OJOph  Vol.5 No.3 , August 2015
Treatment of Conjunctival Malignant Melanoma with Topical Interferon Alpha-2a
ABSTRACT
Conjunctival malignant melanoma (CMM) is a potentially lethal neoplasm with a high rate of recurrence. The modality of treatment includes a wide surgical excision, cryotherapy, topical mitomycin C and Interferon alpha 2b (INF α 2b). The aim of the study is to present the treatment of a case with CMM using topical Interferon alpha 2a. We present a 38-year-old female with diffuse bulbar dark pigmentation of the conjunctiva that arises from previously primary acquired melanosis (PAM). Biopsy resulted positive for CMM and further investigations were negative for any metastasis. Treatment with topical interferon alpha 2a was started immediately and after three months melanoma disappeared. One year after follow-up there was no sign of recurrence in regional lymph nodes or distant metastasis.

Cite this paper
Salihu, N. , Pustina, B. and Drnovšek-Olup, B. (2015) Treatment of Conjunctival Malignant Melanoma with Topical Interferon Alpha-2a. Open Journal of Ophthalmology, 5, 91-93. doi: 10.4236/ojoph.2015.53014.
References
[1]   Misra, S., Misra, N., Gogri, P., Reddy, V. and Bhandari, A. (2013) A Case of Conjunctival Malignant Melanoma with Local Recurence. Australasian Medical Journal, 6, 344-347.
http://dx.doi.org/10.4066/AMJ.2013.1728

[2]   Shields, C.L., Kels, J.G. and Shields, J.A. (2015) Melanoma of the Eye: Revealing Hidden Secrets, One at a Time. Clinics in Dermatology, 33, 183-196.
http://dx.doi.org/10.1016/j.clindermatol.2014.10.010

[3]   Kanski, J.J. and Bowling, B. (2011) Clinical Ophthalmology: A Systematic Approach. 7th Edition, Elsevier Saunders, Edinburgh, 482-483.

[4]   Finger, P.T., Sedeek, R.W. and Chin K.J. (2008) Topical Interferon Alfa in the Treatment of Conjunctival Melanoma and Primary Acquired Melanosis Complex. American Journal of Ophthalmology, 145, 124-129.
http://dx.doi.org/10.1016/j.ajo.2007.08.027

[5]   Ningrum, R.A. (2014) Human Interferon Alpha-2b: A Therapeutic Protein for Cancer Treatment. Scientifica, 2014, Article ID: 970315, 8 p.

 
 
Top