1 Case Clinical Report of Cranium Aggressive Fibromatosis and Literature Review
Affiliation(s)
1 No. 2 Neurosurgery Department, 1st Affiliated Hospital of Kunming Medical University, Yunnan, China. 2 Neuroscience Institute of Kunming Medical University, Yunnan, China.
1 No. 2 Neurosurgery Department, 1st Affiliated Hospital of Kunming Medical University, Yunnan, China. 2 Neuroscience Institute of Kunming Medical University, Yunnan, China.
ABSTRACT
Objective: The purpose of this study is to explore the clinical characteristics and therapeutic methods of aggressive fibromatosis (AF) in skull. Methods: The clinical data and operative therapy of one case of aggressive fibromatosis in skull in our department were examined and reviewed. The associated literatures were reviewed and discussed. Results: It was indicated that the main manifestation of AF in skull was headache and skull tumor. There was prominent osteolytic destruction found in X-ray plain film for skull AF. And CT scanning showed that skull sclerotin was disorganized and inhomogeneous, with widen diploe. The skull fibromatosis constituted by fibroblasts and myofibroblas, which were mainly spindle-shaped without heteromorphism. Immunohistochemistry showed positive expression of β-catenin and Vim in these cells. The enlarged incision was adopted for the strategy of operation in this patient of skull AF. After follow-up, there was no recurrence of AF discovered. Conclusions: Skull AF is very rare in neurosurgical clinic. The clinical manifestation and iconography of AF were lack of specificity. Therefore, skull AF is hard to diagnose preoperatively. The effective diagnose is mainly dependant on histopathologic examination. As for treatment, operation is the most optimal method so far, which has a good therapeutic effect.
Objective: The purpose of this study is to explore the clinical characteristics and therapeutic methods of aggressive fibromatosis (AF) in skull. Methods: The clinical data and operative therapy of one case of aggressive fibromatosis in skull in our department were examined and reviewed. The associated literatures were reviewed and discussed. Results: It was indicated that the main manifestation of AF in skull was headache and skull tumor. There was prominent osteolytic destruction found in X-ray plain film for skull AF. And CT scanning showed that skull sclerotin was disorganized and inhomogeneous, with widen diploe. The skull fibromatosis constituted by fibroblasts and myofibroblas, which were mainly spindle-shaped without heteromorphism. Immunohistochemistry showed positive expression of β-catenin and Vim in these cells. The enlarged incision was adopted for the strategy of operation in this patient of skull AF. After follow-up, there was no recurrence of AF discovered. Conclusions: Skull AF is very rare in neurosurgical clinic. The clinical manifestation and iconography of AF were lack of specificity. Therefore, skull AF is hard to diagnose preoperatively. The effective diagnose is mainly dependant on histopathologic examination. As for treatment, operation is the most optimal method so far, which has a good therapeutic effect.
Cite this paper
Yan, Q. , Li, M. and Li, J. (2015) 1 Case Clinical Report of Cranium Aggressive Fibromatosis and Literature Review. International Journal of Clinical Medicine, 6, 734-739. doi: 10.4236/ijcm.2015.610098.
Yan, Q. , Li, M. and Li, J. (2015) 1 Case Clinical Report of Cranium Aggressive Fibromatosis and Literature Review. International Journal of Clinical Medicine, 6, 734-739. doi: 10.4236/ijcm.2015.610098.
References
[1] Gardini, G., Mingthetti, G. and Ferracini, R. (1978) Desmoplastic Fibroma of Frontal Bone: Report of a Case (Author’s Transl). Pathologica, 70, 575-579. [2] Rabin, D., Ang, L.C., Megyesi, J., et al. (2003) Desmoplastic Fibroma of the Cranium: Case Report and Review of the Literature. Neurosurgery, 52, 950-954.
http://dx.doi.org/10.1227/01.NEU.0000053025.36216.3C [3] Fletcher, C.D.M., Unni, K.K. and Mertens, F. (2002) World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Soft Tissue and Bone. IARC Press, Lyon, 83-84. [4] Cho, B.H., Tye, G.W., Fuller, C.E., et al. (2013) Dsmoplastic Fibroma of the Pediatric Cranium: Case Report and Review of the Literature. Child’s Nervous System, 29, 2311-2315.
