Andrews NC, “Disorders of iron metabolism,” N Engl J Med, Vol. 341, December 1999, pp. 1986-1995.
 Kushner JP, Porter JP, and Olivieri NF, “Secondary iron overload,” Hematology Am Soc Hematol Educ Program, 2001, pp. 47-61.
 Takatoku M, Uchiyama T, Okamoto S, Kanakura Y, Sawada K, Tomonaga M, Nakao S, Nakahata T, Harada M, Murate T, and Ozawa K, and Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes, “Retrospective nationwide survey of Japanese patients with transfusion-dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality,” Eur J Haematol, Jun, 2007, Vol. 7, pp. 487-94.
 Shander A and Sazama K, “Clinical consequences of iron overload from chronic red blood cell transfusions, its diagnosis, and its management by chelation therapy,” Transfusion, May 2010, vol 50, pp. 1144-1155.
 Malcovati L, “Impact of transfusion dependency and secondary iron overload on the survival of patients with myelodysplastic syndromes,” Leuk Res, December 2007, Vol. 31, Suppl 3, S2-6.
 Oliva EN, Ronco F, Marino A, Alati C, Praticò G and Nobile F, “Iron chelation therapy associated with improvement of hematopoiesis in transfusion-dependent patients,” Transfusion, July 2010, vol 50, pp. 1568-1570.
 Giardina PJ and Grady RW, “Chelation therapy in beta-thalassemia: the benefits and limitations of desferrioxamine,” Semin Hematol, October 1995, Vol. 32, pp. 304-312.
 Gabutti V and Piga A, “Results of long-term iron-chelating therapy,”Acta Haematol, 1996, Vol. 95, pp. 26-36.
 Cappellini MD, Cohen A, Piga A, Bejaoui M, Perrotta S, Agaoglu L, Aydinok Y, Kattamis A, Kilinc Y, Porter J, Capra M, Galanello R, Fattoum S, Drelichman G, Magnano C, Verissimo M, Athanassiou-Metaxa M, Giardina P, Kourakli-Symeonidis A, Janka-Schaub G, Coates T, Vermylen C, Olivieri N, Thuret I, Opitz H, Ressayre-Djaffer C, Marks P and Alberti D, “A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia,” Blood, May 2006, Vol. 107, pp. 3455-3462.
 Porter J, Galanello R, Saglio G, Neufeld EJ, Vichinsky E, Cappellini MD, Olivieri N, Piga A, Cunningham MJ, Soulières D, Gattermann N, Tchernia G, Maertens J, Giardina P, Kwiatkowski J, Quarta G, Jeng M, Forni GL, Stadler M, Cario H, Debusscher L, Della Porta M, Cazzola M, Greenberg P, Alimena G, Rabault B, Gathmann I, Ford JM, Alberti D and Rose C, “Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study,” Eur J
 Gattermann N, Finelli C, Porta MD, Fenaux P, Ganser A, Guerci-Bresler A, Schmid M, Taylor K, Vassilieff D, Habr D, Domokos G, Roubert B and Rose C; EPIC study investigators, “Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study,” Leuk Res September 2010, Vol. 34, pp. 1143-1150.
 Wimazal F, Nosslinger T, Baumgartner C, Sperr WR, Pfeilstocker M and Valent P, “Deferasirox induces regression of iron overload in patients with myelodysplastic syndromes,” Eur J Clin Invest, May 2009, Vol. 39, pp. 406-411.
 List AF, Baer MR, Steensma D, Raza A, Esposito J and Virkus J, “Iron chelation with deferasirox (Exjade?) improves iron burden in patients with myelodysplastic syndromes (MDS),” Blood, 2008, 112, abst 634.
 Bennett JM, “Consensus statement on iron overload in myelodysplastic syndromes,” Am J Hematol, November 2008, Vol. 83, pp. 858-861.
 Suzuki T, Tomonaga M, Miyazaki Y, Nakao S, Ohyashiki K, Matsumura I, Kohgo Y, Niitsu Y, Kojima S and Ozawa K, “Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes,” Int J Hematol, July 2008, Vol. 88, pp. 30-35.
 National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology v.1, “Myelodysplastic Syndromes; 2009,” Available at:
 Miyazawa K, Ohyashiki K, Urabe A, Hata T, Nakao S, Ozawa K, Ishikawa T, Kato J, Tatsumi Y, Mori H, Kondo M, Taniguchi J, Tanii H, Rojkjaer L and Omine M, “A safety, pharmacokinetic and pharmacodynamic investigation of deferasirox (Exjade, ICL670) in patients with transfusion-dependent anemias and iron-overload: a Phase I study in Japan, “Int J Hematol, July 2008, Vol. 88, pp. 73-81.
 Taher A, El-Beshlawy A, Elalfy MS, Al Zir K, Daar S, Habr D, Kriemler-Krahn U, Hmissi A and Al Jefri A, “Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia: the ESCALATOR study,” Eur J Haematol, Jun 2009, Vol. 82, pp. 458-465.
 Cappellini MD, Porter J, El-Beshlawy A, Li CK, Seymour JF, Elalfy M, Gattermann N, Giraudier S, Lee JW, Chan LL, Lin KH, Rose C, Taher A, Thein SL, Viprakasit V, Habr D, Domokos G, Roubert B and Kattamis A; EPIC Study Investigators, “Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias,” Haematologica April 2010, Vol. 95, pp. 557- 566.
 Bennett JM, “Consensus statement on iron overload in myelodysplastic syndromes,” Am J Hematol, November 2008, Vol. 83, pp. 858-61.
 Boelaert JR, Van Cutsem J, de Locht M, Schneider YJ and Crichton RR, “Deferoxamine augments growth and pathogenicity of Rhizopus, while hydroxypyridinone chelators have no effect,” Kidney Int, March 1994, Vol. 45, pp. 667-671.
 Keberle H, “The biochemistry of desferrioxamine and its relation to iron metabolism,” Ann N Y Acad Sci, October 1964, Vol. 119, pp. 758-768.
 Boelaert JR, de Locht M, Van Cutsem J, Kerrels V, Cantinieaux B, Verdonck A, Van Landuyt HW and Schneider YJ, “Mucormycosis during deferoxamine the- rapy is a siderophore-mediated infection. In vitro and in vivo animal studies,” J Clin Invest, May 1993, Vol. 91, pp. 1979-1986.