Determination of the Compound Biological Effectiveness (CBE) Factors Based on the ISHIYAMA-IMAHORI Deterministic Parsing Model with the Dynamic PET Technique

Shintaro  Ishiyama; Yoshio  Imahori; Jun  Itami; Hanna  Koivunoro

doi:10.4236/jct.2015.68083

Shintaro Ishiyama¹, Yoshio Imahori², Jun Itami³, Hanna Koivunoro⁴

Abstract: Purpose: In defining the biological effects of the 10B(n, α)7Li neutron capture reaction, we have proposed a deterministic parsing model (ISHIYAMA-IMAHORI model) to determine the Compound Biological Effectiveness (CBE) factor in Borono-Phenyl-Alanine (BPA)-mediated Boron Neutron Capture Therapy (BNCT). In present paper, we demonstrate a specific method of how the application of the case of application to actual patient data, which is founded on this model for tissues and tumor. Method: To determine the CBE factor, we derived the following new calculation formula founded on the deterministic parsing model with three constants, CBE0, F, n and the eigen value Nth/Nmax. (1), where, Nth and Nmax are the threshold value of boron concentration of N and saturation boron density and CBE0, F and n are given as 0.5, 8 and 3, respectively. In order to determine Nth and Nmax in the formula, sigmoid logistic function was employed for 10B concentration data, Db(t) obtained by dynamic PET technique. (2), where, A, a and t0 are constants. Results and Conclusion: From the application of sigmoid function to dynamic PET data, it is concluded that the Nth and Nmax for tissue and tumor are identified with the parameter constants in the sigmoid function in Equation (2) as: (3). And the calculated CBE factor values obtained from Equation (1), with Nth/Nmax.

Keywords: Boron Neutron Capture Therapy, Compound Biological Effectiveness, Borono-Phenyl-Alanine, Tumor, 10B(n, α)7Li, Sigmoid Function

Cite this paper: Ishiyama, S. , Imahori, Y. , Itami, J. and Koivunoro, H. (2015) Determination of the Compound Biological Effectiveness (CBE) Factors Based on the ISHIYAMA-IMAHORI Deterministic Parsing Model with the Dynamic PET Technique. Journal of Cancer Therapy, 6, 759-766. doi: 10.4236/jct.2015.68083.

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