WJV  Vol.5 No.4 , November 2015
Serum Antibody Titers of Measles and Rubella among Japanese Children
Abstract: Background: The rubella outbreak in Japan has not yet been eliminated. In particular, an outbreak of congenital rubella syndrome has recently become a public health problem in Japan. The World Health Organization has set an elimination target of 2015 for measles in Japan. However, an outbreak of measles occurred in Japan between 2007 and 2008. Starting in April 2006, the measles and rubella vaccines were administered twice, once when a child reached 1 year old and once when the child was 5 - 6 years old (just before starting elementary school). Between October of 1978 and 2006, children were vaccinated only once for measles and rubella. Design: During the study enrollment period (2011-2013), the serum antibody titers of measles and rubella were measured in pediatric patients (n = 163) in the Tokyo Takanawa Hospital. Results: The prevalence rates of the two diseases indicated that only one vaccination was insufficient to protect against infection. Conclusions: Our studies have determined that it was important to vaccinate children twice for measles and rubella during early infancy.
Cite this paper: Tsuji, Y. and Karasawa, C. (2015) Serum Antibody Titers of Measles and Rubella among Japanese Children. World Journal of Vaccines, 5, 149-154. doi: 10.4236/wjv.2015.54017.

[1]   Tan, P., Jacobson, R.M., Poland, G.A., et al. (2001) Twin Studies of Immunogenicity-Determining the Genetic Contribution to Vaccine Failure. Vaccine, 19, 2434-2439.


[3]   Chen, R.T., Markowitz, L.E., Albrecht, P., et al. (1990) Measles Antibody: Re-Evaluation of Protective Titers. Journal of Infectious Diseases, 162, 1036-1042.

[4]   Vitek, C.R., Aduddel, M., Brinton, M.J., et al. (1999) Increased Protections during a Measles Outbreak of Children Previously Vaccinated with a Second Dose of Measles-Mumps-Rubella Vaccine. The Pediatric Infectious Disease Journal, 18, 620-623.

[5]   Hennessey, K.A., Ion-Nedelcu, N., Craciun, M., et al. (1999) Measles Epidemic in Romania, 1996-1998: Assessment of Vaccine Effectiveness by Case-Control and Cohort Studies. American Journal of Epidemiology, 150, 1250-1257.

[6]   Pebody, R.G., Gay, N.J., Hesketh, L.M., et al. (2002) Immunogenicity of Second Dose Measles-Mumps-Rubella (MMR) Vaccine and Implications for Serosurveillance. Vaccine, 20, 1134-1140.

[7]   Tabatabaei, S.R., Esteghamati, A.R., Shiva, F., Fallah, F., Radmanesh, R., Abdinia, B., Shamshiri, A.R., Khairkhaha, M., Ebrahimabad, H.S. and Karimi, A. (2013) Detection of Serum Antibodies against Measles, Mumps and Rubella after Primary Measles, Mumps and Rubella (MMR) Vaccination in Children. Archive of Iranian Medicine, 16, 38-41.

[8]   LeBaron, C.W., Forghani, B., Matter, L., Reef, S.E., Beck, C., Bi, D., Cossen, C. and Sullivan, B.J. (2009) Persistence of Rubella Antibodies after 2 Doses of Measles-Mumps-Rubella Vaccine. Journal of Infectious Diseases, 200, 888-899.

[9]   Paunio, M., Peltona, H., Valle, M., et al. (1999) Twice Vaccinated Recipients Are Better Protected against Epidemic Measles than Are Single Dose Recipients of Measles Containing Vaccine. Journal of Epidemiology and Community Health, 63, 173-178.