Lack of Association between Polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 Sites of FGFR2 Gene with Breast Cancer in the Population of Kazakhstan
Author(s)
Timur S. Balmukhanov*,
Alexandra K. Khanseitova,
Victoria G. Nigmatova,
Alena S. Neupokoeva,
Daria A. Sharafutdinova,
Nagima A. Aitkhozhina
ABSTRACT
Worldwide, breast cancer (BC) is the most common invasive cancer in women. Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase receptor that is a member of the family of individually distinct fibroblast growth factor receptors involved in tumorigenesis. FGFR2 gene is amplified and over expressed in breast cancer (1 - 3). The aim of the study was to determine whether polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in FGFR2 gene are associated with breast cancer susceptibility in the population of Kazakhstan. The statistically significant associations between SNPs analyzed and breast cancer risk according χ2 and p < 0.05 criterions were not evaluated. The information describing the association of SNPs in FGFR2 with BC risk in the world populations could not be unambiguously used for Kazakhstan population.
Worldwide, breast cancer (BC) is the most common invasive cancer in women. Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase receptor that is a member of the family of individually distinct fibroblast growth factor receptors involved in tumorigenesis. FGFR2 gene is amplified and over expressed in breast cancer (1 - 3). The aim of the study was to determine whether polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in FGFR2 gene are associated with breast cancer susceptibility in the population of Kazakhstan. The statistically significant associations between SNPs analyzed and breast cancer risk according χ2 and p < 0.05 criterions were not evaluated. The information describing the association of SNPs in FGFR2 with BC risk in the world populations could not be unambiguously used for Kazakhstan population.
KEYWORDS
Fibroblast Growth Factor Receptor 2 (FGFR2), Single Nucleotide Polymorphism (SNP), Association, Breast Cancer (BC), Kazakhstan
Fibroblast Growth Factor Receptor 2 (FGFR2), Single Nucleotide Polymorphism (SNP), Association, Breast Cancer (BC), Kazakhstan
Cite this paper
Balmukhanov, T. , Khanseitova, A. , Nigmatova, V. , Neupokoeva, A. , Sharafutdinova, D. and Aitkhozhina, N. (2015) Lack of Association between Polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 Sites of FGFR2 Gene with Breast Cancer in the Population of Kazakhstan. Advances in Breast Cancer Research, 4, 109-113. doi: 10.4236/abcr.2015.44012.
Balmukhanov, T. , Khanseitova, A. , Nigmatova, V. , Neupokoeva, A. , Sharafutdinova, D. and Aitkhozhina, N. (2015) Lack of Association between Polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 Sites of FGFR2 Gene with Breast Cancer in the Population of Kazakhstan. Advances in Breast Cancer Research, 4, 109-113. doi: 10.4236/abcr.2015.44012.
References
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[1] Grose, R. and Dickson, C. (2005) Fibroblast Growth Factor Signaling in Tumorigenesis. Cytokine & Growth Factor Reviews, 16, 179-186.
http://dx.doi.org/10.1016/j.cytogfr.2005.01.003 [2] Moffa, A.B. and Ethier, S.P. (2007) Differential Signal Transduction of Alternatively Spliced FGFR2 Variants Expressed in Human Mammary Epithelial Cells. Journal of Cellular Physiology, 210, 720-731.
http://dx.doi.org/10.1002/jcp.20880 [3] Moffa, A.B., Tannheimer, S.L. and Ethier, S.P. (2004) Transforming Potential of Alternatively Spliced Variants of Fibroblast Growth Factor Receptor 2 in Human Mammary Epithelial Cells. Molecular Cancer Research, 2, 643-652. [4] Wang, H., Yang, Z. and Zhang, H. (2013) Assessing Interaction between the Associations of Fibroblast Growth Receptor 2 Common Gene Variants and Hormone Receptor Status with Breast Cancer Risk. Breast Cancer Research and Treatment, 137, 511-522.
http://dx.doi.org/10.1007/s10549-012-2343-7 [5] Raskin, L., Pinchev, M., Arad, C., Lejbkowicz, F., Tamir, A., Rennert, H.S., Rennert, G. and Gruber, S.G. (2008) FGFR2 Is a Breast Cancer Susceptibility Gene in Jewish and Arab Israeli Populations. Cancer Epidemiology, Biomarkers & Prevention, 17, 1060-1065.
http://dx.doi.org/10.1158/1055-9965.EPI-08-0018 [6] Agency of the Republic of Kazakhstan on Statistics Data. (2013)
http://www.stat.gov.kz [7] Cherdyntseva, N.V., Denisov, E.V., Litvakov, N.V., Maksimov, V.N., Malinovskaya, E.A., Babyshkina, N.N., Slonimskaya, E.M., Voevoda, M.L. and Choinzonov, E.L. (2012) Crosstalk between the FGFR2 and TP53 Genes in Breast Cancer: Data from an Association Study and Epistatic Interaction Analysis. DNA and Cell Biology, 31, 306-311.
http://dx.doi.org/10.1089/dna.2011.1351 [8] Boyarskikh, A.U., Zarubina, N.A., Biltueva, J.A., Sinkina, T.V., Voronina, E.N., Lazarev, A.F., Petrova, V.D., Aulchenko, Y.S. and Filipenko, M.L. (2009) Association of FGFR2 Gene Polymorphisms with the Risk of Breast Cancer In Population of West Siberia. European Journal of Human Genetics, 17, 1688-1691. [9] Gorodnova, T.V., Kuligina, E.Sh., Yanus, G.A., Katanugina, A.S., Abysheva, S.N., Toqo, A.V. and Imvanitov, E.N. (2010) Distribution of FGFR2, MAP3K1, LSP1, and 8q24 Alleles in Genetically Enriched Breast Cancer Patients versus Elderly Tumor-Free Women. Cancer Genetics and Cytogenetics, 199, 69-72.
http://dx.doi.org/10.1016/j.cancergencyto.2010.01.020 [10] http://bioinfo.ut.ee/primer3-0.4.0/ [11] http://www.ensembl.org [12] http://www.danielsoper.com/statcalc3