OJIC  Vol.5 No.4 , October 2015
Synthesis, Characterization and Antibacterial Activity of Mixed Ligand (HL) Complexes Mn(ll), Co(ll), Ni(ll), Zn(ll), Cd(ll) and Hg(ll) with Azide (N3-)
Abstract: The complexes of mixed ligand (HL) as primary ligand with azide ion (N3-) as co-ligand with Mn(ll), Co(ll), Ni(ll), Zn(ll), Cd(ll) and Hg(ll) were prepared via reaction metal (ll) chloride salt with ligand (HL) and sodium azide (NaN3) using 1:2:2 mole ratio in ethanol solvent, respectively. The complexes of mixed ligand (HL) were characterized by elemental microanalysis (C.H.N), atomic absorption chloride content, molar conductance, magnetic susceptibility, melting point, FTIR and UV-Vis spectral data. The anti bacterial activity with four kinds of bacteria, Staphylococcus aureus, Bacillus, Escherichia coli and Pseudomonas aureus was studied.
Cite this paper: Sultan, J. , Lateaf, S. and Rashid, D. (2015) Synthesis, Characterization and Antibacterial Activity of Mixed Ligand (HL) Complexes Mn(ll), Co(ll), Ni(ll), Zn(ll), Cd(ll) and Hg(ll) with Azide (N3-). Open Journal of Inorganic Chemistry, 5, 102-111. doi: 10.4236/ojic.2015.54011.

[1]   Mehta, B.H. and Chavan, V.L. (2011) X-Ray, Thermal and Biological Studies of Ru(III), Rh(III) and Pd(II) Schiff Base Metal Complexes. Research Journal of Chemistry and Environment, 15, 57-61.

[2]   Raman, N., Raja, S.J. and Salkthivel, A. (2009) Transition Metal Complexes with Schiff-Base Ligands: 4-Aminoanti-pyrine Based Derivatives—A Review. Journal of Coordination Chemistry, 62, 691-709.

[3]   Rosu, T. Pahontu, E., Maxim, C., Georgescu, R., Stanica, N. and Gulea, A. (2011) Some New Cu(II) Complexes Containing an on Donor Schiff Base: Synthesis, Characterization and Antibacterial Activity. Polyhedron, 30, 154-162.

[4]   Mohamed, G.G., Omar, M.M. and Ibrahim, A.A. (2009) Biological Activity Studies on Metal Complexes of Novel Tridentate Schiff Base Ligand. Spectroscopic and Thermal Characterization. European Journal of Medicinal Chemistry, 44, 4801-4812.

[5]   Elemike, E.E. Oviawe A.P. and Otuokere, I.E. (2011) Potentiation of the Antimicrobial Activity of 4-Benzylimino-2,3-Dimetyl-1-phenylpyrazal-5-one by Metal Chelation. Research Journal of Chemical Sciences, 1, 6-11.

[6]   Agarwal, R.K., Singh, I. and Sharma, D.K. (2006) Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes. Bioinorganic Chemistry and Applications, 2006, 1-10.

[7]   Acheson, R.M. (2009) Introduction to Heterocyclic Compounds. 4th Edition, Wiley, New York.

[8]   Gopalakrishman, S. and Joseph, J. (2009) Antifungal Activities of Copper (II) with Biosensitive Macrocyclic Shiff Base Ligands Derived from 4-Aminoantipyrien Derivatives. Microbiology, 37, 141-146.

[9]   Mishchenco, A.V. Lukov V.V. and Popov, L.D. (2011) Synthesis and Physico-Chemical Study of Complexation of Glyoxylic Acid Aroylhydrazones with Cu(II) in Solution and Solid Phase. Journal of Coordination Chemistry, 64, 1963-1976.

[10]   Kramer, D.N., Klein, N. and Baselice, R.A. (1999) Quantitative Determination of Glyoxylic Acid. Analytical Chemistry, 31, 250-252.

[11]   Sokol, H.A. (1977) Determination of Pyruvic and Glyoxylic Acids in the Presence of Acetaldehyde. Analytica Chimica Acta, 89, 407-408.

[12]   Tharmaraj, P., Kodimunthiri, D., Sheela, C.D. and Shanmugapriya, C.S. (2009) Synthesis, Spectral Studies and Antibacterial Activity of Cu(II), Co(II) and Ni(II) Complexes of 1-(2-Hydroxyphenyl)-3-phenyl-2-propen-1-one)N2-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl] Hydrazone. Journal of the Serbian Chemical Society, 74, 927-938.

[13]   Suresh, M.S. and Prakash, V. (2010) Preparation and Characterization of Cr(III), Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Chelates of Schiffs Base Derived from 4-Aminoantipyrine. International Journal of Physical Sciences, 5, 2203-2211.

