Health  Vol.7 No.10 , October 2015
Activity of Salivary 11β-Hydroxysteroid Dehydrogenase Type 2 Becomes the Index for the Continuous Strength Exercise to Prevent Locomotive Syndrome in Japan
ABSTRACT
The Japanese Orthopedic Association proposed a concept called locomotive syndrome (LS) to identify middle-aged and older adults at high risk of requiring health care services because of problems with locomotion-associated lower muscle mass. To prevent LS, it is important to increase muscle mass and muscle strength in middle-age by continuous resistance training. A total of 38 men and women were assessed at baseline and 6 months. Body composition, physical strength and salivary cortisol and cortisone were analyzed. The exercise intervention program was performed by individual muscle endurance level. Body weight, muscle weight and basal metabolism were increased after exercise intervention. The 30-second sit-up test and 3-minute walking were increased, and the 10-time sit-to-stand was decreased significantly. This may be related to increase of leg and abdominal muscular strength. The exercise intervention program increased salivary 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activities significantly. These results suggested that 11β-HDS2 became the index for the increase of muscular strength to prevent LS.

Cite this paper
Hasegawa, N. , Ohara, M. and Mochizuki, M. (2015) Activity of Salivary 11β-Hydroxysteroid Dehydrogenase Type 2 Becomes the Index for the Continuous Strength Exercise to Prevent Locomotive Syndrome in Japan. Health, 7, 1352-1356. doi: 10.4236/health.2015.710149.
References
[1]   Japanese Orthopedic Association (2010) Guidebook on Locomotive Syndrome. Bunkodo, Tokyo. (In Japanese)

[2]   Nakamura, K. (2008) A “Super-Aged” Society and the “Locomotive Syndrome”. Journal of Orthopaedic Science, 13, 1-2.

[3]   Japanese Orthopedic Association (2013) Locomotive Syndrome Pamphlet.
https://locomojoa.jp/en/index.pdf

[4]   Matsui, Y., Takemura, M., Harada, A., Ando, F. and Shimokata, H. (2013) Utility of “Loco-Check,” Self-Checklist For “Locomotive Syndrome” as a Tool for Estimating the Physical Dysfunction of Elderly People. Health, 5, 97-102.

[5]   Gatti, R. and De Palo, E.F. (2011) An Update: Salivary Hormones and Physical Exercise. Scand. Journal of Science and Medicine in Sport, 21, 157-169.

[6]   Frodl, T. and O’kaeane, V. (2013) How Does the Brain Deal with Cumulative Stress? A Review with Focus on Developmental Stress, HPA Axis Function and Hippocampal Structure in Human. Neurobiology of Disease, 52, 24-37.
http://dx.doi.org/10.1016/j.nbd.2012.03.012

[7]   Quinkler, M. and Stewart, P.M. (2003) Hypertension and the Cortisol-Cortisone Shuttle. The Journal of Clinical Endocrinology & Metabolism, 88, 2384-2392.
http://dx.doi.org/10.1210/jc.2003-030138

[8]   Hassan-Smith, Z.K., Morgan, S.A., Sherlock, M., Hughes, B., Taylor, A.E, Lavery, G.G, Tomlinson, J.W. and Stewart, P.M. (2015) Gender-Specific Differences in Skeletal Muscle 11β-HSD1 Expression across Healthy Aging. The Journal of Clinical Endocrinology & Metabolism, 100, 2673-2681.
http://dx.doi.org/10.1210/jc.2015-1516

[9]   Dovio, A., Roveda, E., Sciolla, C., Montaruli, A., Raffaelli, A., Saba, A., Calogiuri, G., De Frabcua, S., Borrione, P., Salvadori, P., Carandente, F. and Angeli, A. (2010) Intense Physical Exercise Increases Systemic 11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Healthy Adult Subjects. European Journal of Applied Physiology, 108, 681-687.
http://dx.doi.org/10.1007/s00421-009-1265-5

[10]   Perogamvros, I., Keevil, B.G., Ray, D.W. and Trainer, P.J. (2010) Salivary Cortisone Is A Potential Biomarker for Serum Free Cortisol. The Journal of Clinical Endocrinology & Metabolism, 95, 4951-4958.
http://dx.doi.org/10.1210/jc.2010-1215

[11]   La Marca-Ghaemmaghami, P., La Marca, R., Dainese, S.M., Haller, M., Zimmermann, R. and Ehlert, U. (2013) The Association between Perceived Emotional Support, Maternal Mood, Salivary Cortison, Salivary Cortisone, and the Ratio between the Two Compounds in Response to Acute Stress in Second Trimester Pregnant Women. Journal of Psychosomatic Research, 75, 314-320.
http://dx.doi.org/10.1016/j.jpsychores.2013.08.010

[12]   Seidman, D.S., Dolev, E., Deuster, P.A., Burstein, R., Arnon, R. and Epstein, Y. (1990) Androgenic Response to Long-Term Physical Training in Male Subjects. International Journal of Sports Medicine, 11, 421-424.
http://dx.doi.org/10.1055/s-2007-1024831

[13]   Tabata, I., Atomi, Y., Mutoh, Y. and Miyashita, M. (1990) Effect of Physical Training on the Responses of Serum Adrenocorticotropic Hormone during Prolonged Exhausting Exercise. European Journal of Applied Physiology and Occupational Physiology, 61, 188-192.
http://dx.doi.org/10.1007/BF00357597

[14]   Filaire, E., Duché, P., Lac, G. and Robert, A. (1996) Saliva Cortisol, Physical Exercise and Training: Influences of Swimming and Handball on Cortisol Concentrations in Women. European Journal of Applied Physiology and Occupational Physiology, 74, 274-278.
http://dx.doi.org/10.1007/BF00377450

 
 
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