OJBD  Vol.5 No.4 , December 2015
Factor XII (Hageman Factor) Deficiency: A Very Rare Coagulation Disorder
ABSTRACT
Background: Factor XII (Hageman Factor) is the initiating factor for the Intrinsic Pathway of Coagulation. Very low levels of Factor XII have been associated with increased levels of activated Partial Thromboplastin Time (aPTT). Association of Factor XII deficiency is more with thromboembolic disorders rather than bleeding tendencies. Aim: To learn more about the relationship of factor XII (Hageman Factor) deficiency and high levels of activated Partial Thromboplastin Time. Case Presentation: The Patient was admitted with complains of recurrent headaches and loin pain. Patient was incidentally found to have prolonged activated Partial Thromboplastin Time. This led to investigations which ultimately provided the evidence of severely low levels of Hageman Factor. Conclusion: Hageman Factor deficiency causes prolonged activated Partial Thromboplastin Time. However, most of the patients are asymptomatic for many years despite Hageman Factor deficiency.

Cite this paper
Azaad, M. , Zhang, Q. and Li, Y. (2015) Factor XII (Hageman Factor) Deficiency: A Very Rare Coagulation Disorder. Open Journal of Blood Diseases, 5, 39-42. doi: 10.4236/ojbd.2015.54006.
References
[1]   Rygal, P. and Kuc, A. (2012) Perioperative Management of Cardiac Surgery Patients with Factor XII Deficiency—Two Case Reports. Anesthesiology Intensive Therapy, 44, 217-220.

[2]   Mariano, M.L.,Yadira, P., Ana, A., Manuel, L. and Lopez Galvez, J.J. (2011) Coagulation Factor XII Congenital Deficiency in Women with Recurrent Miscarriage. International Journal of Clinical Medicine, 2, 469-472

[3]   Ozgu-Erdinc, A.S., Togrul, C., Aktulay, A., Buyukkagnici, U., Yapar Eyi, E.G. and Erkaya, S. (2014) Factor XII (Hageman) Levels in Women with Recurrent Pregnancy Loss. Journal of Pregnancy, 2014, Article ID: 459192

[4]   Ganguli, P., Rigvardhan and Kotwal, J. (2015) Thrombosis: Presentation of a Factor XII Deficiency in 10 Months Old Child—A Rare Case. International Journal of Advances in Case Reports, 2, 708-710.

[5]   Ratnoff, O.D. and Margolius Jr., A. (1955) Hageman Trait: An Asymptomatic Disorder of Blood Coagulation. Transactions of the Association of American Physicians, 68, 149-54.

[6]   Schmaier, A.H. (2008) The Elusive Physiologic Role of Factor XII. Journal of Clinical Investigation, 118, 3006-3009. http://dx.doi.org/10.1172/jci36617

[7]   Wang, Y., Wang, Z., Li, H., Bi, K. and Zhu, C. (2014) Essential Thrombocytosis Accompanied by Coagulation Factor XII Deficiency: A Case Report. International Journal of Clinical and Experimental Medicine, 7, 3725-3729.

[8]   Nizamoglu, M., Alexander, K.S., Anwar, U. and Bhandari, S. (2014) Isolated APTT Prolongation—Not Always a Bleeding Risk in Acute Paediatric Burns Surgery. European Journal of Plastic Surgery, 37, 695-696. http://dx.doi.org/10.1007/s00238-014-1012-y

[9]   Renné, T., Schmaier, A.H., Nickel, K.F., Blombäck, M. and Maas, C. (2012) In Vivo Roles of Factor XII. Blood, 120, 4296-4303. http://dx.doi.org/10.1182/blood-2012-07-292094

 
 
Top