ABSTRACT It has been suggested that exposure to organic solvents may have a role in the impairment of kidney function that may progress to kidney failure. However, this has never been evaluated with an appropriate analytical study of the kidney functions of those people who are chronically exposed to these chemicals. This study was designed to measure the kidney function of car painters in the city of Makkah, Saudi Arabia. Fifty workers were selected at random for this study and compared to thirty male medical students who were taken as a control group. Blood samples were collected for the analysis of kidney function. The levels of blood urea nitrogen (BUN), creatinine, and uric acid were scientifically higher in the tested group compared to the control group. In addition to this, the levels of these parameters were significantly higher in the serum of car painters who worked in this industry for more than ten years compared to painters who worked for less than ten years. Moreover, the number of car painters who were not using protective gloves and masks during working hours were 43 and the number of car painters who visited specialized clinics because of kidney problems were 45 of the 50 tested volunteers. These findings support the hypothesized association of solvent exposure with the development of chronic renal failure. They should prompt clinicians to give greater attention to patients’ occupational exposures. Routine monitoring of kidney functions and the use of protective materials are of greater importance to minimize the occupational diseases caused by organic solvents.
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nullS. Al-Ghamdi, "Occupational Exposure to Paints Causes Impairment of Kidney Functions," Journal of Environmental Protection, Vol. 2 No. 5, 2011, pp. 533-536. doi: 10.4236/jep.2011.25061.
 T. Ehrenreich, “Renal Disease from Exposure to Solvents,” Annals of Clinical and Laboratory Science, Vol. 7, No. 1, 1977, pp. 6-16.
 Wedeen, “Occupational and Environmental Renal Disease,” Seminars in Nephrology, Vol. 17, No. 1, 1997, pp. 46-53.
 G. J. Beirne and J. T. Brennan, “Glomerulonephritis Associated with Hydrocarbon Solvents: Mediated by Antiglomerular Basement Membrane Antibody,” Arch Environ Health, Vol. 25, 1972, pp. 365-369.
 E. T. O’Brien, W. O. Yeomn and J. A. E. Hobby, “Hepatorenal Damage from Toluene in ‘Glue Sniffer’,” British Medical Journal, Vol. 2, 1971, pp. 29-30.
 S. M. Taher, R. J. Anderson, R. McCartney, M. M. Poputzer and R. W. Schirer, “Renal Tubular Acidosis Associated with Toluene ‘Sniffing’,” The New England Journal of Medicine, Vol. 290, No. 14, 1974, pp. 765-768.
 A. H. Moss, P. A. Gabow and W. D. Kahney, “Fanconi’s Syndrome and Distal Renal Tubular Acidosis after Glue Sniffing,” Annals of Internal Medicine, Vol. 92, 1980, pp. 69-70.
 H. Z. Screicher, P. A. Gabow, A. H. Moss, D. Kono and W. D. Kaehny, “Syndrome of Toluene Sniffing in Adults,” Annals of Internal Medicine, Vol. 94, 1981, pp. 758-762.
 G. Venkatamran, “Renal Damage and Glue Sniffing,” British Medical Journal, Vol. 283, No. 6304, 1981, p. 1467. doi:10.1136/bmj.283.6304.1467-a
 W. E. Daniell, W. G. Couser and L. Rosenstock, “Occupational Solvent Exposure and Glomerulonephritis: A Case Report and Review of the Literature,” Journal of the American Medical Association, Vol. 259, 1988, pp. 2280-2283. doi:10.1001/jama.259.15.2280
 C. M. Fored, G. Nise, E. Ejerblad, J. P. Fryzek, P. Lindblad, J. K. McLaughlin, C. G. Elinder and O. Nyren, “Absence of Association between Organic Solvent Exposure and Risk of Chronic Renal Failure: A Nationwide Population-Based Case-Control Study,” Journal of the American Society of Nephrology, Vol. 15, No. 1, 2004, pp. 180-186. doi:10.1097/01.ASN.0000103872.60993.06
 U. Ravnskov, “Hydrocarbons May Worsen Renal Function Inglomerulonephritis: A Meta-Analysis of the Case- Control Studies,” American Journal of Industrial Medicine, Vol. 37, No. 6, 2000, pp. 599-606.
