., Haroche, J., Toledano, D., Cacoub, P., Mathian, A., Costedoat-Chalumeau, N., et al. (2011) Cluster Analysis of Arterial Involvement in Takayasu Arteritis Reveals Symmetric Extension of the Lesions in Paired Arterial Beds. Arthritis & Rheumatism, 63, 1136-1140.

[24]   Lv, N., Dang, A., Wang, Z., Zheng, D. and Liu, G. (2011) Association of Susceptibility to Takayasu Arteritis in Chinese Han Patients with HLA-DPB1. Human Immunology, 72, 893-896.

[25]   Flores-Dominguez, C., Hernandez-Pacheco, G., Zuniga, J., Gamboa, R., Granados, J., Reyes, P.A., et al. (2002) Alleles of the Major Histocompatibility System Associated with Susceptibility to the Development of Takayasu’s Arteritis. Gaceta Médica de México, 138, 177-183.

[26]   Vargas-Alarcon, G., Hernandez-Pacheco, G., Soto, M.E., Murguia, L.E., Perez-Hernandez, N., Granados, J., et al. Comparative Study of the Residues 63 and 67 on the HLA-B Molecule in Patients with Takayasu’s Arteritis. Immunology Letters, 96, 225-229.

[27]   Yoshida, M., Kimura, A., Katsuragi, K., Numano, F. and Sasazuki, T. (1993) DNA Typing of HLA-B Gene in Takayasu’s Arteritis. Tissue Antigens, 42, 87-90.

[28]   Bertipaglia, B., Faggin, E., Cillo, U., Zanus, G., Angelini, A. and Pauletto, P. (2004) Is Apoptosis of Vascular Smooth Muscle Cells Involved in the Development of Takayasu Arteritis? Suggestions from a Case Report. Rheumatology, 44, 484-487.

[29]   Seko, Y., Sugishita, K., Sato, O., Takagi, A., Tada, Y., Matsuo, H., et al. (2004) Expression of Costimulatory Molecules (4-1BBL and Fas) and Major Histocompatibility Class I Chain-Related A (MICA) in Aortic Tissue with Takayasu’s Arteritis. Journal of Vascular Research, 41, 84-90.

[30]   Vinay, D.S. and Kwon, B.S. (1998) Role of 4-1BB in Immune Responses. Seminars in Immunology, 10, 481-489.

[31]   Hoffman, G.S., Merkel, P.A., Brasington, R.D., Lenschow, D.J. and Liang, P. (2004) Anti-Tumor Necrosis Factor Therapy in Patients with Difficult to Treat Takayasu Arteritis. Arthritis & Rheumatism, 50, 2296-2304.

[32]   Molloy, E.S., Langford, C.A., Clark, T.M., Gota, C.E. and Hoffman, G.S. (2008) Anti-Tumour Necrosis Factor Therapy in Patients with Refractory Takayasu Arteritis: Long-Term Follow-Up. Annals of the Rheumatic Diseases, 67, 1567- 1569.

[33]   Quartuccio, L., Schiavon, F., Zuliani, F., Carraro, V., Catarsi, E., Tavoni, A.G., et al. (2012) Long-Term Efficacy and Improvement of Health-Related Quality of Life in Patients with Takayasu’s Arteritis Treated with Infliximab. Clinical and Experimental Rheumatology, 30, 922-928.

[34]   Caltran, E., Di Colo, G., Ghigliotti, G., Capecchi, R., Catarsi, E., Puxeddu, I., Migliorini, P. and Tavoni, A. (2014) Two Takayasu Arteritis Patients Successfully Treated with Rituximab. Clinical Rheumatology, 33, 1183-1184.

[35]   Unizony, S., Arias-Urdaneta, L., Miloslavsky, E., Arvikar, S., Khosroshahi, A., Keroack, B., Stone, J.R. and Stone, J.H. (2012) Tocilizumab for the Treatment of Large-Vessel Vasculitis (Giant Cell Arteritis, Takayasu Arteritis) and Polymyalgia Rheumatica. Arthritis Care & Research, 64, 1720-1729.

[36]   Clifford, A. and Hoffman, G.S. (2014) Recent advances in the Medical Management of Takayasu Arteritis: An Update on Use of Biologic Therapies. Current Opinion in Rheumatology, 26, 7-15.

[37]   Abisror, N., Mekinian, A., Lavigne, C., Vandenhende, M.A., Soussan, M. and Fain, O. (2013) Tocilizumab in Refractory Takayasu Arteritis: A Case Series and Updated Literature Review. Autoimmunity Reviews, 12, 1143-1149.