OJOG  Vol.5 No.11 , September 2015
Gastrointestinal Stromal Tumor Mimicking Ovarian Tumor
ABSTRACT
Background: Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors that may mimic ovarian tumor on presurgical testing. They are most often located in the stomach and proximal small intestine. The gross appearance of GISTs is highly variable. These tumors are usually asymptomatic, often discovered accidentally during endoscopic or radiologic examinations. Case Report: We reported a case of 55-year-old post menopausal woman who presented to us as ovarian mass which turned out to be malignant epithelioid gastrointestinal stromal tumor intraoperatively and by immunohistochemistry. Conclusion: In the patients with a pelvic mass, especially if unusual symptoms and laboratory data being not compatible with gynecological disease, the possibility of diseases other than a gynecologic disease has to be considered. Considering that only few patients with gastrointestinal stromal tumors have been reported in the obstetrical and gynecological literature, the awareness of such an entity by the obstetricians-gynecologists is necessary in order to facilitate coordinated approach with the general surgeons and oncologists for the optimal care of the patients.

Cite this paper
Kadam, P. , Dave, P. and Mankad, M. (2015) Gastrointestinal Stromal Tumor Mimicking Ovarian Tumor. Open Journal of Obstetrics and Gynecology, 5, 588-591. doi: 10.4236/ojog.2015.511083.
References
[1]   Yantiss, R.K., Rosenberg, A.E., Selig, M.K. and Nielsen, G.P. (2002) Gastrointestinal Stromal Tumors: An Ultrastructural Study. International Journal of Surgical Pathology, 10, 101-113.
http://dx.doi.org/10.1177/106689690201000203

[2]   Agaram, N.P., Besmer, P., Wong, C.C., Guo, T.H., Socci, N.D., et al. (2007) Pathologic and Molecular Heterogeneity in Imatinib-Stable or Imatinib-Responsive Gastrointestinal Stromal Tumors. Clinical Cancer Research, 13, 170-181.
http://dx.doi.org/10.1158/1078-0432.CCR-06-1508

[3]   Graadt van Roggen, J.F., van Velthuysen, M.L. and Hogendoorn, P.C. (2001) The Histopathological Differential Diagnosis of Gastrointestinal Stromal Tumours. Journal of Clinical Pathology, 54, 96-102.
http://dx.doi.org/10.1136/jcp.54.2.96

[4]   Miettinen, M. (2012) [Gastrointestinal stromal tumor]. Duodecim, 128, 1441-1450.

[5]   Miettinen, M. and Lasota, J. (2003) Gastrointestinal Stromal Tumors (GISTs): Definition, Occurrence, Pathology, Differential Diagnosis and Molecular Genetics. Polish Journal of Pathology, 54, 3-24.

[6]   Heinrich, M.C., Corless, C.L., Duensing, A., McGreevey, L., Chen, C.J., Joseph, N., Singer, S., Griffith, D.J., Haley, A., Town, A., Demetri, G.D., Fletcher, C.D. and Fletcher, J.A. (2003) PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors. Science, 299, 708-710.
http://dx.doi.org/10.1126/science.1079666

[7]   Kim, K.M., Kang, D.W., Moon, W.S., Park, J.B., Park, C.K., Sohn, J.H., Jeong, J.S., Cho, M.Y., Jin, S.Y., Choi, J.S. and Kang, D.Y. (2005) Gastrointestinal Stromal Tumor Committee; The Korean Gastrointestinal Pathology Study Group. Gastrointestinal Stromal Tumors in Koreans: Incidence and the Clinical, Pathologic and Immunohistochemical Findings. Journal of Korean Medical Science, 20, 977-984.
http://dx.doi.org/10.3346/jkms.2005.20.6.977

[8]   Motegi, A., Sakurai, S., Nakayama, H., Sano, T., Oyama, T. and Nakajima, T. (2005) PKC Theta, a Novel Immunohistochemical Marker for Gastrointestinal Stromal Tumors (GIST), Especially Useful for Identifying KIT-Negative Tumors. Pathology International, 55, 106-112.
http://dx.doi.org/10.1111/j.1440-1827.2005.01806.x

[9]   Gupta, P., Tewari, M. and Shulka, H. (2008) Gastrointestinal Stromal Tumor. Surgical Oncology, 17, 129-138.
http://dx.doi.org/10.1016/j.suronc.2007.12.002

[10]   Ma, C.K., Amin, M.B., Kintanar, E., Linden, M.D. and Zarbo, R.J. (1993) Immunohistologic Characterization of Gastrointestinal Stromal Tumors: A Study of 82 Cases Compared with 11 Cases of Leiomyomas. Modern Pathology, 6, 139-144.

[11]   Van Oosterom, A.T., Judson, I., Verweij, J., Stroobants, S., Donato di Paola, E., Dimitrijevic, S., Martens, M., Webb, A., Sciot, R., Van Glabbeke, M., Silberman, S. and Nielsen, O.S. (2001) European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. Safety and Efficacy of Imatinib (STI571) in Metastatic Gastrointestinal Stromal Tumours: A Phase I Study. The Lancet, 358, 1421-1423.

[12]   Blay, J.Y., Bonvalot, S., Casali, P., Choi, H., Debiec-Richter, M., DeiTos, A.P., et al. (2005) GIST Consensus Meeting Panelists. Consensus Meeting for the Management of Gastrointestinal Stromal Tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the Auspices of ESMO. Annals of Oncology, 16, 566-578.
http://dx.doi.org/10.1093/annonc/mdi127

[13]   Verweij, J., Casali, P.G., Zalcberg, J., LeCesne, A., Reichardt, P., et al. (2004) Progression-Free Survival in Gastrointestinal Stromal Tumours with High-Dose Imatinib: Randomised Trial. The Lancet, 364, 1127-1134.
http://dx.doi.org/10.1016/S0140-6736(04)17098-0

[14]   Joensuu, H. (2006) Gastrointestinal Stromal Tumor (GIST) Gastrointestinal Stromal Tumor (GIST). Annals of Oncology, 17, 280-286.
http://dx.doi.org/10.1093/annonc/mdl274

[15]   Blay, J.Y., Le Cesne, A., Ray-Coquard, I., Bui, B., Duffaud, F., Delbaldo, C., et al. (2007) Prospective Multicentric Randomized Phase III Study of Imatinib in Patients with Advanced Gastrointestinal Stromal Tumors Comparing Interruption versus Continuation of Treatment beyond 1 Year: The French Sarcoma Group. Journal of Clinical Oncology, 25, 1107-1113.
http://dx.doi.org/10.1200/JCO.2006.09.0183

 
 
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