http://dx.doi.org/10.1007/s00381-013-2210-9 [5] Cao, L., Zhao, L.J., Liu, N.B., et al. (2011) The Clinical Characteristics and Prognostic Factors of Aggressive Fibromatosis in 142 Patients. Chinese Journal of Radiation Oncology, 20, 138-141. [6] Huang, F.-L., Qiu, F.-B., Zhang, X.-F. and Sun, D.-W. (2013) Epidemiologic Feature and Analysis of Diagnosis and Treatment of Desmoids in Recent 20 Years in China. Shandong Medical Journal, 53, 61-63. [7] Tang, X.-P., Feng, L. and Xie, X.-Y. (2006) 1 Case Report of Skull Desmoids and Literature Review. Chinese Journal of Neurosurgery, 22, 135-137. [8] Inwards, C.Y., Unni, K.K., Beabout, J.W., et al. (1991) Desmoplastic Fibroma of Bone. Cancer, 67, 1978-1983.
http://dx.doi.org/10.1002/1097-0142(19911101)68:9<1978::AID-CNCR2820680922>3.0.CO;2-H [9] Deniz, K. and Ceylan, D. (2008) Desmoplastic Fibroma of the Skull. Acta Neurochirurgica (Wien), 150, 285-290.
http://dx.doi.org/10.1007/s00701-007-1399-3 [10] Wolfe, S.Q., Cervantes, L., Olavarria, G., et al. (2005) Desmoplastic Fibroma of the Pediatric Skull. Report of the Three Cases. Journal of Neurosurgery, 103, 362-365. [11] Fletcher, C.D.M., Unni, K.K. and Mertens, F. (2002) World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Soft Tissue and Bone. IARC Press, Lyon, 288. [12] Bhattacharya, B., Dilworth, H.P., Iacobuzio-Donahue, C., et al. (2005) Muchear Beta-Catenin Expression Distinguishes Deep Fibromatosis from Other Begign and Malignant Fibroblastic and Myofibroblastic Lesions. American Journal of Surgical Pathology, 29, 653-659.
http://dx.doi.org/10.1097/01.pas.0000157938.95785.da [13] Carlson, J.W. and Flether, C.D. (2007) Immunohistochistry for Beta-Catenin in the Differential Diagnosis and of Spindle Cell Lesions: Analysis of a Series and Review of the Literature. Histopathology, 51, 509-514.
http://dx.doi.org/10.1111/j.1365-2559.2007.02794.x [14] Chen, Y.X., Zhang, T. and Shen, D.F. (2013) Role of β-Catenin in the Diagnosis and Diffential Diagnosis of Fibromatosis. Journal of Clinical and Experimental Pathology, 29, 438-440. [15] Mammano, S., Candiotto, S. and Balsano, M. (1997) Cast and Brace Treatment of Eosinophilic Granuloma of the Spine. Journal of Pediatric Orthopedics, 17, 821-827.
http://dx.doi.org/10.1097/01241398-199711000-00023 [16] Chopra, R., Bhardwaj, M. and Premsagar, I.C. (2010) Fibrosarcoma of the Meninges. Rare Tumors, 2, e3.
http://dx.doi.org/10.4081/rt.2010.e3 [17] Haeren, R.H., Dings, J., Hoeberigs, M.C., et al. (2012) Posttraumatic Skull Hemangioma: Case Report. Journal of Neurosurgery, 117, 1082-1088.
http://dx.doi.org/10.3171/2012.8.JNS112141 [18] Feuvret, L., Noël, G., Calugaru, V., Terrier, P. and Habrand, J.L. (2005) Chondromyxoid Fibroma of the Skull Base: Differential Diagnosis and Radiotherapy: Two Case Reports and a Review of the Literature. Acta Oncologica, 44, 545-553.
http://dx.doi.org/10.1080/00365590500237846
[1] Gardini, G., Mingthetti, G. and Ferracini, R. (1978) Desmoplastic Fibroma of Frontal Bone: Report of a Case (Author’s Transl). Pathologica, 70, 575-579. [2] Rabin, D., Ang, L.C., Megyesi, J., et al. (2003) Desmoplastic Fibroma of the Cranium: Case Report and Review of the Literature. Neurosurgery, 52, 950-954.
