JBM  Vol.3 No.8 , August 2015
Spectrophotometric Data in Human Immunodeficiency Virus (HIV)-Antiretroviral Drug Coated Blood Interactions
ABSTRACT
The spectrophotometric data in the interactions between the Human immunodeficiency virus (HIV) and blood cells treated with antiretroviral drug were collected to be used to show the effects of antiretroviral drugs on the absorbance characteristics of HIV infected and uninfected blood. The methodology involved the serial dilution of the five different antiretroviral drugs (two HAART/FDC and three single drugs) and the subsequent incubation with the blood samples collected from ten HIV infected persons who had not yet commenced treatment with the antiretroviral drugs, ten HIV infected persons who had already commenced treatment with the antiretroviral drugs, and ten HIV negative persons, for the absorbance measurements using a digital Ultraviolet Visible MetaSpecAE1405031Pro Spectrophotometer. The peak absorbance data for various interacting systems were measured. These were used to show that the antiretroviral drug had the effect of increasing the peak absorbance values of both the uninfected and infected blood components, i.e., the drugs were made able to increase the light absorption capacity of the blood cells. The use of the findings of this work in drug design may be expected to yield good results.

Cite this paper
Ani, O. , Ani, A. and Chukwuneke, J. (2015) Spectrophotometric Data in Human Immunodeficiency Virus (HIV)-Antiretroviral Drug Coated Blood Interactions. Journal of Biosciences and Medicines, 3, 44-52. doi: 10.4236/jbm.2015.38005.
References
[1]   Achebe, C.H. (2010) Human Immunodefficiency Virus (HIV)-Blood Interactions: Surface Thermodynamics Approach. Ph.D. Dissertation, Nnamdi Azikiwe University, Awka.

[2]   United States Department of Health and Human Services (2004) A Guide to Primary Care for People with HIV/AIDS. 2004 Edition.

[3]   Achebe, C.H. and Omenyi, S.N. (2013) The Effects of Human Immunodeficiency Virus (HIV) Infections on the Absorbance Characteristics of Different Blood Components. International Journal of Engineering and Science Invention, 2, 53-61. www.ijesi.org

[4]   Ani, O.I. (2015) Surface Energetics Study of the Interactions between HIV and Blood Cells Treated with Antiretroviral Drugs. Ph.D. Dissertation, Nnamdi Azikiwe University, Awka.

[5]   Achebe, C.H. and Omenyi, S.N. (2013) The Application of Negative Hamaker Concept to the Human Immunodeficiency Virus (HIV)-Blood Interactions Mechanism. In: Yang, G.-C., Ao, S.-L. and Gelman, L., Eds., Transactions on Engineering Technologies—Special Volume of the World Congress on Engineering 2013, Springer, Berlin, 281-293.
http://dx.doi.org/10.1007/978-94-017-8832-8_21

[6]   Ozoihu, E.M. (2014) Human Immunodefficiency Virus (HIV)-Blood Interactions: Contact Angle Approach. Ph.D. Dissertation, Nnamdi Azikiwe University, Awka.

 
 
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