Reem Elmaghlob¹, Gamal El Didamony¹, Ashraf Elbahrawy², Abdallah Mahmoud Abdallah², Mahmoud Haddad Hemida², Ahmed Elwassief², Mohamed Salah Ali², Ahmed Al-Ashker², Abdel-Gawad Saied Mohammad², Mohamed Hanafy Morsy³, Hafez Abdelhafeez²

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¹ Department of Microbiology and Botany, Faculty of Science, Al-Zakazik University, Al-Zakazik, Egypt.
² Department of Internal Medicine, Al-Azhar School of Medicine, Al-Azhar University, Cairo, Egypt.
³ Department of Clinical Pathology, Al-Azhar School of Medicine, Al-Azhar University, Cairo, Egypt.
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Abstract: Background: Early promotion of hepatitis B (HB) vaccination among health care workers is an important component of the HBV infection control. No available data assess immune response of HB vaccination among Egyptian medical students. Objective: we conducted this study to evaluate the immune response among medical students after completion of their vaccination schedule. Methods: A total of 150 Egyptian medical students were included. Three doses of recombinant HB vaccine had been administered to all participating students at 0, 1 and 6 months. Antibody to hepatitis B surface antigen (Anti-HBs) titers, hepatitis B surface antigen (HBsAg), and total antibody to hepatitis B core antigen (anti-HBc) were measured by enzyme immunoassay, 1 to 2 months after completion of vaccination course. Results: Among 150 students included, the mean age was 22.4 ± 1.7 years (range 18 - 28 years). Fifty nine (39.4%) were males and 91 (60.6%) were females. All students have anti-HBs levels more than 100 IU/L. The mean anti-HBs of included students was 8994.2 ± 6373.1 IU/L. There was no significant difference of anti-HBs levels regarding age, sex, residence or body mass index distribution. Conclusion: Early HB vaccination of health care workers is associated with good immune response and should be encouraged.

Keywords: HBV, HB Vaccine, Medical Students, Anti-HBs, Egypt

Cite this paper: Elmaghlob, R. , Didamony, G. , Elbahrawy, A. , Abdallah, A. , Hemida, M. , Elwassief, A. , Ali, M. , Al-Ashker, A. , Mohammad, A. , Morsy, M. and Abdelhafeez, H. (2015) Immune Response after Hepatitis B Vaccination among Egyptian Medical Students in Nile Delta. World Journal of Vaccines, 5, 140-146. doi: 10.4236/wjv.2015.53015.

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