http://dx.doi.org/10.1227/01.NEU.0000053025.36216.3C [3] Fletcher, C.D.M., Unni, K.K. and Mertens, F. (2002) World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Soft Tissue and Bone. IARC Press, Lyon, 83-84. [4] Cho, B.H., Tye, G.W., Fuller, C.E., et al. (2013) Dsmoplastic Fibroma of the Pediatric Cranium: Case Report and Review of the Literature. Child’s Nervous System, 29, 2311-2315.
http://dx.doi.org/10.1007/s00381-013-2210-9 [5] Cao, L., Zhao, L.J., Liu, N.B., et al. (2011) The Clinical Characteristics and Prognostic Factors of Aggressive Fibromatosis in 142 Patients. Chinese Journal of Radiation Oncology, 20, 138-141. [6] Huang, F.-L., Qiu, F.-B., Zhang, X.-F. and Sun, D.-W. (2013) Epidemiologic Feature and Analysis of Diagnosis and Treatment of Desmoids in Recent 20 Years in China. Shandong Medical Journal, 53, 61-63. [7] Tang, X.-P., Feng, L. and Xie, X.-Y. (2006) 1 Case Report of Skull Desmoids and Literature Review. Chinese Journal of Neurosurgery, 22, 135-137. [8] Inwards, C.Y., Unni, K.K., Beabout, J.W., et al. (1991) Desmoplastic Fibroma of Bone. Cancer, 67, 1978-1983.
http://dx.doi.org/10.1002/1097-0142(19911101)68:9<1978::AID-CNCR2820680922>3.0.CO;2-H [9] Deniz, K. and Ceylan, D. (2008) Desmoplastic Fibroma of the Skull. Acta Neurochirurgica (Wien), 150, 285-290.
http://dx.doi.org/10.1007/s00701-007-1399-3 [10] Wolfe, S.Q., Cervantes, L., Olavarria, G., et al. (2005) Desmoplastic Fibroma of the Pediatric Skull. Report of the Three Cases. Journal of Neurosurgery, 103, 362-365. [11] Fletcher, C.D.M., Unni, K.K. and Mertens, F. (2002) World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Soft Tissue and Bone. IARC Press, Lyon, 288. [12] Bhattacharya, B., Dilworth, H.P., Iacobuzio-Donahue, C., et al. (2005) Muchear Beta-Catenin Expression Distinguishes Deep Fibromatosis from Other Begign and Malignant Fibroblastic and Myofibroblastic Lesions. American Journal of Surgical Pathology, 29, 653-659.
http://dx.doi.org/10.1097/01.pas.0000157938.95785.da [13] Carlson, J.W. and Flether, C.D. (2007) Immunohistochistry for Beta-Catenin in the Differential Diagnosis and of Spindle Cell Lesions: Analysis of a Series and Review of the Literature. Histopathology, 51, 509-514.
http://dx.doi.org/10.1111/j.1365-2559.2007.02794.x [14] Chen, Y.X., Zhang, T. and Shen, D.F. (2013) Role of β-Catenin in the Diagnosis and Diffential Diagnosis of Fibromatosis. Journal of Clinical and Experimental Pathology, 29, 438-440. [15] Mammano, S., Candiotto, S. and Balsano, M. (1997) Cast and Brace Treatment of Eosinophilic Granuloma of the Spine. Journal of Pediatric Orthopedics, 17, 821-827.
http://dx.doi.org/10.1097/01241398-199711000-00023 [16] Chopra, R., Bhardwaj, M. and Premsagar, I.C. (2010) Fibrosarcoma of the Meninges. Rare Tumors, 2, e3.
http://dx.doi.org/10.4081/rt.2010.e3 [17] Haeren, R.H., Dings, J., Hoeberigs, M.C., et al. (2012) Posttraumatic Skull Hemangioma: Case Report. Journal of Neurosurgery, 117, 1082-1088.
http://dx.doi.org/10.3171/2012.8.JNS112141 [18] Feuvret, L., Noël, G., Calugaru, V., Terrier, P. and Habrand, J.L. (2005) Chondromyxoid Fibroma of the Skull Base: Differential Diagnosis and Radiotherapy: Two Case Reports and a Review of the Literature. Acta Oncologica, 44, 545-553.
http://dx.doi.org/10.1080/00365590500237846