Comparative Antibiotic Sensitivity Pattern of Hospital and Community Acquired Staphylococcus aureus Isolates of Jessore, Bangladesh
Affiliation(s)
Department of Microbiology, Jessore University of Science and Technology, Jessore, Bangladesh.
Department of Microbiology, Jessore University of Science and Technology, Jessore, Bangladesh.
ABSTRACT
Staphylococcus aureus has emerged over the past several decades as a leading cause of hospital acquired infections, which are more commonly termed as nosocomial infections. In recent years, strains of this bacterium which are resistant against several types of antibiotics have evolved and their prevalence is becoming a potential epidemiological threat. As there are limited data available on antibiotic resistance patterns of S. aureus that are isolated from hospital, the study was undertaken. The study was conducted by collecting swab samples from the hospital environment & volunteers and then identified them by standard methods. In case of hospital isolates, highest percentage of resistance was shown against Erythromycin (88.89%) and Ampicillin (83.33%). Significant resistance was also observed in cases of Ciprofloxacin (33.33%) and Tetracycline (33.33%). Lowest percentage of resistance was shown against Streptomycin (11.11%) and Vancomycin shows only intermediate resistant pattern (11.11%). On the other hand, community isolates were 100% sensitive against four antibiotics except Ampicillin (60% resistant) and Vancomycin (20% resistant). From the result it is easily discernable that, there are significant differences in the resistance pattern among hospital environment isolates and community acquired isolates. Samples were collected from different locations of hospital surgery room e.g. floor, wall, operating bed, trolley, sitting tool, cabinet etc. As anticipated, highest number of isolates showing resistance against these antibiotics were from the tool used for sitting.
Staphylococcus aureus has emerged over the past several decades as a leading cause of hospital acquired infections, which are more commonly termed as nosocomial infections. In recent years, strains of this bacterium which are resistant against several types of antibiotics have evolved and their prevalence is becoming a potential epidemiological threat. As there are limited data available on antibiotic resistance patterns of S. aureus that are isolated from hospital, the study was undertaken. The study was conducted by collecting swab samples from the hospital environment & volunteers and then identified them by standard methods. In case of hospital isolates, highest percentage of resistance was shown against Erythromycin (88.89%) and Ampicillin (83.33%). Significant resistance was also observed in cases of Ciprofloxacin (33.33%) and Tetracycline (33.33%). Lowest percentage of resistance was shown against Streptomycin (11.11%) and Vancomycin shows only intermediate resistant pattern (11.11%). On the other hand, community isolates were 100% sensitive against four antibiotics except Ampicillin (60% resistant) and Vancomycin (20% resistant). From the result it is easily discernable that, there are significant differences in the resistance pattern among hospital environment isolates and community acquired isolates. Samples were collected from different locations of hospital surgery room e.g. floor, wall, operating bed, trolley, sitting tool, cabinet etc. As anticipated, highest number of isolates showing resistance against these antibiotics were from the tool used for sitting.
Cite this paper
Roy, P. , Shaheduzzaman, M. , Sultana, N. and Jahid, I. (2015) Comparative Antibiotic Sensitivity Pattern of Hospital and Community Acquired Staphylococcus aureus Isolates of Jessore, Bangladesh. Journal of Biosciences and Medicines, 3, 17-23. doi: 10.4236/jbm.2015.310003.
Roy, P. , Shaheduzzaman, M. , Sultana, N. and Jahid, I. (2015) Comparative Antibiotic Sensitivity Pattern of Hospital and Community Acquired Staphylococcus aureus Isolates of Jessore, Bangladesh. Journal of Biosciences and Medicines, 3, 17-23. doi: 10.4236/jbm.2015.310003.
