WJCD  Vol.5 No.9 , September 2015
Diastolic Dysfunction and Left Ventricle Remodeling in Men with Impaired Fasting Glucose
Background: Early disturbances of carbohydrate metabolism are an independent risk factor of development of cardiovascular diseases. Objective: The diastolic dysfunction and left ventricle remodeling depending on presence of impaired fasting glucose were examined. Methods: The characteristics of heart remodeling and fasting glucose of capillary blood were studied in 85 men aged 30 to 63 years without coronary heart disease. Results: In male patients with impaired fasting glucose in comparison of persons with level of glucose less than 5.6 mM/l, more pronounced diastolic dysfunction and left ventricle remodeling associated with more often presence III degree of peripheral obesity. Conclusion: Impaired fasting glucose in men increases probability of development of heart remodeling.

Cite this paper
Kratnov, A. and Timganova, E. (2015) Diastolic Dysfunction and Left Ventricle Remodeling in Men with Impaired Fasting Glucose. World Journal of Cardiovascular Diseases, 5, 261-265. doi: 10.4236/wjcd.2015.59029.
[1]   Straka, R.J, Liu, L.Z., Girase, P.S., DeLorenzo, A. and Chapman, R.H. (2009) Incremental Cardiovascular Costs and Resource Use Associated with Diabetes: An Assessment of 29,863 Patients in the US Managed-Care Setting. Cardiovascular Diabetology, 8, 53.

[2]   The DECODE study group on behalf of the Europe an Diabetes Epidemiology Group (1999) Glucose Tolerance and Mortality: Comparison of WHO and American Diabetes Association Diagnostic Criteria. Lancet, 354, 617-621.

[3]   Vakili, B.A., Okin, P.M. and Devereux, R.B. (2001) Prognostic Implications of Left Ventricular Hypertrophy. American Heart Journal, 141, 334-341.

[4]   Galderisi, M., Anderson, K.M., Wilson, P.W. and Levy, D. (1991) Echocardiographic Evidence for the Existence of a Distinct Diabetic Cardiomyopathy (the Framingham Heart Study). American Journal Cardiology, 68, 85-89.

[5]   Chae, C.U., Glynn, R.J., Manson, J.E., Guralnik, J.M., Taylor, J.O. and Pfeer, M.A. (1998) Diabetes Predicts Congestive Heart Failure Risk in the Elderly. Circulation, 98, 721.

[6]   Miyazato, J., Horio, T., Takishita, S. and Kawano, Y. (2002) Fasting Plasma Glucose Is an Independent Determinant of Left Ventricular Diastolic Dysfunction in Nondiabetic Patients with Treated Essential Hypertension. Hypertension Research, 25, 403-439.

[7]   D’Souza, A., Howarth, F.C., Yanni, J., Dobryznski, H., Boyett, M.R., Adeghate, E., Bidasee, K.R. and Singh, J. (2011) Left Ventricle Structural Remodelling in the Prediabetic Goto-Kakizaki Rat. Experimental Physiology, 96, 875-888.

[8]   Nagueh, S.F., Appleton, C.P., Gillebert, T.C., Marino, P.N., Oh, J.K., Smiseth, O.A., Waggoner, A.D., Flachskampf, F.A., Pellikka, P.A. and Evangelista, A. (2009) Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography. European Journal of Echocardiography, 10, 165-193.

[9]   Lang, R. M., Bierig, M., Devereux, R.B., Flachskampf, F.A., Foster, E., Pellikka, P.A., Picard, M.H., Roman, M.J., Seward, J., Shanewise, J., Solomon, S., Spencer, K.T., St John, Sutton, M. and Stewart, W. (2006) Recommendations for Chamber Quantification. European Journal of Echocardiography, 7, 79-108.

[10]   Ganau, A., Devereux, R.B., Roman, M.J., de Simone, G., Pickering, T.G., Saba, P.S., Vargiu, P., Simongini, I. and Laragh, J.H. (1992) Patterns of Left Ventricular Hypertrophy and Geometric Remodeling in Essential Hypertension. Journal of the American College of Cardiology, 19, 1550-1558.

