CRCM  Vol.4 No.9 , September 2015
Basal Cell Carcinoma Arising from a Follicular Hybrid Cyst
Malignant tumors arising from follicular cysts are rare. Herein, we report of a 62-year-old Japanese woman with a slowly growing tumor, 22 × 20 mm in size, located on her nose for 2 years. Histopathological examination of the surgically excised tumor showed that the tumor cells were basaloid and formed peripheral palisading patterns. The tumor contained a cystic structure in its center, and the cyst wall was lined with stratified epithelium with or without keratohyalin granules. Based on these findings, a diagnosis of basal cell carcinoma arising from a follicular hybrid cyst was made. To our knowledge, this is the first case of basal cell carcinoma originating from a follicular hybrid cyst. A review of previous reports of basal cell carcinoma from a follicular cyst indicated that the majority of previous cysts were located on the face, and that the lesions had been present for a relatively long time. The present case showed typical clinical findings and followed a regular course. Malignant transformation may be a rare event, but it can occur in a follicular cyst, so cysts and suspected cysts, especially those found on the face and those persisting for relatively long time, should always be subjected to histological examination.

Cite this paper
Aizu, T. , Kaneko, T. , Takiyoshi, N. , Minakawa, S. , Korekawa, A. , Nakano, H. and Sawamura, D. (2015) Basal Cell Carcinoma Arising from a Follicular Hybrid Cyst. Case Reports in Clinical Medicine, 4, 317-320. doi: 10.4236/crcm.2015.49063.
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