References
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http://dx.doi.org/10.1056/NEJM199404283301725 [5] Swartz, M.N. (1997) Use of Antimicrobial Agents and Drug Resistance. The New England Journal of Medicine, 337, 491-492. http://dx.doi.org/10.1056/NEJM199708143370709 [6] De Lencastre, H., Oliveira, D. and Tomasz, A. (2007) Antibiotic Resistant Staphylococcus aureus: A Paradigm of Adaptive Power. Current Opinion in Microbiology, 10, 428-435.
http://dx.doi.org/10.1016/j.mib.2007.08.003 [7] Livermore, D.M. (2000) Antibiotic Resistance in Staphylococci. International Journal of Antimicrobial Agents, 16, 3- 10. http://dx.doi.org/10.1016/S0924-8579(00)00299-5 [8] Naimi, T.S., LeDell, K.H., Como-Sabetti, K., Borchardt, S.M., Boxrud, D.J., et al. (2003) Comparison of Community- and Health Care-Associated Methicillin-Resistant Staphylococcus aureus Infection. JAMA, 290, 2976-2984. http://dx.doi.org/10.1001/jama.290.22.2976 [9] Kluytmans-VandenBergh, M. and Kluytmans, J. (2006) Community-Acquired Methicillin-Resistant Staphylococcus aureus: Current Perspectives. Clinical Microbiology and Infection, 12, 9-15.
http://dx.doi.org/10.1111/j.1469-0691.2006.01341.x [10] Adegoke, A.A. and Komolafe, A.O. (2009) Multi-Drug Resistant Staphylococcus aureus in Clinical Cases in Ile-Ife, Southwest Nigeria. International Journal of Medicine and Medical Sciences, 1, 068-072. [11] Zoumalan, R.A. and Rosenberg, D.B. (2008) Methicillin-Resistant Staphylococcus aureus-Positive Surgical Site Infections in Face-Lift Surgery. Archives of Facial Plastic Surgery, 10, 116-123.
http://dx.doi.org/10.1001/archfaci.10.2.116
[1] Kluytmans, J., Van Belkum, A. and Verbrugh, H. (1997) Nasal Carriage of Staphylococcus aureus: Epidemiology, Underlying Mechanisms, and Associated Risks. Clinical Microbiology Reviews, 10, 505-520. [2] Lowy, F.D. (1998) Staphylococcus aureus Infections. New England Journal of Medicine, 339, 520-532. http://dx.doi.org/10.1056/NEJM199808203390806 [3] Cohen, M.L. (1992) Epidemiology of Drug Resistance: Implications for a Post-Antimicrobial Era. Science, 257, 1050- 1055. http://dx.doi.org/10.1126/science.257.5073.1050 [4] Tomasz, A. (1994) Multiple-Antibiotic-Resistant Pathogenic Bacteria—A Report on the Rockefeller University Workshop. New England Journal of Medicine, 330, 1247-1251.
http://dx.doi.org/10.1056/NEJM199404283301725 [5] Swartz, M.N. (1997) Use of Antimicrobial Agents and Drug Resistance. The New England Journal of Medicine, 337, 491-492. http://dx.doi.org/10.1056/NEJM199708143370709 [6] De Lencastre, H., Oliveira, D. and Tomasz, A. (2007) Antibiotic Resistant Staphylococcus aureus: A Paradigm of Adaptive Power. Current Opinion in Microbiology, 10, 428-435.
http://dx.doi.org/10.1016/j.mib.2007.08.003 [7] Livermore, D.M. (2000) Antibiotic Resistance in Staphylococci. International Journal of Antimicrobial Agents, 16, 3- 10. http://dx.doi.org/10.1016/S0924-8579(00)00299-5 [8] Naimi, T.S., LeDell, K.H., Como-Sabetti, K., Borchardt, S.M., Boxrud, D.J., et al. (2003) Comparison of Community- and Health Care-Associated Methicillin-Resistant Staphylococcus aureus Infection. JAMA, 290, 2976-2984. http://dx.doi.org/10.1001/jama.290.22.2976 [9] Kluytmans-VandenBergh, M. and Kluytmans, J. (2006) Community-Acquired Methicillin-Resistant Staphylococcus aureus: Current Perspectives. Clinical Microbiology and Infection, 12, 9-15.
http://dx.doi.org/10.1111/j.1469-0691.2006.01341.x [10] Adegoke, A.A. and Komolafe, A.O. (2009) Multi-Drug Resistant Staphylococcus aureus in Clinical Cases in Ile-Ife, Southwest Nigeria. International Journal of Medicine and Medical Sciences, 1, 068-072. [11] Zoumalan, R.A. and Rosenberg, D.B. (2008) Methicillin-Resistant Staphylococcus aureus-Positive Surgical Site Infections in Face-Lift Surgery. Archives of Facial Plastic Surgery, 10, 116-123.
http://dx.doi.org/10.1001/archfaci.10.2.116