[11]   Buse, J.B., Ginsberg, H.N., Bakris, G.L., Clark, N.G., Costa, F., Eckel, R., Fonseca, V., Gerstein, H.C., Grundy, S., Nesto, R.W., Pignone, M.P., Plutzky, J., Porte, D., Redberg, R., Stitzel, K.F. and Stone, N.J. (2007) Primary Prevention of Cardiovascular Diseases in People with Diabetes Mellitus: A Scientific Statement from the American Heart Association and the American Diabetes Association. Circulation, 115, 114-126.

[12]   Qiao, Q., Lindstrom, J., Valle, T.T. and Tuomilehto, J. (2003) Progression to Clinically Diagnosed and Treated Diabetes from Impaired Glucose Tolerance and Impaired Fasting Glycaemia. Journal of British Diabetic Association, 20, 1027-1033.

[13]   De Fronzo, R.A., Ferrannini, E., Keen, H. and Zimmet, P. (2004) International Textbook of Diabetes Mellitus (Third Edition). John Wiley & Sons, Hoboken.

[14]   Romero-Corral, A., Montori, V.M., Somers, V.K., Korinek, J., Thomas, R.J., Allison, T.G., Mookadam, F. and Lopez-Jimenez, F. (2006) Association of Body-weight with Total Mortality and with Cardiovascular Events in Coronary Artery Disease: A Systematic Review of Cohort Studies. Lancet, 368, 666-678.

[15]   Haslam, D.W. and James, W.P. (2005) Obesity. Lancet, 366, 1197-1209.

[16]   Ussher, J.R. and Lopaschuk, G.D. (2006) Clinical Implications of Energetic Problems in Cardiovascular Disease. Heart and Metabolism, 32, 9-17.

[17]   Paolisso, G., Gambardella, A., Galzerano, D., D’Amore, A., Rubino, P., Verza, M., Teasuro, P., Varricchio, M. and D’Onofrio, F. (1994) Total-Body and Myocardial Substrate Oxidation in Congestive Heart Failure. Metabolism, 43, 174-178.

[18]   Boudina, S., Sena, S., Theobald, H., Sheng, X., Wright, J.J., Hu, X.X., Aziz, S., Johnson, J.I., Bugger, H., Zaha, V.G. and Abel, E.D. (2007) Mitochondrial Energetics in the Heart in Obesity-Related Diabetes: Direct Evidence for Increased Uncoupled Respiration and Activation of Uncoupling Proteins. Diabetes, 56, 2457-2466.

[19]   Chen, W.J.Y., Greulich, S., van der Meer, R.W., Rijzewijk, L.J., Lamb, H.J., de Roos, A., Smit, J.W.A., Romijn, J.A, Ruige J.B., Lammertsma, A.A., Lubberink, M., Diamant, M. and Ouwens, D.M. (2013) Activin a Is Associated with Impaired Myocardial Glucose Metabolism and Left Ventricular Remodeling in Patients with Uncomplicated Type 2 Diabetes. Cardiovascular Diabetology, 12, 150.

[20]   Blum, W.F., Englaro, P., Hanitsch, S., Juul, A., Hertel, N.T., Muller, J., Skakkebaek, N.E., Heiman, M.L., Birkett, M., Attanasio, A.M., Kiess, W. and Rascher, W. (1997) Plasma Leptin Levels in Healthy Children and Adolescents: Dependence on Body Mass Index, Body Fat Mass, Gender, Pubertal Stage and Testosterone. The Journal of Clinical Endocrinology & Metabolism, 82, 2904-2910.

[21]   Matsumura, K., Abe, I., Tsuchihashi, T. and Fujishima, M. (2000) Central Effects of Leptin on Cardiovascular and Neurohormonal Responses in Conscious Rabbits. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 278, R1314-R1320.

[22]   Francis, G.S., Goldsmith, S.R., Levine, T.B., Olivari, M.T. and Cohn, J.N. (1984) The Neurohumoral Axis in Congestive Heart Failure. Annals of Internal Medicine, 101, 370-377.