 S. S. Al-Ghamdi, D. A. Allen, M. J. Raftery and M. M. Yaqoob, “Organic Solvent-Induced Proximal Tubular Cell Toxicity via Caspase-3 Activation,” Clinical Toxicology, Vol. 41, No. 7, 2003, pp. 941-945.
 S. S. Al-Ghamdi, M. J. Raftery and M. M. Yaqoob, “Acute Solvent Exposure Induced Activation of Cytochrome P4502E1 Causes Proximal Tubular Cell Necrosis by Oxidative Stress,” Toxicology in Vitro, Vol. 17, 2003, pp. 335-3412. doi:10.1016/S0887-2333(03)00021-3
 A.Sato, I. Yonekura, T. Kaneko and T. Koizumi, “Renal Disorders Induced by Organic Solvents,” Sangyo Igaku, Vol. 30, No. 2, 1988, pp. 85-96.
 H. Savolainen, H. Vainio, M. Helojoki and E. Elovaara, “Biochemical and Toxicological Effects of Short-Term, Intermittent Xylene Inhalation Exposure and Combined Ethanol Intake,” Archives of Toxicology, Vol. 41, No. 3, 1978, pp. 195-205. doi:10.1007/BF00354091
 R. Lauwerys, A. Bernard, C. Viau and J. P. Buchet, “Kidney Disorders and Hematotoxicity from Organic Solvent Exposure,” Scandinavian Journal of Work, Environment & Health, Vol. 11, No. 2, 1985, pp. 83-90.
 J. M. Harrington, H. Whitby, C. N. Gray, F. J. Reid, T. C. Aw and J. A. Waterhouse, “Renal Disease and Occupational Exposure to Organic Solvents: A Case Referent Approach,” British Journal of Industrial Medicine, Vol. 46, No. 9, 1989, pp. 643-50.
 S. Jacob, M. He′ry, J. C. Protois, J. Rossert and B. Stengel, “Effect of Organic Solvent Exposure on Chronic Kidney Disease Progression: The GN-progress Cohort Study,” Journal of the American Society of Nephrology, Vol. 18, No. 1, 2007, pp. 274-281.
 A. Mutti, T. Coccini, R. Alinovi, G. Toubeau, F. Broeckaert, E. Bergamaschi, P. Mozzoni, D. Nonclercq, A. Bernard and L. Manzo, “Exposure to Hydrocarbons and Renal Disease: An Experimental Animal Model,” Ren Fail, Vol. 21, 1999, pp. 369-385.
 Van Der Laan, “Chronic Glomerulonephritis and Organic Solvents. A Case-Control Study,” International Archives of Occupational and Environmental Health, Vol. 47, No. 1, 1980, pp. 1-8.
 P. Hotz, “Occupational Hydrocarbon Exposure and Chronic Nephropathy,” Toxicology, Vol. 90, No. 3, 1994, pp. 163-283. doi:10.1016/0300-483X(94)90091-4
 D. M. Hashimoto, K. T. Kelsey, T. Seitz, H. A. Feldman, B. Yakes and D. C. Christiani, “The Presence of Urinary Cellular Sediment and Albuminuria in Newspaper Pressworkers Exposed to Solvents,” Journal of Occupational and Environmental Medicine, Vol. 33, No. 4, 1991, pp. 516-26.
 G. Remuzzi and T. Bertani, “Pathophysiology of Progressive Nephropathies,” The New England Journal of Medicine, Vol. 339, 1998, pp. 1448-1456.
 D. Solet and T. G. Robins, “Renal Function in Dry Cleaning Workers Exposed to Perchloroethylene,” American Journal of Industrial Medicine, Vol. 20, No. 5, 1991, pp. 601-14. doi:10.1002/ajim.4700200504