[14]   Anupama, B., Padmaja, M. and Kumari, C.G. (2012) Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand. E-Journal of Chemistry, 9, 389-400.

[15]   Raman, N., Sobha, S. and Selvaganapathy, M. (2012) Probing the DNA Binding Mode of Transition Metal Based Biologically Active Compounds: Validation by Spectroscopic Methods. International Journal of Pharma and Bio Sciences, 3, 251-268.

[16]   Manjula, B. and Antony, S.A. (2013) Arsenic Induced Biochemical Changes in Perna viridis as Potential Biomarkers in Metal Pollution. Asian Journal of Biochemical and Pharmaceutical Research, 3, 168-178.

[17]   Wang, X.Y., Wang, Z.M. and Gao, S. (2008) Constructing Magnetic Molecular Solids by Employing Three-Atom Ligands as Bridges. Chemical Communications, 2008, 281-294.

[18]   Ju, Z.F., Yao, Q.X., Wu, W. and Zhang, I. (2008) Strong Electron-Accepting Methyl Viologen Dication Confined in Magnetic Hosts: Synthesis, Structural, Characterization, Change-Transfer and Magnetic Properties, of [(MV)2[Ni-(SCN)5].Cl.2H2O]n and [(MV)[M(N3)2(SCN)2]] (M=Mn, Co). Dalton Transactions, 355-362.

[19]   Belaid, S., Landreau, A., Djebbar, S., Benali-Baitich, O., Bouet, G. and Bouchara, J. (2008) Synthesis, Characterization and Antifungal Activity of a Series of Manganese(II) and Cupper(II) Complexes with Ligands Derived from Reduced N,N-O-phenylene bis(salicylideneimine). Journal of Inorganic Biochemistry, 102, 63-69.

[20]   El-Asmy, A.A., Al-Ansi, T.Y. and Shaiba, Y.M. (1989) Chelated Complexes of Cadmium(II), Cobalt(II), Copper(II), Mercury(II), Nickel(II), Uranyl(II) and Zinc(II) with Benzil bis(4-phenylthiosemicarbazone). Transition Metal Chemistry, 14, 446-452.

[21]   Socrates, G. (1980) Infrared Characteristic Group Frequencies. Wiley, New York.

[22]   Raj, K.D. and Sharad, K.M. (2011) Synthesis, Spectroscopic (IR, Electronic, Fab-Mass, and PXRD), Magnetic and Antimicrobial Studies of New Iron(III) Complexes Containing Shiff Bases and Substituted Benzoxazole Ligands. Journal of Coordination Chemistry, 64, 2292-2301.

[23]   Nakamoto, K. (1978) Infrared and Raman Spectra of Inorganic and Coordination Compounds. 3rd Edition, Wiley, New York.

[24]   Cowely, A.R. Dilworth, J.R. Donnelly, P.S. and Whilte, J.M. (2006) Copper Complexes of Thiosemicarbazone-Pyridyl-hydrazine (THYNIC) Hybrid Ligands: A New Versatile Potential Bifunctional Chelator for Copper Radiopharmaceuticals. Inorganic Chemistry, 45, 496-498.

[25]   Al-Hamdani, A.A.S. and Shaker, S.A. (2011) Synthesis, Characterization, Structural Studies and Biological Activity of a New Schiff Base-Azo Ligand and Its Complexation with Selected Metal Ions. Oriental Journal of Chemistry, 27, 835-845.

[26]   Lever, A.B.P. (1984) Inorganic Electronic Spectroscopy. 2nd Edition, Elsevier, New York.

[27]   Huheey, J.E. (1994) Inorganic Chemistry: Principles of Structure and Reactivity. Harper and Row Publisher, New York.

[28]   Awetz, J., Melnick, P. and Delbrgs, A. (2007) Medical Microbiology. 4th Edition, McGraw Hill, New York.

[29]   Priya, N.P., Arunachalam, S.V., Sathya, N., Chinnusamy, V. and Jayabalakrishnan, C. (2009) Catalytic and Antimicrobial Studies of Binuclear Ruthenium(III) Complexes, Containing Bis-β-Diketones. Transition Metal Chemistry, 34, 437-445.

[30]   Jayablakrishnan, C. and Natarajan, K. (2002) Synthesis, Characterization, and Biological Activities of Ruthenium(II) Carbonyl Complexes Containing Bifunctional Tridentate Schiff Bases. Transition Metal Chemistry, 27, 75-79.

[31]   Tweedy, B.G. (1964) Plant Extracts with Metal Ions as Potential Antimicrobial Agents. Phytopatology, 55, 910-918.